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Thyroid hormone (TH) signaling plays a major role in the development, energy homeostasis, and metabolism of most tissues. Recent studies have identified THs as drivers of prostate cancer (PCa) development and progression. We reported that the T3-scavenger protein µ-crystallin (CRYM) regulates the development and progression of PCa and that this involved crosstalk with androgen receptor (AR) signal

This editorial introduces the special feature’s main objective: to provide latest research findings on the dynamics between environmental protection and post-conflict peacebuilding processes after internal armed conflicts. In the feature, we propose a broad understanding of environmental peacebuilding that takes all cycles of the peacebuilding process into account and puts stronger emphasis on the

Seizure-related homolog protein 6 (SEZ6) is a cell surface type 1 transmembrane protein involved in neuronal development, the expression of which in adult tissues is almost exclusively limited to the central nervous system. Aberrant expression of SEZ6 has been associated with neurodevelopmental and psychiatric disorders including epilepsy, schizophrenia, and Alzheimer disease. More recently, SEZ6

In contemporary Sri Lanka, nationalistic Sinhala organizations like Bodu Bala Sena (BBS) have made a great impact on the debate over what role Buddhism should play in the country. BBS claims that Islam is a non-Sri Lankan element in the Buddhist majority society, campaigning on such issues on social media between 2012 and 2014. This led Sri Lankan Muslim organizations to use social media to counte

De senaste decennierna har inneburit stora omvälvningar av den svenska offentligheten. Internets genomslag, de sociala medierna och smarta telefoner har i grunden förändrat hur vi tar till oss information om aktuella händelser och kunskap om det förflutna. Traditionell läsning har haft svårt att konkurrera med audiovisuella medier i den nya uppmärksamhetsekonomin. Vilka roller historiker ska ha oc

Recent progress in “water-in-salt” electrolytes (WiSEs) and “hybrid aqueous/non-aqueous electrolytes (HANEs)” made broader choices of active material in aqueous Li-ion batteries (ALIBs), because of their compared to standard aqueous electrolytes expanded electrochemical stability windows (ESWs). Exploring high energy density ALIBs is a consequently meaningful research topic. However, the formation

Rechargeable aqueous zinc batteries (AZBs) have been recognized as attractive energy storage devices because of their intrinsic superiorities, e. g., high safety, low material cost and environmental benignity. However, challenges such as dendrite formation on the surface of zinc (Zn) anode, poor reversibility of Zn plating/stripping and short circuit of the cell, having detrimental impact on cycle

The development of high safety lithium-ion batteries (LIBs) is greatly impeded by the flammability and leakage concerns of typical organic solvent-based electrolytes. As one of the alternative classes of electrolytes, hydrogel electrolytes exhibit high safety, high flexibility, low cost, and are benign to the environment. However, the narrow electrochemical stability window (ESW) of typical hydrog

The formation of solid-electrolyte interphase (SEI) in “water-in-salt” electrolyte (WiSE) expands the electrochemical stability window of aqueous electrolytes beyond 3.0 V. However, the parasitic hydrogen evolution reaction that drives anode corrosion, cracking, and the subsequent reformation of SEI still occurs, compromising long-term cycling performance of the batteries. To improve cycling stabi

The introduction of “water-in-salt” electrolyte (WiSE) concept opens a new horizon to aqueous electrochemistry that is benefited from the formation of a solid-electrolyte interphase (SEI). However, such SEI still faces multiple challenges, including dissolution, mechanical damaging, and incessant reforming, which result in poor cycling stability. Here, we report a polymeric additive, polyacrylamid

Context: AI technologies are increasingly embedded in products and software engineering processes of industrial IoT, autonomous systems, and cyber-physical systems. It is therefore essential to ensure alignment with safety, reliability, and ethical standards. However, practical software engineering methods for managing misalignment risks remain underdeveloped. Objective: This study aims to explore

Context. Strongly lensed quasars are fundamental sources for cosmology. The Gaia space mission covers the entire sky with the unprecedented resolution of 0.18âà € ³ in the optical, making it an ideal instrument to search for gravitational lenses down to the limiting magnitude of 21. Nevertheless, the previous Gaia Data Releases are known to be incomplete for small angular separations such as thos

Background: Bone and mineral disorders are common in patients with chronic kidney disease (CKD), leading to poor quality of life, high fracture risk, and increased morbidity and cardiovascular mortality. Parathyroid hormone (PTH) and bone-specific alkaline phosphatase (bALP) are frequently used to assess bone turnover, but markers such as procollagen type I N-terminal propeptide (intact PINP) and

Lateral spinal cord injury including lateral hemisection (LHS) leads to asymmetric postural and motor deficits. After traumatic brain injury, asymmetric postural deficits are partly developed through activation of opioid receptors. We here characterized the effects of LHS on hindlimb postural asymmetry (HL-PA), a proxy for neurological impairments, and assessed the involvement of opioid system. In

Developing and validating sensitive visual read algorithms for assessing Alzheimer disease-related tau in tau PET imaging is imperative, considering the implementation of the methodology in clinical practice and trials. Our aim was to compare 2 visual read algorithms for tau PET images to semiquantitative measurements and plasma phospho-tau 217 (p-tau217) status. Methods: In total, 1,654 participa

Distinct from the pulmonary circulation, the human respiratory mucosa is supplied by highly responsive, superficial, systemic microcirculations. In the early symptomatic phase of mucosal infections, circulating peptides-proteins of all sizes are released just beneath the epithelium and will soon appear on the mucosal surface. The traditional view is that mucosal injury must be involved in this pla

Changes in pupil size can lead to apparent gaze shifts in data recorded with video-based eye trackers in the absence of physical eye rotation. This is known as the pupil-size artifact (PSA). While the PSA is widely reported in desktop eye trackers, it is unknown whether and to what extent it occurs in head-mounted eye trackers. In this paper, we examined the effects of pupil size variations on eye

Word accents are restricted by a word’s morphological structure but also distinguish lexical meanings in minimal pairs. We investigated how early tonal information carried by morphophonemic word accents influences rapid lexical access in native speakers. We also asked whether tone-bearing words are decomposed into morphemes and word accents, or retrieved holistically via full-form neural represent

Sodium ion batteries have been considered as promising alternatives to lithium ion batteries for large-scale renewable energy and smart grids applications due to their low cost and rich resources. However, critical drawbacks such as low energy density and poor stability are hindering their development and application. In this work, a stable symmetric sodium ion cell using sodium vanadium pyrophosp