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Time-resolved x-ray solution scattering (TR-XSS) is a sub-field of structural biology, which observes secondary structural changes in proteins as they evolve along their functional pathways. While the number of distinct conformational states and their rise and decay can be extracted directly from TR-XSS experimental data recorded from light-sensitive systems, structural modeling is more challengin
Background: New CKD-EPI and EKFC estimated GFR (eGFR) equations usingcreatinine (eGFRcr), cystatin C (eGFRcys) and both (eGFRcr-cys) have sufficientaccuracy for use in clinical practice. A better understanding of the equations, includingtheir performance in race, sex and age subgroups, is important for selection of eGFRequations for global implementation.Methods: We evaluated performance (bias and
The change in constituent order in English is one of the most thoroughly investigated changes in the history of the English language. Even so, there is still disagreement among scholars as to what caused the change. The aim of this article is to argue that it was the influence of the Scandinavians and their language, Old Norse, that caused English to abandon the SOV constituent order and instead a
At first glance, the syntax of ancient Old English appears reminiscent of the syntax of the Present-Day German language. A number of shared syntactic traits such as Subject Object Verb constituent order, Verb Second, and a complicated inflectional system have caused the two languages to be compared by scholars, who often have referred to German as simply a present-day version of the now far-gone O
This open access book shows how geographical scales are made through music.Scales are sets of spatial frames, abstractions or categories that denote the size, proportion, level, extent or hierarchical relations of phenomena. They are neither natural nor neutral but actively produced, with real political effects. But what role do cultural practices play in the production of scale?Phil Dodds address
Future exemplary education should foster inclusive and respectful learning environments to meet new challenges like digital inequality and power concentration. In the new normal of education due to COVID-19, inclusive online disaster risk reduction (DRR) education is essential. Therefore, this article aims to investigate the current status quo of inclusive online and distance DRR education and its
The International Monetary Fund (IMF) provides financial assistance to its member countries in economic difficulties but at the same time requires these countries to reform public policies. In several contexts, these reforms have been at odds with population health and material living standards. While researchers have empirically analyzed the consequences of IMF reforms on health, no analysis has
This paper shows that versions of prioritarianism that focus at least partially on well-being levels at certain times conflict with conventional views of prudential value and prudential rationality. So-called timeslice prioritarianism, and pluralist views that ascribe importance to timeslices, hold that a benefit matters more, the worse off the beneficiary is at the time of receiving it. We show t
Nationalism has trumped solidarity, resulting in unnecessary loss of life and inequitable access to vaccines and therapeutics. Existing intellectual property (IP) regimens, trade secrets and data rights, under which pharmaceutical firms operate, have also posed obstacles to increasing manufacturing capacity, and ensuring adequate supply, affordable pricing, and equitable access to COVID-19 vaccine
Distributive theories evaluate distributions of goods based on candidate recipients’ characteristics, e.g. how well off candidates are, how deserving they are, and whether they fare below sufficiency. But such characteristics vary across possible worlds, so distributive theories may differ in terms of the world which for them settles candidates’ characteristics. This paper examines how distributiv
This paper argues that cost-effectiveness analysis in the healthcare sector introduces a discrimination risk that has thus far been underappreciated and outlines some approaches one can take toward this. It is argued that appropriate standards used in cost-effectiveness analysis in the healthcare sector fail to always fully determine an optimal option, which entails that cost-effectiveness analysi
This paper addresses normative issues that arise in relation to indicators and measures of health impact. With inspiration from Nicole Hassoun's recent proposal, the paper argues and illustrates that those interested in measuring global health impact face questions about how to prioritize among those with ill-health, how to weigh benefits to those who cannot lead minimally good lives against benef
It has recently been argued that in normal decision circumstances no systematic decision method that predicts the likelihood that individuals possess some property can be fair. Either (i) the decision method correctly identifies the relevant property (e.g. recidivism) more often in one subgroup (e.g. black defendants) than another (e.g. white defendants); or (ii) the decision method systematically
This chapter outlines some of the implications of nondeterminacy, however it is explained, for rational choice. The chapter demonstrates that when nondeterminacy is present, some decision strategies actualize dynamic choice problems and resolutional remainder, while others violate basic requirements of rationality, such as basic contraction consistency and acyclicity. It is hypothesized that clues
The possibility of incommensurability indicates that some predicates are different: when two things are incommensurable, neither is determinately better than the other nor are they equally as good as each other. Hence, they are related in some other manner. The possibility of incommensurability can be argued for by referring to the existence of moral dilemmas. Whenever one can make a small improve
A global rules-based order is in flux amid intensifying United States (US)-China geopolitical competition for economic and technological advantage. Concerns about the economic and security risks of dependency on China increasingly shape economic and political decision-making in the West. This paper looks at various national responses to the rise of China in the sphere of scientific collaboration a
