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Importance: General practitioners (GPs) sometimes initiate a treatment despite not expecting it to improve patients' symptoms by any physiological mechanism. These essentially placebo treatments are ethically controversial, and their frequency is unclear. They involve risks for patients, but to estimate these, more data are needed. Objective: To develop a more precise overview of the rate at which

A majority of all infectious diseases manifest some climate-sensitivity. However, many of those sensitivities are not well understood as meteorological drivers of infectious diseases co-occur with other drivers exhibiting complex non-linear influences and feedback. This makes it hard to dissect their individual contributions. Here we apply a novel deep learning Explainable AI (XAI) compartment mod

It is a continued open question how there can be an azimuthal anisotropy of high p⊥ particles quantified by a sizable v2 in p+Pb collisions when, at the same time, the nuclear modification factor RAA is consistent with unity. We address this puzzle within the framework of the jet quenching model Jewel. In the absence of reliable medium models for small collision systems we use the number of scatte

Group exhibition.With beyond now. Editions, the Kestner Gesellschaft reflects on its exhibition history and the connection between artistic production and institutional work. This special exhibition includes both current and rediscovered limited-edition works, combining them with a series of related exhibition posters. A visual timeline traces the historical context of the works, their thematic co

INTRODUCTION: Social prescribing (SP) is an innovative model that connects individuals to non-clinical community resources. However, its uptake and evaluation have been hindered by inconsistent role definitions for key stakeholders. Although recent studies have refined SP definitions, outside the UK, the responsibilities, educational backgrounds and training requirements of social prescribing link

Highlights: What are the main findings? Health for adolescents with depression was described in terms of managing everyday life, building confidence and trust, experiencing joy in life, and supporting well-being. These aspects reflect how health can be understood through daily routines, relationships, emotional experiences, and lifestyle habits. What is the implication of the main finding? The fin

Advances in quantum computing pose a fundamental threat to classical public-key cryptosystems, including RSA and elliptic-curve cryptography (ECC), which form the foundation for authentication and key exchange in the Transport Layer Security (TLS) protocol. In response to these emerging threats, Korea launched the KpqC (Korea Post-Quantum Cryptography) project in 2021 to design, evaluate, and stan

Background/Objectives: Sepsis is a life-threatening condition characterized by organ dysfunction due to a dysregulated host response to infection. Mitochondrial dysfunction is considered a key contributor to the pathogenesis of sepsis, but its molecular mechanisms remain unclear. Methods: In this study, we used a cecal ligation and puncture (CLP) model to induce sepsis in wild-type (WT) and cyclop

Proteins and peptides are vital biomolecules, and deuterated amino acids are increasingly applied in areas such as drug discovery, metabolic tracing, and neutron scattering studies. In this study, we performed deuteration on all 20 proteinogenic amino acids, including their side chains, and established efficient methods for 13 amino acids. Using a Pt/C-catalyzed hydrogen–deuterium exchange reactio

The Human Right to Science is about the “human right to benefit from progress in science and its applications,” also known more succinctly as the “right to science.” Although the right to science is one of the oldest internationally recognized human rights, it has suffered too long from neglect. International organizations and States pay little attention to it. There are only a few inadequate indi

In recent years, there has been a growing scholarly interest in the cultural and political significance of joyful, positive and nostalgic memories and forms of remembrance. Without downplaying the role of trauma and oppression in the mnemonic makeup of contemporary societies, memory scholars have increasingly pointed to the co-existence, or parallel existence, of brighter recollections of the past

Background: The long-term impact of asthma on mortality remains uncertain. This study aimed to assess mortality and its predictors over 26 years in asthmatic participants compared to those with or without other respiratory symptoms. Methods: This longitudinal cohort study included participants recruited from the general Swedish population, followed from 1990 to 2016. The younger (30–39 years, n =

Introduction: Prenatal exposure to inflammatory states has been suggested to influence offspring neurodevelopment. The aim was to investigate if offspring exposure to maternal Inflammatory bowel disorder (IBD), or specifically the IBD disorder Crohn's disease, during gestation is associated with neurodevelopmental or psychiatric disorders in childhood. Material and Methods: We conducted a populati

Epithelial tissue fusion requires coordinated molecular events at the ends of two epithelial structures. Regulatory mechanisms controlling these events remain largely elusive. In the Drosophila reproductive system (RS), this fusion unites the gonad and the genital disc-derived tissues, into a continuous tube. This study unveils the pivotal role of Hamlet (Ham), a Drosophila PR domain containin

Background: Large bone defects are challenging to manage clinically and usually require treatment with bone graft or bone graft substitute. This study evaluated the effect of romosozumab, a sclerostin antibody, in combination with demineralized bone matrix (DBM) on bone regeneration in a critical-size ulnar defect model in nonhuman primates. Methods: In cynomolgus monkeys (N = 22, male, 10–12 year

Group exhibitionAn exhibition about apocalyptic thinking, despair, hope, and consolation in the Middle Ages and today, featuring live work by Tino Sehgal in de Kapel and works by Marina Abramović, Francis Alÿs, Joseph Beuys, Michaël Borremans, Miriam Cahn, Lucas Cranach I, Thierry De Cordier, Albrecht Dürer, Marlene Dumas and many others in the galleries.

Group exhibitionThe hunt for intoxication is a human constant. What are we looking for in intoxication, especially if it is drug-based, and why do we knowingly accept the dangers? What promise does intoxication through cannabis offer? The hemp plant contains more than 150 active substances, of which the most common are THC (tetrahydrocannabinol) and CBD (cannabidiol). How do these affect the brain