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Objectives: Sjögren's disease (SjD) and systemic lupus erythematosus (SLE) share genetic risk at the DDX6-CXCR5 locus (11q23.3). Identifying and functionally characterising shared SNPs spanning this locus can provide new insights into common genetic mechanisms of autoimmunity. Methods: Transdisease meta-analyses, fine-mapping, and bioinformatic analyses prioritised shared likely functional single
The years 2023 and 2024 were characterized by unprecedented warming across the globe, underscoring the urgency of climate action. Robust science advice for decision makers on subjects as complex as climate change requires deep cross- and interdisciplinary understanding. However, navigating the ever-expanding and diverse peer-reviewed literature on climate change is enormously challenging for indiv
This paper presents a measurement of jet-track correlations in photon-jet events, using 1.72 (Formula presented) of (Formula presented) data at (Formula presented) recorded with the ATLAS detector at the LHC. Events with energetic photon-jet pairs are selected, where the photon and jet are approximately back-to-back in azimuth. The angular correlation between jets and charged-particle tracks with
Importance: While clinical disease stages remained largely unchanged in the 2024 update of the Alzheimer disease (AD) criteria, tau-positron emission tomography (PET) was introduced as a core biomarker and its spatial extent was incorporated into the revised biological stages of the disease. It is important to consider both the clinical and the biological stages and understand their discrepancies.
During the 2015–2018 data-taking period, the Large Hadron Collider delivered proton-proton bunch crossings at a centre-of-mass energy of 13 TeV to the ATLAS experiment at a rate of roughly 30 MHz, where each bunch crossing contained an average of 34 independent inelastic proton-proton collisions. The ATLAS trigger system selected roughly 1 kHz of these bunch crossings to be recorded to disk. Offli
Recovery Colleges (RCs) are learning-based mental health recovery communities, located globally. However, evidence on RC effectiveness outside Western, educated, industrialised, rich, and democratic (WEIRD) countries is limited. This study aimed to evaluate associations between cultural characteristics and RC fidelity, to understand how culture impacts RC operation. Service managers from 169 RCs s
Congenital anomalies of the kidneys and urinary tract (CAKUT) are developmental disorders that commonly cause pediatric chronic kidney disease and mortality. We examine here rare coding variants in 248 CAKUT trios and 1742 singleton CAKUT cases and compare them to 22,258 controls. Diagnostic and candidate diagnostic variants are detected in 14.1% of cases. We find a significant enrichment of rare
We show exponential lower bounds on resolution proof length for pigeonhole principle (PHP) formulas and perfect matching formulas over highly unbalanced, sparse expander graphs, thus answering the challenge to establish strong lower bounds in the regime between balanced constant-degree expanders as in [Ben-Sasson and Wigderson’01] and highly unbalanced, dense graphs as in [Raz’04] and [Razborov’03
Objective: Establishing the incidence and types of complications following surgical intervention for ARM, primarily after reconstruction. Patient- and treatment-related risk factors were also determined. Background: Postoperative complications of ARM surgery vary widely, with data predominantly derived from single-center retrospective studies with limited number of patients. Whether factors such a
Det övergripande syftet med denna studie är att finna strategier för att skapa ett friskare arbetsliv långt upp i åren och för att se äldre medarbetare som en viktig resurs vilket organisationen bör värna om och förvalta. I denna rapport studeras enkätsvaren från cirka 2 000 medarbetare 55 år eller äldre inom hälso- och sjukvården. De svarande kom från yrkesgrupperna läkare, sjuksköterska, sjukgym
A search for decays of the Higgs boson into a Z boson and a light resonance, with a mass of 0.5–3.5 GeV, is performed using the full 140 fb−1 dataset of 13 TeV proton–proton collisions recorded by the ATLAS detector during LHC Run 2. Leptonic decays of the Z boson and hadronic decays of the light resonance are considered. The resonance can be interpreted as a J/ψ or ηc meson, an axion-like particl
The distribution of angular correlations between prompt charm hadrons and primary charged particles in pp collisions is sensitive to the charm-quark hadronisation process. In this letter, charm-baryon correlations are measured for the first time by studying the azimuthal-angle difference between charged particles and prompt Λc+ baryons produced in pp collisions at a centre-of-mass energy of s=13 T
In this letter, we present the first measurement of direct photons at the transverse momentum of 1
Measurements of jet substructure are key to probing the energy frontier at colliders, and many of them use track-based observables which take advantage of the angular precision of tracking detectors. Theoretical calculations of track-based observables require ‘track functions’, which characterize the transverse momentum fraction rq carried by charged hadrons from a fragmenting quark or gluon. This
Micropollutant removal is a key component of the revised Urban Wastewater Treatment Directive (UWWTD) and can be achieved with ozonation. During ozonation, the composition of the wastewater matrix and the targeted treatment level for individual micropollutants or groups of such compounds affect ozone consumption. In this work, it was hypothesized that nitrite scavenging, the point of dosing (befor
Streets are emerging as vibrant platforms of public life. While mobility continues to be the dominant function of these spaces, streets are being reconfigured by various stakeholders to promote multifunctional benefits, including socialisation and inclusion, play and rest, political action, economic opportunities, biodiversity, and cultural expression. This thematic issue includes a wide range of
This narrative Review explores the role of hyperinsulinaemia as a potential independent contributor to obesity and cardiometabolic diseases. We argue that scientific discussions about the role of hyperinsulinaemia as a causal factor in these conditions have not sufficiently distinguished between postprandial insulin excursions and chronically elevated basal levels of insulin. We summarize findings
Despite the central role supervision plays inshaping students’ academic and professional development,Swedish regulations offer limited guidance on MSc thesissupervision by PhD students. This study conducted aqualitative research design and thematic analysis to explore theexperiences and challenges of PhD students supervising MSctheses and master’s students supervised by PhD candidates atthe Facult
This article investigates social media users’ attitudes towards Swedish dialects. It presents an analysis of 778 comments from Facebook and TikTok reacting to five short videos featuring a girl speaking a dialect typical of Värmland on Swedish national television. The analysis reveals that most comments express positive evaluations, describing the dialect as underbar ‘wonderful’, härlig ‘lovely’ a
