Filetype
We recently reported that HIV-1 infection can be inhibited by innate antimicrobial components of human seminal plasma (SP). Conversely, naturally occurring peptidic fragments from the SP-derived prostatic acid phosphatase ( PAP) have been reported to form amyloid fibrils called "SEVI'' and enhance HIV-1 infection in vitro. In order to understand the biological consequence of this proviral effect,
The consequences of adopting other definitions of the concepts of sum and convergence of a series are discussed in the light of historical and epistemological contexts. We show that some divergent series appearing in the context of renormalization methods cannot be assigned finite values while preserving a minimum of consistency with standard summation, without at the same time obtaining contradic
Objective To develop evidence-based recommendations for the diagnosis of knee osteoarthritis (OA). Methods The multidisciplinary guideline development group, representing 12 European countries, generated 10 key propositions regarding diagnosis using a Delphi consensus approach. For each recommendation, research evidence was searched systematically. Whenever possible, the sensitivity, specificity a
Transient evoked otoacoustic emissions (TEOAEs) have been analyzed for objective assessment of hearing function and monitoring of the influence of noise exposure and ototoxic drugs. This paper presents a novel application of the Hilbert-Huang transform (HHT) for detection and time-frequency mapping of TEOAEs. Since the HHT does not distinguish between signal and noise, it is combined with ensemble
Background: Potato late blight caused by the oomycete pathogen Phytophthora infestans can lead to immense yield loss. We investigated the transcriptome of Solanum tubersoum (cv. Desiree) and characterized the secretome by quantitative proteomics after foliar application of the protective agent phosphite. We also studied the distribution of phosphite in planta after application and tested transgeni
Background: Phosphoinositide 3-kinases (PI3Ks) are involved in a number of biologic responses. Recent preclinical studies demonstrated that the PI3K-dominant signal pathway could play an important role in the development of acute lung injury, although the mechanism remains unclear. Methods: CD-1 mice were administered different PI3K inhibitors either intranasally or intragastrically once a day for
What happens when cultural analysis enters the world of applied research and academics become consultants working with corporations and public institutions? The divide between academic research and commercial ethnography has often hampered communication and critical exchanges between these two worlds. In this paper we look at the experiences of consultants, drawing on Danish and Swedish examples.
Sammandrag. Uppsatsen är en studie av syntaktiska, semantiska och pragmatiska egenskaper hos konstruktionen x-som-x. Undersökningen tar sin utgångspunkt i den interaktionella grammatiken, och som jämförelsematerial används tidigare undersökningar av konstruktionen x-och-x. Exempel på x-som-x är hämtade från olika källor på Internet, såsom bloggar och diskussionsforum. I avsnittet om konstruktionen
Background: Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects. BBR3464 is a promising trinuclear platinum anticancer agent, which is a polyamine mimic. The aim was to investigate the influence of polyamine pool reduction on the cytotoxic effe
We present a method aimed at reducing uncertainties and instabilities when characterizing materials in waveguide setups. The S-parameters for a rectangular waveguide loaded with a rectangular sample block are measured for three different sample orientations, and the corresponding geometries are modeled in a finite element program, taking any material parameters as input. The material parameters of
We present a detailed experimental and numerical study of the structural and dynamical properties of salt-free lysozyme solutions. In particular, by combining small-angle X-ray scattering (SAXS) data with neutron spin echo (NSE) and rheology experiments, we are able to identify that an arrest transition takes place at intermediate densities, driven by the slowing down of the cluster motion. Using
Klädgalgen är en relativt sentida företeelse i de svenska hemmen. Artikeln diskuterar galgen såsom "massprodukt" men också dess, i många fall, mycket säregna, rentav unika, utformning och estetik. Artikeln vill lyfta fram att galgen, ett obetydligt och ofta undangömt föremål, inte sällan har ägnats en stor omtanke. Vissa galgar är helt unika. Även ett enkelt vardagsföremål, såsom en galge, uttryck
We previously demonstrated that the overall incretin effect and the β-cell responsiveness to glucagon-like peptide-1 (GLP1) are increased in insulin-resistant mice and may contribute to the upregulated β-cell function. Now we examined whether this could, first, be explained by increased islet GLP1 receptor (GLP1R) protein levels and, secondly, be leveraged by G-protein-coupled receptor 119 (GPR119
Background: In the everyday surgical life, staff may experience that patients with Alcohol Use Disorders (AUDs) seem reluctant to participate in alcohol intervention programs. The objective was therefore to assess acceptance of screening and intervention as well as adherence to the intervention program among emergency department (ED) and surgical patients with AUDs. Methods: A systematic literatur
Granular sands are characterized and modeled here by explicitly exploiting the discrete-continuum duality of granular matter. Grain-scale kinematics, obtained by shearing a sample under triaxial compression, are coupled with a recently proposed multiscale computational framework to model the behavior of the material without resorting to phenomenological evolution (hardening) laws. By doing this, c
Collection and recycling systems for small waste electrical and electronic equipment (WEEE) in Europe has been developed based on the 2003 EU Directive on Waste Electrical and Electronic Equipment (WEEE Directive), which was transposed into the national laws of EU Member States. With the growing recognition on the potential for small WEEE to supply mateirals that are critical to the continued grow
White horses frequently suffer from malign skin cancer and visual deficiencies owing to their high sensitivity to the ultraviolet solar radiation. Furthermore, in the wild, white horses suffer a larger predation risk than dark individuals because they can more easily be detected. In spite of their greater vulnerability, white horses have been highly appreciated for centuries owing to their natural
