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This study investigates the influence of polypropylene fibres (PF) on concrete performance across a finely resolved dosage spectrum (0.0–2.0% by cement mass, in 0.1% increments) using 2,100 laboratory specimens. The experimental programme evaluated compressive strength, tensile strength (flexural and splitting), modulus of elasticity, and water penetration depth. Predictive modelling was conducted

The standard assessment of mental health typically involves clinical interviews conducted by highly trained clinicians. While effective, this approach faces substantial limitations, including high costs, high clinician workload, variability in expertise, and a lack of standardization. Recent progress in large language models (LLMs) offer a promising avenue to address these limitations by simulatin

Developing a robust decision analysis framework for selecting appropriate building envelope assemblies is essential to ensure moisture safety, energy efficiency, and sustainability. Recently, Bayat Pour et al. introduced the inutility decision analysis (IDA) method, which integrates moisture safety criteria with sustainability considerations, including economic and environmental aspects. This stud

OBJECTIVE: To evaluate if opioid-free anaesthesia (OFA), is non-inferior to standard of care (SOC), in patients at low risk for acute postoperative pain (APOP).DESIGN: Patient- and assessor-blinded, non-inferiority, randomised, controlled trial.SETTING: Single centre between March 2022 to February 2024.PATIENTS: 154 adult patients, ASA I - II, planned for elective laparoscopic surgery and risk-cla

Thirty years on, gender mainstreaming is still a dominant strategy for working with gender equality, even though its effectiveness is debated. This is also the case in Sweden. This study focuses on how organisations in public administration, particularly municipalities and regions, are introduced to and approach gender mainstreaming. It aims to contribute with in-depth knowledge of how organisatioThirty years on, gender mainstreaming is still a dominant strategy for working with gender equality, even though its effectiveness is debated. This is also the case in Sweden. This study focuses on how organizations in public administration, particularly municipalities and regions, are introduced to and approach gender mainstreaming. It aims to contribute with in-depth knowledge of how organizatio

Understanding vegetation sensitivity to hydroclimate factors, especially how carbon and water cycles respond to climate change, is crucial for assessing ecosystem vulnerability. However, the seasonal sensitivity of carbon and water fluxes to temperature, radiation, soil water content, and vapor pressure deficit across diverse biomes and climates remains unclear. Here, we use 196 eddy covariance ob

Vegetation demographic models (VDMs) are advanced tools for simulating forest responses to climate and land-use changes, and are essential for projecting carbon cycling and large-scale forest management strategies. Despite their increasing incorporation into Earth System Models, VDMs differ in their demographic assumptions, with no prior quantitative comparison of their performance. We benchmarked

Disturbances play a key role in forest dynamics globally, with various effects on productivity. Tree diversity is expected to attenuate the negative impact of disturbance on forest productivity, but its overall effect has been little explored and might depend on the functional composition. Here, we analysed whether forest productivity responses to disturbances were modulated by structural and func

Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a promising new synthetic lethal target for developing drugs to treat cancers with MSI. Given the uncertainty of how effective inhibitors of WRN activity will prov

Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397–1415) reveal HROB as a new player in HR required for recruitment of the MCM8–9 complex, which is paralogous to the MCM2–7 replicative helicase. HR

DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during cell division. However, how chromatin assembly and DNA replication are integrated remains unclear. We examined the contribution of the Tousled-like kinases 1 and 2 (TLK1/TLK2) to chromatin assembly and maintenance of replication fork integrity. We show that TLK activ

Transboundary crises often create a problem of fit, where existing institutional structures are inadequate to meet the demands of the situation, requiring strategic adaptations. This study examines how Italy, Sweden, and Norway, in different ways, addressed national-level leadership needs of decision-making, coordination, and information flow during the early onset of the COVID-19 pandemic, not on

While a naive algorithm for multiplying two 2 × 2 matrices requires eight multiplications and four additions, Strassen showed how to compute the same matrix product using seven multiplications and 18 additions. Winograd reduced the number of additions to 15, which was assumed to be optimal. However, by introducing a change of basis, Karstadt and Schwartz showed how to lower the number of additions

Histone chaperones control nucleosome density and chromatin structure. In yeast, the H3-H4 chaperone Spt2 controls histone deposition at active genes but its roles in metazoan chromatin structure and organismal physiology are not known. Here we identify the Caenorhabditis elegans ortholog of SPT2 (CeSPT-2) and show that its ability to bind histones H3-H4 is important for germline development and t