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As populations age and multimorbidity becomes increasingly prevalent, the demand for high risk surgical procedures continues to rise. Although short term surgical outcomes in Sweden are generally favourable, evidence regarding long term morbidity and mortality following non cardiac surgery remains limited. This thesis investigates perioperative determinants of long term outcomes, with the aim of i
AIM: Preoperative anaemia is a well-established risk factor for poor outcomes. However, the impact of postoperative haemoglobin (Hb) levels on long-term outcomes, including mortality and cardiovascular events, remains uncertain. This study aims to assess the independent association between postoperative nadir Hb levels and long-term outcomes, considering the potential interaction with preoperative
Background: Procalcitonin (PCT) is a biomarker used to differentiate between viral and bacterial infections, though the underlying mechanisms are not yet fully understood. This study aimed to identify genetic variants associated with plasma PCT concentrations and explore the associations of genetically predicted PCT with a wide range of disease related traits in a PheWAS. Methods: We conducted GWA
Articular cartilage undergoes structural and compositional changes during osteoarthritis (OA), one of the most common joint diseases. Earlier research shows that these changes are dependent on species and joint site, and they also vary across cartilage depth. In this study, we analyzed the depth-wise proteoglycan and collagen contents, as well as collagen fibril orientation angle and fibril alignm
Rational & Objective: Sarcopenia is linked to increased morbidity and mortality in chronic kidney disease (CKD), but its definition and assessment vary considerably across studies. This study evaluated the technical feasibility of magnetic resonance imaging (MRI)–based assessment of adverse muscle composition (AMC)—defined as low muscle volume and high fat infiltration—and its associations wit
Accurate, high-resolution global land use and land cover (LULC) mapping is crucial for environmental monitoring, but remains challenging when relying solely on multispectral data. Most existing global LULC mapping studies rely exclusively on multispectral observations, and even those that incorporate synthetic aperture radar (SAR) data often fail to fully exploit the information it provides. SAR p
Abstract in Polish:Artykuł omawia trzy skandynawskie filmy dokumentalne: Zaćmienie duszy (2000) fińskiej reżyserki Marji Pensali, Tankograd (2010) autorstwa Duńczyka Borisa Bertrama oraz Nadzy z Petersburga (2010) w reżyserii duńskiej twórczyni Ady Bligaard Søby. Każdy z dokumentów to portret wybranego miasta w Rosji i jego mieszkańców. Odwołując się do koncepcji takich jak „rosyjska dusza”, bytieThe article discusses three documentaries made since 2000 by Scandinavian filmmakers: the Finnish director Marja Pensala’s The Eclipse of the Soul (2000) and two films by Danish authors: Boris Bertram’s Tankograd (2010) and Ada Bligaard Søby’s The Naked of Saint Petersburg (2010). All the films are portraits of Russian cities and their residents. In my study, I draw on concepts such as the “Russia
Background and importance: The major risk factor for vermilion lip squamous cell carcinoma (vlSCC) is excessive sunlight exposure. Population-based studies on treatment and outcome are lacking. Methods: This is a nation-wide, population-based study of treatment and outcome from prospectively recorded data for 2,111 vlSCC registered in the Swedish Head and Neck Cancer Register (SweHNCR) diagnosed 2
Epilepsy affects more than 50 million individuals worldwide, and approximately one-third of patients remain refractory to existing antiseizure medications. Advances in gene therapy and genome editing have opened new possibilities for disease-modifying interventions that directly target the molecular and circuit-level mechanisms underlying epileptogenesis. Recent progress in central nervous system
The International Society for Heart and Lung Transplantation Consensus for Perioperative Utilization of Extracorporeal Life Support in Lung Transplantation consists of 111 Delphi-derived statements across 3 separate manuscripts. These statements aim to provide comprehensive phase-of-care recommendations for international multidisciplinary teams to use in their clinical practice from time of recipi
Access to detailed network data is often constrained by access-controlled datasets or by extensive manual labour. Using aerial imagery and a simplified OpenStreetMap road-level graph, a novel approach is proposed to extract lane-level road topology graphs at signalized intersections based on detection of common road objects, classification of lane attributes, and a simultaneous lane-to-lane connec
The use of extracorporeal life support (ECLS) throughout the perioperative phase of lung transplantation requires nuanced planning and execution by an integrated team of multidisciplinary experts. To date, no multidisciplinary consensus document has examined the perioperative considerations of how to best manage these patients. To address this challenge, this perioperative utilization of ECLS in l
BakgrundPalliativ vårdavdelning är en plats som ofta präglas av sorg, smärta och svåra beslut. För patienter och deras anhöriga kan det vara svårt att hitta utrymme för glädje och lättnad, och för vårdpersonalen innebär det dagliga mötet med döden en emotionell påfrestning. Sedan hösten 2023 har denpalliativa avdelningen i Lund fått oväntad men värdefull förstärkning: varannan vecka besöker två sj
Ageing in the human brain is a major risk factor for most neurodegenerative diseases. Yet the cell-type-specific molecular changes that contribute to this risk remain poorly understood. This thesis investigates cell-type-specific changes across multiple levels of molecular regulation and their roles in physiological and pathophysiological brain ageing. Using single-nucleus RNA sequencing of postmo
