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Alzheimer’s Disease (AD) is a devastating neurodegenerative disease associated with massive neuronal cell death during its pathology. The involvement of the amyloid β 42 (Aβ42) peptideand its role in neurotoxicity is now well established. It is known that the production of oligomers during the aggregation of Aβ42 into highly ordered fibrils is responsible for neuronal cell death. However, the effo
Objective: Fenestrated endovascular aortic aneurysm repair (FEVAR) for juxtarenal aortic aneurysm (jAAA) disease is safe and effective with good short- and mid-term outcomes. The durability issues have mainly focused on the proximal and distal seal and target vessel (TV) instability, and long-term data are scarce. In previous studies, we have reported the short-term outcomes after FEVAR and compar
Purpose: Early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) differ in neuropathological burden and type of cognitive deficits. Assessing tau pathology and relative cerebral blood flow (rCBF) measured with [18F]flortaucipir PET in relation to cognition may help explain these differences between EOAD and LOAD. Methods: Seventy-nine amyloid-positive individuals with a cl
rapidly and on a large scale, judging from the very short introduction phase for late Slavic pottery and the absence of hybrid forms between this tradition and the local Scandinavian ware. Late Slavic ware became a Scanian cultural trait after only one generation; this tradition is today called “Baltic ware”, as it was produced outside the Slavic area by an increasing number of local potters. AfteThe existence of slavery in Viking-Age and high medieval Scandinavia is accepted as a fact. Law codes, literary sources and some few burials vouch for that. It is, however, more complicated to ascertain regional differences in the use of slaves, their ethnic identities and geographical distribution, as well as changes in the intensity of their exploitation over time. A new source, household potter
Nature-based Solutions (NbS) are currently promoted as a panacea for improving human-nature relations. Yet the way of amplifying and mainstreaming NbS beyond scientific demonstrator projects into policy contexts is still bearing shortcomings, in particular in the uncertain futures of a post-COVID-19 world. Successful NbS amplification may be achieved by (1) using multi-scalar action to balance dif
Why, in the midst of the global Coronavirus pandemic, do so many people seem resistant to the recommendations of established medical experts? In this chapter, I explore possible structural causes of this resistance in the U.S. context. I argue that in the “post-truth” era, attempts to encourage people to wear face masks and get vaccinated confront challenges pertaining to how scientific knowledge
This dissertation analyzes and evaluates several major productions by Danish philosopher and theologian Søren Kierkegaard (1813–1855). It focuses on three works Kierkegaard authored under pseudonyms – Either / Or (1843), Fear and Trembling (1843), and Philosophical Fragments (1844) – and the non-pseudonymously authored Works of Love (1847). The dissertation argues that for Kierkegaard, Christian f
In this study, we demonstrate an acoustofluidic device that enables single-file focusing of submicron particles and bacteria using a two-dimensional (2D) acoustic standing wave. The device consists of a 100 μm × 100 μm square channel that supports 2D particle focusing in the channel center at an actuation frequency of 7.39 MHz. This higher actuation frequency compared with conventional bulk acoust
The clinical utility of microfluidic techniques is often hampered by an unsatisfying sample throughput. Here, the effect of inertial forces on acoustofluidic particle sorting at high sample throughputs is investigated experimentally and theoretically. Polystyrene particles are acoustically prefocused to obtain precise trajectories. At increased flow rates it is observed that the particle stream is
While the association between economic freedom and long-term economic growth has been well documented, the parallel research literature on the distributional consequences of economic freedom is full of conflicting findings. In this paper, we take a step toward reconciling these two bodies of literature by exploring the within-quintile growth consequences of changes in three separate elements of ec
In this 20-year anniversary editorial of ephemera, we discuss independent publishing by situating it in a changing academic landscape – one scarred by despair but also leavened by hope. Twenty years ago, the goal of publishing an open access peer-reviewed journal was a radical political gesture in itself. Today, the model of open access publishing has been appropriated, hollowed out, and commodifi
This issue celebrates 20 years of ephemera. We, the editorial collective, feel this anniversary provides the opportunity to debate the pasts, presents and futures of critical publishing. Today, most academic journals are owned by commercial publishing houses and organized according to journal rankings and impact factors. Yet ephemera remains stubbornly independent of these global capitalist forces
The plastic industry is dependent on fossil fuels in various ways that result in strong “carbon lock-in” throughout the value chain and large and growing CO2 emissions. The industry must decarbonize to reach global net-zero pledges. Although a few initiatives have been launched, they primarily focus on plastic waste. Current research has investigated mitigation potential on different parts of the
To the best of our knowledge, "sweet mini bell" peppers have not been extensively investigated. In this study, we evaluated the bioaccessible phenolic compounds released during intestinal digestion and identified and quantified the microbial metabolites derived from phenolic compounds bioconversion during the in vitro colonic fermentation. A total of 66 phenolic compounds were determined. The resu
Seventy five percent of the world's food crops benefit from insect pollination. Hence, there has been increased interest in how global change drivers impact this critical ecosystem service. Because standardized data on crop pollination are rarely available, we are limited in our capacity to understand the variation in pollination benefits to crop yield, as well as to anticipate changes in this ser
