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How do you control a superintelligent artificial being given the possibility that its goals or actions might conflict with human interests? Over the past few decades, this concern– the AGI control problem– has remained a central challenge for research in AI safety. This paper develops and defends two arguments that provide pro tanto support for the following policy for those who worry about the AG
The article demonstrates how international relations (IR) as a discipline has failed to sufficiently attend to caste and casteism as matters of crucial significance for analyzing international, transnational, and global politics. Despite ongoing initiatives to make IR scholars knowledgeable about and attuned to how issues of race and racism directly impact many of the discipline’s core areas of re
Objectives: To assess amide proton transfer weighted (APTw) MR imaging capabilities in differentiating high-grade glial tumors across alpha-thalassemia/mental retardation X-linked (ATRX) expression, tumor-suppressor protein p53 expression (p53), O6-methylguanine-DNA methyltransferase promoter (MGMTp) methylation, isocitrate dehydrogenase (IDH) status, and proliferation marker Ki-67 (Ki-67 index)
Constitutional monarchy offers Iran a politically stable and culturally resonant alternative to partisan republicanism. Grounded in both empirical research and philosophical tradition, it combines symbolic authority with institutional continuity, enabling national unity without authoritarianism. Monarchs function as neutral anchors above political conflict, often at lower public cost and with grea
A role of the immune system in Parkinson’s disease (PD) progression has long been suspected due to the increased frequency of activated glial cells and infiltrating T cells in the substantia nigra. It was previously reported that PD donors have increased T cell responses towards PINK1 and α-synuclein (α-syn), two Lewy body-associated proteins. Further, T cell reactivity towards α-syn was highest c
Background: Lower limb deep vein thrombosis (DVT) is common in emergency departments (EDs) and can be fatal if left untreated due to the risk of progression to pulmonary embolism (PE). In Scandinavia, DVT diagnosis typically relies on ultrasound performed outside the ED in the diagnostic departments. However, international guidelines now recommend combining limited/proximal compression ultrasound
Characterizing subtle cognitive changes in preclinical Alzheimer’s disease (AD) is difficult using traditional neuropsychological assessments. Remote and unsupervised digital assessments can improve scalability, measurement reliability, and ecological validity, enabling the capture of subtle changes. We evaluate such tools for use in preclinical AD, or cognitively unimpaired individuals with abnor
Functional MRI (fMRI) using the blood-oxygen level dependent (BOLD) signal provides valuable insight into grey matter activity. However, uncertainty surrounds the white matter BOLD signal. Apparent diffusion coefficient (ADC) offers an alternative fMRI contrast sensitive to transient cellular deformations during neural activity, facilitating detection of both grey and white matter activity. Furthe
TAR DNA-binding protein 43 (TDP-43) pathology is linked to the neurodegenerative disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington disease (HD). Dysregulation of metabolism and emotion is shared across these disorders and may be caused by hypothalamic pathology. Inclusions with TDP-43 are present in the hypothalamus in clinical ALS, as well as selective lo
Background: Coronavirus disease 2019 (COVID-19) pandemic constituted the largest global health crisis in recent generations. It may also have disrupted the pattern of antimicrobial use (AMU) and subsequently affected the development of antimicrobial resistance (AMR) – a grave human health concern. This study aimed to give an overview of existing AMR surveillance systems and evaluate the impact of
Luminescent properties of KTb(MoO4)2 and K5Tb(MoO4)4 crystals, possessing the same elemental composition but different crystal structures, were studied. The structural arrangement of Tb3+ ions, ordered in KTb(MoO4)2 and disordered in K5Tb(MoO4)4, determines their luminescence properties. Partial lattice disorder of K5Tb(MoO4)4 results in broadened bands of Tb3+ emission and excitation spectra, but
Depressive and anxiety disorders are leading causes of disability globally. Therapist-guided, Internet-delivered cognitive behaviour therapy (ICBT) is an established treatment for depression and anxiety, but a considerable proportion of treated patients do not achieve sufficient improvement. Predicting symptom changes based solely on clinical variables is challenging, and genetic data could offer
We consider the indeterminate Stieltjes moment problem associated with the Stieltjes-Wigert polynomials. After a presentation of the well-known solutions, we study a transformation T of the set of solutions. All the classical solutions turn out to be fixed under this transformation but this is not the case for the so-called canonical solutions. Based on generating func
We show that for a positive linear operator acting in ℓ2 and defined from anxn+1 + bn xn + an-1xn-1 its so-called Friedrichs and Krein extensions may be explicitly characterized by boundary conditions as n → ∞.
We consider indeterminate symmetric moment problems related to birth and death processes with quartic rates. The Nevanlinna matrices are presented and the entire functions B and D are expressed in terms of the trigonometric functions of order 4. Several examples of symmetric and nonsymmetric solutions are given.
We study the Al-Salam-Chihara polynomials when q > 1. Several solutions of the associated moment problem are found, and the orthogonality relations lead to explicit evaluations of several integrals. The polynomials are shown to have raising and lowering operators and a second order operator equation of Sturm-Liouville type whose eigenvalues are found explicitly. We also derive new measures with re
The symmetric Al-Salam-Chihara polynomials for q > 1 are associated with an indeterminate moment problem. There is a self-adjoint second-order difference operator on 2(Z) to which these polynomials are eigenfunctions. We determine the spectral decomposition of this self-adjoint operator. This leads to a class of discrete orthogonality measures, which have been obtained previously by Christiansen a
We consider Jacobi matrices whose essential spectrum is a finite union of closed intervals. We focus on Szego{double acute}'s theorem, Jost solutions, and Szego{double acute} asymptotics for this situation. This announcement describes talks the authors gave at OPSFA 2007.
The generalized Stieltjes-Wigert polynomials depending on parameters 0≤;p<1 and 0
Let e ⊂ ℝ be a finite union of disjoint closed intervals. We study measures whose essential support is e and whose discrete eigenvalues obey a 1/2-power condition. We show that a Szego{double acute} condition is equivalent to (this includes prior results of Widom and Peherstorfer-Yuditskii). Using Remling's extension of the Denisov-Rakhmanov theorem and an analysis of Jost functions, we provide a
