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The cartilage aggrecan proteoglycan is crucial for both skeletal growth and articular cartilage function. A number of aggrecan (ACAN) gene variants have been linked to skeletal disorders, ranging from short stature to severe chondrodyplasias. Osteochondritis dissecans is a disorder where articular cartilage and subchondral bone fragments come loose from the articular surface. We previously reporte

Den tredje februari 2022 anordnades en workshop vars syfte var att diskutera policy rekommendationer som skulle kunna främja utvecklingen av energigemenskaper i Sverige. Under workshopen diskuterades energigemenskapers möjlighet att äga nät, incitamentsstruktur för att utveckla energigemenskaper och huruvida energiföretag bör tillåtas vara medlemmar i energigemenskaper. Deltagarna i workshopen var

BACKGROUND: Asthma is the most frequent chronic disease in children. One of the most replicated genetic findings in childhood asthma is the ORMDL3 gene confirmed in several GWA studies in several paediatric populations.OBJECTIVES: The purpose of this study was to analyse ORMDL3 variants and expression in childhood asthma in the Polish population.MATERIALS AND METHODS: In the study we included 416

This article explores the discourses, actors, and cross-border exchanges thatshape the broader landscape of contemporary transnational feminist andqueer non-governmental organizations (NGOs). While several studies havepointed to the co-opted role of NGOs, fewer have explored the potential forNGOs to influence the conditions under which they operate. That is what thisarticle sets out to do, with th

Wanting to help others and benefit society in one’s future career are examples of communal career goals. Raising these goals in youth should increase interest in HEED-occupations (Healthcare, Early Education, Domestic, and the Domestic fields) which are strongly gender-skewed and face labor shortage. Research has yet to find ways to increase communal career goals. In this study, we test the novel Wanting to help others and benefit society in one’s future career are examples of communal career goals. Raising these goals in youth should increaseinterest in HEED-occupations (Healthcare, Early Education, Domestic, and the Domestic fields) which are strongly gender-skewed and face labor shortage.Research has yet to find ways to increase communal career goals. In this study, we test the novel hy

Development of islet autoimmunity precedes the onset of type 1 diabetes in children, however, the presence of autoantibodies does not necessarily lead to manifest disease and the onset of clinical symptoms is hard to predict. Here we show, by longitudinal sampling of islet autoantibodies (IAb) to insulin, glutamic acid decarboxylase and islet antigen-2 that disease progression follows distinct tra

“The definition of insanity is doing the same thing over and over again but expecting different results.” This quote by Albert Einstein highlights our need for new formats of communication to address the knowledge-action gap regarding climate change and other sustainability challenges. This includes reflection, and communication spaces, as well as methods and approaches that can catalyze the emerg

The last half-a-century has seen a marked demand for authentic citizen participation in public policy-and decision-making, not least in the field of sustainability. The depth and forms of citizen engagement in nature-based solutions (NBS), for example, and how such participation shapes their trajectories is gaining increasing attention. In this paper, we analyze current forms and implications of c

The concept of sustainable lifestyles is said to have reached the limits of its usefulness. As commonly understood, it impedes an effective response to our increasingly complex world, and the associated societal challenges. In this context, the emerging paradigm of relationality might offer a way forward to renew our current understanding and approach. We explore this possibility in this study. Fi

Background and Aims: We aimed to compare the risk of frailty in older adults with incident inflammatory bowel disease (IBD) and matched non-IBD comparators and assess the association between frailty and future hospitalizations and mortality. Methods: In a cohort of patients with incident IBD ≥60 years of age from 2007 to 2016 in Sweden identified using nationwide registers, we defined frailty usin

Manipulating light on the nanometer scale is a challenging topic not only from a fundamental point of view, but also for applications aiming toward the design of miniature optical devices. Nanoplasmonics is a rapidly emerging branch of photonics, which offers variable means to manipulate light using surface plasmon excitations on metal nanostructures. As a spectroscopic phenomenon discovered nearl

At their core, the UN Climate Change conferences known as “COPs” are the primary international venue for negotiating how countries should act and cooperate to avoid dangerous climate change. The 2015 Paris Agreement is its most recent notable success. Although the climate negotiations are a state government-led process, the UNFCCC (United Nations Framework Convention on Climate Change) community h

Particles beyond the Standard Model (SM) can generically have lifetimes that are long compared to SM particles at the weak scale. When produced at experiments such as the Large Hadron Collider (LHC) at CERN, these long-lived particles (LLPs) can decay far from the interaction vertex of the primary proton–proton collision. Such LLP signatures are distinct from those of promptly decaying particles t

Guava fruit is rich in phenolic compounds (PCs), whose metabolic fate has not been explored. Non-digestible carbohydrates and PCs in whole guava (WG) and seedless guava (SG) were submitted to an in vitro colonic fermentation, followed by evaluation of the anti-proliferative activity of the fermentation extracts in HT-29 cancer cell lines. The main PCs in both samples were (+)-gallocatechin and gal

We demonstrate a procedure for obtaining a H-intercalated graphene layer that is found to be chemically decoupled from the underlying metal substrate. Using high-resolution x-ray photoelectron spectroscopy and scanning tunneling microscopy techniques, we reveal that the hydrogen intercalated graphene is p-doped by about 0.28 eV, but also identify structures of interfacial hydrogen. Furthermore, we

This work explored the use of pregelatinised amaranth flour (PAF) as an oil substitute in the preparation of amaranth cakes. Amaranth flour was extruded to achieve approximately 50% gelatinisation, ground and sieved. The PAF was used to replace the oil in the cake preparation at levels 33, 66% and 100%. FTIR analysis of the cake formulations showed that PAF modified the molecular organisation of s

Boreal forests have a large impact on the global greenhouse gas balance and their soils constitute an important carbon (C) reservoir. Mature boreal forests are typically a net CO2 sink, but there are also examples of boreal forests that are persistent CO2 sources. The reasons remain often unknown, presumably due to a lack of understanding of how biotic and abiotic drivers interact to determine the

The elliptic flow, v2, of muons from heavy-flavour hadron decays at forward rapidity (2.5