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Receptors, transporters, and ion channels are important targets for therapy development in neurological diseases, but their mechanistic role in pathogenesis is often poorly understood. Gene editing and in vivo imaging approaches will help to identify the molecular and functional role of these targets and the consequence of their regional dysfunction on the whole-brain level. We combine CRISPR-Cas9
Knowledge about writers’ eye movements and their effects on the writing process, and its product – the finally edited text—is still limited. Previous research has demonstrated that there are differences between reading texts written by someone else and reading one’s own emerging text and that writers frequently look back into their own texts. (Torrance, Johansson, et al., 2016). For handwriting, A
Cooperative breeding allows the costs of parental care to be shared, but as groups become larger, such benefits often decline as competition increases and group cohesion breaks down. The counteracting forces of cooperation and competition are predicted to select for an optimal group size, but variation in groups is ubiquitous across cooperative breeding animals. Here, we experimentally test if gro
Correlations between mean transverse momentum [pT] and anisotropic flow coefficients v2 or v3 are measured as a function of centrality in Pb–Pb and Xe–Xe collisions at sNN=5.02 TeV and 5.44 TeV, respectively, with ALICE. In addition, the recently proposed higher-order correlation between [pT], v2, and v3 is measured for the first time, which shows an anticorrelation for the presented centrality ra
In this article we discuss how two types of popular romances – the desert romance and the governess romance – have blended into what we refer to as the desert-governess romance. In the world of romance, the governess and the sheikh may be an odd couple but they do make good bedfellows. Etymologically speaking, the governess (“A woman who holds or exercises authority” (OED)) is the perfect love matIn this article we discuss how two types of popular romances – the desert romance and the governess romance – have blended into what we refer to as the desert-governess romance. In the world of romance, the governess and the sheikh may be an odd couple but they do make good bedfellows. Etymologically speaking, the governess (“A woman who holds or exercises authority” (OED)) is the perfect love mat
Astrophysical neutrinos are excellent probes of astroparticle physics and high-energy physics. With energies far beyond solar, supernovae, atmospheric, and accelerator neutrinos, high-energy and ultra-high-energy neutrinos probe fundamental physics from the TeV scale to the EeV scale and beyond. They are sensitive to physics both within and beyond the Standard Model through their production mechan
Background: In ultra-rare sarcomas (URS) the conduction of prospective, randomized trials is challenging. Data from retrospective observational studies (ROS) may represent the best evidence available. ROS implicit limitations led to poor acceptance by the scientific community and regulatory authorities. In this context, an expert panel from the Connective Tissue Oncology Society (CTOS), agreed on
Nästa år ska regeringen enligt klimatlagen presentera en handlingsplan för hur Sverige ska nå klimatmålen. Minst ett dussin myndigheter har bidragit med underlag. Men inte ens om samtliga förslag i dessa rapporter genomförs kommer det att räcka för att fylla det gap som har uppstått med den nya regeringens politik, skriver Klimatpolitiska rådet.
Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adoptin
Mainstreaming of ecosystem service approaches has been proposed as one path toward sustainable development. Meanwhile, critics of ecosystem services question if the approach can account for the multiple values of ecosystems to diverse groups of people, or for aspects of inter- and intra-generational justice. In particular, an ecosystem service approach often overlooks power dimensions and capabili
Characterization of material structure with X-ray or neutron scattering using e.g. Pair Distribution Function (PDF) analysis most often rely on refining a structure model against an experimental dataset. However, identifying a suitable model is often a bottleneck. Recently, automated approaches have made it possible to test thousands of models for each dataset, but these methods are computationall
In this study, a model „ADM606M Portable Multifunction Ratemeter /Scalar“ (Gamma GP110 Detector) was used to estimate the effective dose rate in (µSv.h-1). The data were analyzed for three specified hours per day (9:00 a.m., 11:00 a.m., and 1:00 p.m.) from January 2009 to June 2016. In July 2019, the gamma scout radiation meter (dosimeter) was used to measure the outdoor gamma effective dose rate
Introduction: Impaired functioning is seen in patients following replantation surgery to the thumb or fingers. Our aim was to explore long-term consequences and adaptation in daily life after a thumb and/or multiple finger amputation followed by replantation surgery during young age. Methods: Semi-structured interviews were conducted with nine recruited individuals and analysed using content analy
A direct search for Higgs bosons produced via vector-boson fusion and subsequently decaying into invisible particles is reported. The analysis uses 139 fb−1 of pp collision data at a centre-of-mass energy of s = 13 TeV recorded by the ATLAS detector at the LHC. The observed numbers of events are found to be in agreement with the background expectation from Standard Model processes. For a scalar Hi
Physiochemical degradation of therapeutic proteins in vivo during plasma circulation after administration can have a detrimental effect on their efficacy and safety profile. During drug product development, in vivo animal studies are necessary to explore in vivo protein behaviour. However, these studies are very demanding and expensive, and the industry is working to decrease the number of in vivo
Research on what makes people walk/cycle for tourism is significantly understudied in relation to smart app use among Asians. To bridge this gap, this work proposes and verifies an integrated research framework that includes environment and health factors, along with heavy versus non-heavy users of smart apps based on PLS-SEM and fsQCA. Public health has a positively significant impact on behavior
This research evaluates the impacts of flexible demand-side management on electricity load and indoor thermal comfort under extreme weather conditions, focusing on elderly people. For this purpose, an elderly care center in Alesund, Norway is chosen as the pilot building. A high spatiotemporal resolution building energy model is developed including thermal zones and energy systems, verified agains
