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For the first time, reductions in cerebral β-amyloid pathology load and rate of cognitive and functional decline have been achieved in Alzheimer's disease, through pharmacological intervention in randomised controlled trials. However, the results from phase 3 randomised controlled trials of anti-β amyloid monoclonal antibodies are interpreted in different ways, with some experts supporting a clini
Subungual epidermoid inclusions (SEI) are small epithelial inclusions, sometimes solid but mostly with central keratinization of the onycholemmal type without a granular layer. Exceptionally, they become large enough to produce symptoms such as pain or swelling of the nail bed, resulting in subungual keratosis, onycholysis, or a dystrophic nail plate. Herein, we report a further case of SEI in a f
Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individuals, and a leading source of health and social care expenditure for society. Before the advent of biomarkers, post-mortem examination was the only method available to establish a definitive diagnosis.
Reflection seismic data were acquired in the Sudret area of Gotland between 6 and 13 November 2023. Objectives of the survey were to obtain images of the subsurface down to the Precambrian basement in the vicinity of two cored boreholes that had been drilled earlier down to about 800 m. The seismic profiles were positioned to provide a better understanding of the sedimentary strata and local struc
Aims Our objective was to assess changes in the birth prevalence of CHD over a half-century in a high-resource, nationwide setting, as well as changes in the prevalence of cardiac interventions in this population. Methods The Swedish National Patient and Cause of Death registers were linked to estimate the annual rates of CHD and cardiac and results interventions among live-born infants from 1970
Immunoglobulin G4-related disease (IgG4-RD), which was initially identified as a type of autoimmune pancreatitis around the year 2000, is now widely acknowledged to be a systemic sickness. Based on both general and organ-specific criteria, alongside laboratory measurements of IgG4-subtype, the diagnosis is made. The diagnosis requires, however, a heightened index of suspicion, especially given the
This study addresses a challenging problem of predicting mean annual precipitation across arid and semi-arid areas in northern Algeria, utilizing deterministic, geostatistical (GS), and machine learning (ML) models. Through the analysis of data spanning nearly five decades and encompassing 150 monitoring stations, the result of Random Forest showed the highest training performance, with R square v
This paper proposes a methodology to include induction machine (IM) in an optimization scheme for EV powertrains using Particle Swarm Optimization (PSO) as the optimization algorithm. The IM model is developed based on finite element analysis (FEA) and all the losses are estimated. The main objective is to generate a large database of base designs in a computationally efficient but accurate way. T
Residual stress is of great importance on the fatigue life of components; nevertheless, most of the simulations of turning operation focus on the first cut and ignore the evolution of residual stress in sequential cutting. The present study aims to explore the surface residual stress profile along the feed direction during longitudinal turning, to understand the impact of sequential cuts on turnin
Cuerpo-territorio is a method stemming from Latin American geography, which recognizes the centrality of situated and embodied experiences as a form of knowing. We engaged with this method in the classroom to understand how students through their embodied and situated experiences had absorbed a post-development geographic course content and how these notions had remained with them. Given that emot
Researchers have shown a substantial amount of interest in smart tourism. Despite the fact that smart tourism has been a popular research topic in the tourism and hospitality industries over the past decade, research on this concept is still at a relatively early stage. This research extracted 50 studies (from 2015 to 2023) on the definition of smart tourism using a systematic review and performed
This short paper serves as an introduction to the special issue published in Geografiska Annaler B on the topic of innovation in the periphery. In addition to summarizing the main contributions included within the special issue, this piece reflects on the current state of knowledge in this sub-field and where the gaps are that need to be filled by research going forwards. This collection represent
Aims/hypothesis: Roux-en-Y gastric bypass surgery (RYGB) frequently results in remission of type 2 diabetes as well as exaggerated secretion of glucagon-like peptide-1 (GLP-1). Here, we assessed RYGB-induced transcriptomic alterations in the small intestine and investigated how they were related to the regulation of GLP-1 production and secretion in vitro and in vivo. Methods: Human jejunal sample
Emanating from theories on media and sport this study analyses two cross-country races from the 1980s and two from 2015. The study shows that the broadcasts have evolved into something that the spectators on the ground cannot, to the same degree, experience, including increased and more tangible use of graphics, a higher editing frequency, an increased amount of and more mobile cameras yielding mo
”Han talte de om som en hjälte” examines the use of parody and satire in the Swedish comedy series S*M*A*S*H (1990) and Pistvakt (1998–2000) as well as the feature film Pistvakt – En albinovästern från de vita vidderna (2005). By analyzing how the series illustrates performative masculinity from the definitions of Judith Butler in Gender Trouble (1990), conclusions on whether they destabilize norm“Han talte de om som en hjälte ”examines the use of parody and satire in the Swedish comedy series S*M*A*S*H (1990) and Pistvakt (1998–2000) as well as the feature film Pistvakt – En albinovästern från de vita vidderna (2005). By analyzing how the series illustrates performative masculinity from the definitions of Judith Butler in Gender Trouble (1990), conclusions on wheth
Background: Continuity of care is considered important for results of treatment of serious mental illness (SMI). Yet, evidence of associations between relational continuity and different medical and social outcomes is sparse. Research approaches differ considerably regarding how to best assess continuity as well as which outcome to study. It has hitherto been difficult to evaluate the importance o
