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Galectins are a medically important family of small, soluble carbohydrate-binding proteins that have been implicated in a wide variety of diseases, and are therefore targets for the development of new drugs. Many X-ray crystal structures of small molecules in complex with galectins have been determined and have given invaluable information on how natural ligands and synthetic inhibitors are recogn
Treatment of haemophilia A/B patients comprises factor VIII (FVIII) or factor IX (FIX) concentrate replacement therapy, respectively. FVIII and FIX activity levels can be measured in clinical laboratories using one-stage activated partial thromboplastin time (aPTT)-based clotting or two-stage chromogenic factor activity assays. We discuss strengths and limitations of these assays, providing exampl
A novel model-independent Lévy imaging method is employed for reconstruction of the elastic pp and pp¯ scattering amplitudes at low and high energies. The four-momentum transfer t-dependent elastic slope B(t), the nuclear phase φ(t) as well as the excitation function of the shadow profile P(b) have been extracted from data at ISR, Tevatron and the LHC energies. We found qualitative differences in
Objectives: With increased long-term survival after traumatic brain injury (TBI), there is a need to understand the life situation many years after the injury. In this study, we have assessed persons on average 16 years after their injury and determined changes over 6 years in overall outcome, living condition, marital status and vocational situation, and in their functioning and disability. Mater
Purpose: Postoperative bleeding after thyroid surgery remains a potentially lethal complication. Outpatient thyroidectomy is an increasing trend in the high volume centers. There is a need to identify risk factors for postoperative bleeding in order to select proper patients for outpatient thyroidectomy. This study aimed to investigate this issue using a national population-based register. Materia
Patient participation in forensic psychiatric settings seems to be complex by nature, and previous studies show that patients rate their participation as lower in this context compared to general psychiatric contexts. Studies on caregivers’ perspective could provide a clearer picture of the components and possibilities of patient participation in forensic psychiatry. The aim of the study is to des
Parental care in birds varies among species and geographic regions. Incubation behavior influences embryonic development rate and varies substantially among species. We studied attendance at the nest by videoing nests or collecting data from the literature for 112 species in north temperate and lowland tropical sites, then associated patterns of incubation on- and off-bouts with species and enviro
Hypothalamic pathology, metabolic dysfunction and psychiatric symptoms are part of Huntington disease (HD), which is caused by an expanded CAG repeat in the huntingtin (HTT) gene. Inactivation of mutant HTT selectively in the hypothalamus prevents the development of metabolic dysfunction and depressive-like behavior in the BACHD mouse model. The hypothalamic paraventricular nucleus (PVN) is implic
Photofragmentation laser-induced fluorescence (PFLIF) is for the first time performed based on picosecond laser pulses for detection of hydroperoxyl radicals (HO2) in a stoichiometric laminar methane/air flame. Photofragmentation is performed with a pump laser pulse of 80 ps duration and a wavelength of 266 nm, whereupon the produced OH photofragments are detected by a second picosecond probe lase
This work presents a Scheimpflug lidar system which was employed for atmospheric aerosol monitoring in southern Sweden. Atmospheric aerosol fluctuation was observed around rush-hour. The extinction coefficient over 6 km was retrieved, i.e., 0.15 km-1, by employing the slop-method during the time when the atmosphere was relatively homogenous. The measurements successfully demonstrate the potential
The thesis discusses the licensing system of the Creative Commons from the perspective of the theory of the commons mostly as formulated by Elinor Ostrom. The work starts by describing the concepts and theory of common pool resources and regime of the commons for production and distribution of these resources. The main characteristics for successful traditional commons – efficiency, equity and sus
Self-propelled colloidal objects, such as motile bacteria or synthetic microswimmers, have microscopically irreversible individual dynamics—a feature they share with all living systems. The incoherent behavior of individual swimmers can be harnessed (or “rectified”) by microfluidic devices that create systematic motions that are impossible in equilibrium. We present a computational proof-of-concep
En ”kolloidal pump”, simulerad i datorn, visar hur aktivitet kan användas för att skapa nya designprinciper för kolloidala material genom att vi inte längre är bundna av termodynamikens lagar.
We show that the two problems of computing the permanent of an n*n matrix of poly(n)-bit integers and counting the number of Hamiltonian cycles in a directed n-vertex multigraph with exp(poly(n)) edges can be reduced to relatively few smaller instances of themselves. In effect we derive the first deterministic algorithms for these two problems that run in o(2^n) time in the worst case. Classic pol
Lokshtanov, Marx, and Saurabh SODA 2011 proved that there is no (k-epsilon)^pw(G)poly(n) time algorithm for deciding if an n-vertex graph G with pathwidth pw admits a proper vertex coloring with k colors unless the Strong Exponential Time Hypothesis (SETH) is false, for any constant epsilon>0. We show here that nevertheless, when k>lfloor Delta/2 rfloor + 1, where Delta is the maximum degree in th
Rice husk, which considered a waste, has a high level of silicon. This paper investigates the use of carbonized rice husk in water purification. The carbonization was done using a handmade carbonizer. The preparation process starts with the production of a precursor that is rich in carbon through the pyrolysis of the rice husk in an inert atmosphere. The results show an important contribution of t
Usually, allocation of resources is an optimization problem which involves a variety of conflicting economic, social, and ecological objectives. In such a process, advanced geographic analyst tool for manipulation of spatial data and satisfaction of multiple objectives is essential to the success of decision-making. The present research intends to demonstrate the application of a multiobjective op
