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This report compiles the findings concerning the “Initial version of CBMD framework and co-creation process approach”, hereafter be referred to as “circular product-service system innovation support method” (cPSS method). The report has been compiled from an extensive review of the literature from a variety of inter-related academic research fields, including business model theory, product service
Hard-to-reach (HTR) energy users encompass individuals who are physically difficult to reach, underserved, or challenging to engage and motivate in demand-side energy programmes. Given a mix of societal challenges (e.g. inequity, energy poverty, decarbonisation, the COVID-19 pandemic), HTR energy users are receiving increasing attention. However, there is a lack of knowledge on the performance of
The European Green Deal states that greenhouse gas (GHG) emissions should be reduced by at least 50% by 2030, and that there should be no net GHG emissions by 2050. The energy sector is a key in this transformation, and energy communities can as accelerators of transitionsKey findings:•Future scenarios outline a decentralized energy system in which smaller generation units have become more economi
Circular economy in the building industry has gained much attention in recent years, yet thus far, little research has been conducted on the topic of intensified building use, despite its great potential in terms of emission reduction. One way to intensify building use can be by sharing spaces among different users at different times. This study explores how the cities of Amsterdam and Malmö enabl
The ongoing environmental crisis and the growing socio-economic disparities between different population groups are among the most significant challenges facing humanity. These problems are rooted in unsustainable consumption patterns, particularly in the more affluent societies worldwide. We, therefore, need to change existing consumption patterns, which is a considerable challenge. A sustainable
BACKGROUND: Current models of levodopa (L-dopa)-induced dyskinesia (LID) are obtained by treating dopamine-depleted animals with L-dopa. However, patients with LID receive combination therapies that often include dopamine agonists.OBJECTIVE: Using 6-hydroxydopamine-lesioned rats as a model, we aimed to establish whether an adjunct treatment with the D2/3 agonist ropinirole impacts on patterns of L
Dopamine replacement therapy for Parkinson's disease is achieved using L-DOPA or dopamine D2/3 agonists, such as ropinirole. Here, we compare the effects of L-DOPA and ropinirole, alone or in combination, on patterns of glial and microvascular reactivity in the striatum. Rats with unilateral 6-hydroxydopamine lesions were treated with therapeutic-like doses of L-DOPA (6 mg/kg), an equipotent L-DOP
(1) Background: Obstructive sleep apnea (OSA) is common in patients with coronary artery disease (CAD), in which a rupture of atherosclerotic plaques and oxidative stress play a role in the initiation and progression of the disorder. Circulating levels of myeloperoxidase (MPO), as an oxidative stress marker, as well as matrix metalloproteinase-9 (MMP-9), as a destabilizer of plaques, are known to
The regional development studies community increasingly focuses on the significance of agency when investigating why some regions or cities develop better or worse than others. Undoubtedly, this line of research increases our understanding of the relations and interplay between human actions and socially produced structures. The articles in this special issue follow this research agenda by focusin
A growing body of research suggests that the global conception of climate change is increasingly taking a justice-focus. However, the justice-framings of different actors in the UNFCCC process and their evolution have not yet been examined. We conduct a critical discourse analysis of climate justice claims of state and non-state actors in COP15, COP19, COP21 and COP24 which are key moments for cli
In flowering plants that produce concealed rewards, pollinator foraging preferences may select for floral advertisement traits that are correlated with rewards. To date, studies have not focused on the potential for honest signals to vary across populations, which could occur due to differences in pollinator communities or plant mating system. We tested for variation in honest signals across and w
Online engagement with criminal cases is often interpreted in either punitive or crowdsourcing terms, but interactionist and ethnomethodological analyses can disclose other and more fundamental aspects. This chapter looks closely at a particular practice among posters on the Swedish platform Flashback: that of summing up the discussion ‘so far’. To sum up is a delicate and vulnerable act of rhetorOnline engagement with criminal cases is often interpreted in either punitive or crowdsourcing terms, but interactionist and ethnomethodological analyses can disclose other and more fundamental aspects. This chapter looks closely at a particular practice among posters on the Swedish platform Flashback: that of summing up the discussion ‘so far’. To sum up is a delicate and vulnerable act of rhetor
Introduction: Coeliac disease is a lifelong immune-mediated enteropathy manifested as gluten intolerance in individuals carrying specific human leukocyte antigen (HLA) molecules. Other factors than genetics and gluten intake, however, may play a role in triggering the disease. The gut internal environment is thought to be one of these potential contributing factors, and it can be influenced throug
FlexPES is a soft X-ray beamline on the 1.5 GeV storage ring at MAX IV Laboratory, Sweden, providing horizontally polarized radiation in the 40-1500 eV photon energy range and specializing in high-resolution photoelectron spectroscopy, fast X-ray absorption spectroscopy and electron-ion/ion-ion coincidence techniques. The beamline is split into two branches currently serving three endstations, wit
SARS-CoV-2 and its ever-emerging variants are spread from host-to-host via expelled respiratory aerosols and saliva droplets. Knowing the number of virions which are exhaled by a person requires precise measurements of the size, count, velocity and trajectory of the virus-laden particles that are ejected directly from the mouth. These measurements are achieved in 3D, at 15,000 images/s, and are ap
Objective: This multicenter international study aimed to describe outcomes of fenestrated-branched endovascular aortic repairs (FB-EVAR) in a cohort of patients treated for chronic post-dissection thoracoabdominal aortic aneurysms (PD-TAAAs). Methods: We reviewed the clinical data of all consecutive patients treated by FB-EVAR for repair of extent I to III PD-TAAAs in 16 centers from the United St
The European Respiratory Society (ERS) celebrated the return of an in-person meeting in Barcelona, Spain, after 2 years of virtual congresses. The ERS Congress 2022 programme was replete with symposia, skills workshops and abstract presentations from all 14 assemblies, encompassing over 3000 abstracts presented in the form of thematic poster discussion and oral presentations. In this article, high
The COVID-19 pandemic has illuminated the lack of knowledge regarding the airborne transmission pathway of disease. The pathway consists of pathogens contained in small particles ejected when speaking and coughing. A crucial characteristic of these particles is their size that is connected to the their suspension longevity in the air as well as the location of generation and deposition within a su
