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BackgroundIn the splice variant factor (F)V-Short, 702 residues are deleted from the B domain, resulting in exposure of an acid region (AR2; 1493-1537) that binds TFPIα. FV-Short and protein S serve as synergistic TFPIα cofactors in inhibition of FXa. In the preAR2 region, a hydrophobic patch PLVIVGL (1481-1487) is crucial for synergistic TFPIα-cofactor activity and assembly of FV-Short, TFPIα, anBackgroundIn the splice variant factor (F)V-Short, 702 residues are deleted from the B domain, resulting in exposure of an acid region (AR2; 1493-1537) that binds TFPIα. FV-Short and protein S serve as synergistic TFPIα cofactors in inhibition of FXa. In the preAR2 region, a hydrophobic patch PLVIVGL (1481-1487) is crucial for synergistic TFPIα-cofactor activity and assembly of FV-Short, TFPIα, an

The IFMIF-DONES Facility is a unique first-class scientific infrastructure whose construction is foreseen in Granada, Spain, in the coming years. Strong integration efforts are being made at the current project phase aiming at harmonizing the ongoing design of the different and complex Systems of the facility. The consolidation of the Diagnostics and Instrumentation, transversal across many of the

The European Spallation Source, currently under construction in Lund, Sweden, is a multidisciplinary international laboratory. Once completed to full specifications, it will operate the world’s most powerful pulsed neutron source. Supported by a 3 million Euro Research and Innovation Action within the EU Horizon 2020 program, a design study (HighNESS) has been completed to develop a second neutron

Recent experiments at the Brazilian Synchrotron Ligth Source (LNLS) Ultra Violet and X-Ray beamlines are pushing on the Synchrotron Radiation (SR) beam position stability requirements. In the direction of having photon Beam Position Monitor integrated to the orbit closed loop control system, we developed a staggered blades XR BPM and a four-channel current measurement electronics. The BPM mechanic

At the Istituto Nazionale di Fisica Nucleare – Laboratori Nazionali del Sud (INFN-LNS) the commissioning of the high intensity Proton Source for the European Spallation Source (PS-ESS) started some weeks ago. Beam stability at high current intensity is one of the most important parameter for the first steps of the ongoing commissioning. Commissioning plan and preliminary characterization are also

Efter Parisavtalet 2015 har synen på politikens roll i klimatomställningen gradvis förändrats. Klimatfrågan betraktas numera som en viktig del av samhällsutvecklingen snarare än som ett isolerat problem. En central fråga i den nya klimatpolitiken är: hur kan samhällsutvecklingens inriktning påverkas så att ekonomin fortsätter utvecklas samtidigt som klimatmålet om nettonollutsläpp till 2050 nås? F

Sverige behöver tydligare åtgärder och mål för att klara den gröna omställningen. Ryckig och motsägelsefull klimatpolitik riskerar att bromsa processen, skriver tre forskare i en ny SNS-rapport.

Artificial Intelligence Applications for Sustainable Construction presents the latest developments in AI and ML technologies applied to real-world civil engineering concerns. With an increasing amount of attention on the environmental impact of every industry, more construction projects are going to require sustainable construction practices. This volume offers research evidence, simulation result

Concrete carbonation is a prevalent phenomenon that leads to steel reinforcement corrosion in reinforced concrete (RC) structures, thereby decreasing their service life as well as durability. The process of carbonation results in a lower pH level of concrete, resulting in an acidic environment with a pH value below 12. This acidic environment initiates and accelerates the corrosion of steel reinfo

Nowadays, strengthening of reinforced concrete structures with a new class of sustainable materials is the possible solution to retrofit the aged deteriorated structures. It is difficult to predict the capacity of the strengthened (FRP/FRCM) reinforced concrete elements without considering the bond strength. Therefore, the concrete substrate to Fibre-Reinforced Cementitious Matrix (FRCM) bond is a

Combination therapies in metastatic hormone-sensitive prostate cancer (mHSPC), which include the addition of an androgen receptor signaling inhibitor and/or docetaxel to androgen deprivation therapy, have been a game changer in the management of this disease stage. However, these therapies come with their fair share of toxicities and side effects. The goal of this observational study is to report

Copper transporting P-type (P1B-1-) ATPases are essential for cellular homeostasis. Nonetheless, the E1-E1P-E2P-E2 states mechanism of P1B-1-ATPases remains poorly understood. In particular, the role of the intrinsic metal binding domains (MBDs) is enigmatic. Here, four cryo-EM structures and molecular dynamics simulations of a P1B-1-ATPase are combined to reveal that in many eukaryotes the MBD im

With growing urbanization and increase in energy demand for space heating and cooling in buildings, reliability, security, distribution of energy and its efficient end use is of utmost importance particularly when emissions from energy use and indoor thermal comfort of the end users isof question. Numerous solutions have been put forth in the field of effective distribution of thermal

The lead intervention article argues that the new reality of the planetary organic crisis awaits a normative critical social theory of planetary politics, a means of understanding the sharing of relationships within International Relations and an agenda for action in concert found in the normative power approach. The article and subsequent 20th anniversary special issue provide an opportunity to r

Proteinopathy, defined as the abnormal accumulation of proteins that eventually leads to cell death, is one of the most significant pathological features of neurodegenerative diseases. Tauopathies, represented by Alzheimer’s disease (AD), and synucleinopathies, represented by Parkinson’s disease (PD), show similarities in multiple aspects. AD manifests extrapyramidal symptoms while dementia is als

Milk is a nutrient-dense fluid which is essential for a healthy balanced diet. Thermal processing is the dominating approach in the dairy industry to ensure food safety, however, heat treatment can alter both the composition and quality of the milk. The aim of this thesis has been to evaluate the effects of various processing technologies on the nutrient content and physical properties of milk and