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Breast and prostate cancer preferentially metastasize in the skeleton, inducinglocally increased bone resorption by osteoclasts. Bisphosphonates (BPs), potent inhibitors of osteoclasts and bone resorption, are able to reduce metastatic bone lesions, but the metastasis-related cellular target molecules for BPs have not yet been identified. In osteoclasts, nitrogen-containing BPs inhibit the functio
In the Swedish National Care Programme for Hodgkin's lymphoma (HL) a less intensive chemotherapy regimen with individualized dosing (LVPP/OEPA) was introduced in 1989. In total, 139 patients, 77 between 1985 and 1988 and 62 between 1989 and 1992, were studied. Mean ages were 72 and 71 years, respectively. One hundred and nineteen patients were treated with curative intention, 63 (82%) between 1985
ABSTRACT. Differences in labour force participation and unemployment rates between indigenous populations and immigrants are common throughout Europe. But the gap seems to be particularly wide in Sweden. Based on studies of work places that traditionally employed large numbers of immigrants, but where they are now declining, it is argued that a driving force behind this process of exclusion is to
When plant tissue is wounded a number of protective processes start. We have made a study by isothermal calorimetry of the heat production response of root and tuber tissue to wounding. Samples with different surface to volume ratios were prepared from carrots, potatoes and swedes (rutabaga) and the thermal power was measured in closed glass ampoules in a TAM Air isothermal calorimeter. The evalua
The increase in Ca(2+)-activated force caused by polyamines in beta-escin-permeabilized guinda pig ileum is shown to be associated with increased myosin 20-kDa light chain (LC20) phosphorylation and shortening velocity. Myosin LC20 dephosphorylation with arrested kinase activity was slower in the presence of 1 mM spermine. Smooth muscle phosphatases (SMP-I, -II, -III, and -IV) isolated from turkey
The theme of this thesis is to study discretizations of nonlinear dissipative evolution equations, which arise in e.g. advection-diffusion-reaction processes. The convergence analysis is conducted by first considering an abstract time discretization of the problem, which enables a decoupling of the time and spatial approximations, and secondly by introducing the spatial discretization as an evolut
Chipped tobacco stalks were subjected to steam pretreatment at 205 degreesC for either 5 or 10 min before enzymatic hydrolysis. Glucose (15.4 - 17.1 g/l) and xylose (4.5-5.0 g/l) were the most abundant monosaccharides in the hydrolysates. Mannose, galactose and arabinose were also detected. The hydrolysate produced by pretreatment for 10 min contained higher levels of all sugars than the 5 min-pre
Surgical procedures in hemophiliacs is a demanding challenge for the surgeon and hematologist. This report deals with a successful laparoscopic cholecystectomy in a young patient with hemophilia B. Despite a prolonged operation time, because of a partially intrahepatic gallbladder, no bleeding complications were registered and the patient recovered well. Laparoscopic cholecystectomy seems to be th
A gas chromatographic-ion trap tandem mass spectrometric method was developed for the quantification of muramic acid, a marker of bacterial peptidoglycan, in environmental and clinical specimens. Samples (bacteria, house dust and urine) were heated in methanolic hydrochloric acid overnight and extracted with hexane for removal of hydrophobic compounds. The aqueous phase was evaporated and heated i
Measurement of bone mineral concentration (BMC) can be done by several modalities. Quantitative computed tomography (QCT) can be used for measurements at different sites and with different types of bone (trabecular-cortical). This study presents a modified method reducing the influence of fat. Determination of BMC was made from measurements with single-energy computed tomography (CT) of the mean H
Context: Insulin-stimulated glucose uptake in skeletal muscle is mediated through translocation of the insulin-sensitive glucose transporter 4 ( GLUT4)-containing vesicles to the plasma membrane. Thus, skeletal muscle GLUT4 content plays an important role in whole-body insulin sensitivity. Objectives: The objectives of this study were 1) to examine the relative impact of genetic vs. environmental
We review the present status of the hadronic light-by-light contribution to muon g - 2 and critically compare recent calculations.
In this paper, the results of different multiple window spectrum analysis methods are compared in the estimation of heart rate variability (HRV) power spectra, in the high frequency band (HF), around 0.25 Hz, related to respiratory sinus arrhythmia (RSA). The evaluation is performed by simulating different spectrum shapes and peak frequency locations and calculating the mean squared error of a fre
