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INTRODUCTION: Plasma phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and amyloid beta ratio (Aβ42/40) may have diagnostic and prognostic value in Alzheimer's disease (AD). Here we assess which markers can best identify AD from controls and other non-AD dementias in a large international multi-center study. METHODS: Plasma samples (n = 1298) w
Although leuprorelin acetate, a luteinizing hormone-releasing hormone agonist, has been approved based on short-term clinical trials conducted in Japan, its long-term efficacy on physical function remains unclear. We aimed to evaluate the long-term therapeutic efficacy of leuprorelin acetate using real-world clinical data through a self-controlled trend-shift analysis. The analysis included 91 gen
A hybrid assistive limb (HAL) can improve the motor performance of patients with various neurodegenerative diseases, but the efficacy of home-based rehabilitation using HAL for spinocerebellar ataxias (SCA) has yet to be elucidated. To evaluate the efficacy and safety of home-based telerehabilitation with lumbar type HAL in patients with SCA. In this non-randomized open-label single center trial,
Chemical defences, such as the monoterpenes of conifer oleoresin, frequently occur as complex blends of many components, but the selective pressures that maintain these mixtures are not yet known. Several theories attempt to explain the existence of chemical defence mixtures in plants. However, due to limited empirical evidence, it is unclear which theories might best apply. Here, we tested the va
BACKGROUND: Artificial intelligence may improve diagnostic yield and accuracy in syncope.OBJECTIVES: The purpose of this study was to compare Generative Pretrained Transformer 4-Omni (GPT-4o) with medical professionals (MPs) in establishing syncope diagnoses and recommending interventions based on general practitioner's referral letters to a syncope-unit.METHODS: This three-phase study evaluated 5
The Swedish Constitution consists of four constitutional acts, and one of them is the Instrument of Government (Regeringsformen). It was enacted in 1974 and entered into force 1st January 1975. This year, it has functioned as the most important constitutional act in Sweden for 50 years. Its name, the Instrument of Government, was used for the first time in 1634, when a constitutional act was issue
Erik Olin Wright (1947–2019) var en amerikansk samhällsforskare, disputerad i sociologi och engagerad i marxistiska frågor om ojämlikhet, förtryck och möjligheterna till frigörelse genom samhällsomvandling. Hans svar var långt ifrån alltid renläriga, och att Wright inte såg något egenvärde i att noga hålla sig inom en viss tanketradition är kännetecknande för hans akademiska arbete. Själv beskrev
BackgroundLarge-scale genomic rearrangements in cancer cells can lead to the creation of fusion genes which alter the expression or function of the partner genes. Some fusion genes act as tumour drivers and the use of kinase inhibitors in patients with specific fusions have led to breakthroughs in cancer therapy. The large clinical and scientific interest in fusions has led to the development of s
Coastal eutrophication results from increased riverine loads of inorganic nutrients, including phosphorus (P), which may co-occur with increased dissolved organic carbon (DOC) loading. These DOC molecules are often pigmented, causing water darkening, but they also contain dissolved organic P (DOP), which could exacerbate eutrophication. However, it is unclear how the bioavailable DOP (BDOP) pool r
Introduction: Attention-deficit/hyperactivity disorder (ADHD) is overrepresented among children and adults with obesity, but knowledge about how ADHD may affect outcomes following metabolic and bariatric surgery (MBS) is limited. The aim of this study was to examine mental health and weight outcomes after undergoing MBS during adolescence in individuals with and without ADHD. Methods: In a multice
Congenital vascular malformations, affecting 0.5% of the population, often occur in the head and neck, complicating treatment due to the critical functions in these regions. Our previous research identified distinct developmental origins for blood and lymphatic vessels in these areas, tracing them to the cardiopharyngeal mesoderm (CPM), which contributes to the development of the head, neck, and c
Greta Thunberg has gained increasing attention in global climate politics, in particular since the Fridays for Future movement she initiated in 2018. Attention has also come with criticism, denouncing her for being part of a transnational youth climate elite made up of privileged youth. However, does such an elite really exist, and what does it mean for global climate politics? This article invest
One purpose of academic development work is to ensure university teachers use evidence-based teaching approaches. Academic developers often teach colleagues about the latest teaching approaches and model these to enable teachers to see the use of evidence-based methods in practice, aiming to inspire teachers to adopt similar approaches. Active learning and co-creation are approaches that have been
From the introduction: "If you are a teacher in higher education, you are probably focused on student learning and committed to improving your teaching. Here, we introduce you to the Scholarship of Teaching and Learning (SoTL), the 'inquiry into teaching and learning for the purposes of improving [it] in context and contributing to what we know about [it], in support of the broader aims of higher
