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In this perspective, we ask the question whether the apparently lower solubility of specific proteins in amyloid disease is a cause or consequence of the protein deposition seen in such diseases. We focus on Alzheimer's disease and start by reviewing the experimental evidence of disease-associated reduction in the measured concentration of amyloid β peptide, Aβ42, in cerebrospinal fluid. We propos
Ancient environmental DNA is increasingly vital for reconstructing past ecosystems, particularly when paleontological and archaeological tissue remains are absent. Detecting ancient plant and animal DNA in environmental samples relies on using extensive eukaryotic reference genome databases for profiling metagenomics data. However, many eukaryotic genomes contain regions with high sequence similar
Non-technical summary. As glaciers shrink and disappear, the benefits they provide to people may also be fading. This makes it more important than ever to look closely at how melting glaciers affect both the environment and the communities that depend on them. To truly understand what is being lost- or even gained- we need to study glaciers from many angles. This includes looking at the science of
Surface tension is crucial for nanowire vapor liquid solid (VLS) growth models and simulations of growth under external stimuli. A promising method involving imaging droplet deformation under an external electric field has previously been used to report the surface tension of the AuSi eutectic catalyst on Si-nanowires. However, simplified assumptions in this approach led to a significantly lower v
The extensive genetic diversity of HIV-1 represents a major challenge to public health interventions, treatment, and successful vaccine design. This challenge is particularly pronounced in the Middle East and North Africa (MENA) region, where limited data among other barriers preclude the accurate characterization of HIV-1 genetic diversity. The objective of this review was to analyze studies cond
Objective To investigate the effect of Body Mass Index (BMI) on long-term radiographic damage in an inception rheumatoid arthritis (RA) cohort. Methods The study population, n=1813, originated from the observational Better AntiRheumatic FarmacoTherapy cohort. X-rays of hands and feet at inclusion, 1, 2, 5, 8 and 15 years were quantified for erosion score (ES), joint space narrowing (JSN) and the s
Introduction: Dislocation is a major complication of total hip arthroplasty (THA) for femoral neck fractures (FNFs). Dual mobility cups (DMCs) are in clinical practice for patients at risk of dislocation in primary-and revision arthroplasty. This study investigated whether changing routines from conventional THA (cTHA) to DMC for fracture patients at our orthopaedic unit resulted in a reduced disl
Stage- and lineage-specific gene expression patterns are controlled by a complex interplay between transcription factors, the epigenetic landscape, and the three-dimensional (3D) structure of the DNA. The 3D structure allows for the formation of DNA loops that juxtaposition distal regulatory elements to the promoters, allowing for tight control of gene expression. Developing a tool to facilitate t
The hydrogenation of CO2 into methanol by a nickel pincer catalyst has been studied in both aqueous and solid–gas phases. Hydrogenation occurs at the moderate temperatures of 60–95 °C. The solid–gas phase reaction is found to be more efficient than the aqueous reaction. At 95 °C and 1 MPa of H2/CO2 (3:1), 18 μmol of methanol is generated in the optimized solid–gas phase reaction versus 10 μmol in
The presence of pharmaceuticals, especially antibiotics, in aquatic environments can significantly contribute to the rise of antibiotic resistance, presenting a critical global public health challenge. This study investigates the presence of four selected antibiotics and an antiretroviral drug (nevirapine) in the Vaal River in South Africa. Grab samples collected at nine sampling sites across four
Standard ZYMO DNA/RNA miniprep extraction protocol written in a user friendly way to reduce in-process-decisions and process time
Modified ZYMO DNA/RNA miniprep extraction protocol written in a user friendly way to reduce in-process-decisions and process time. Sample type is organic soil, peat, from a degraded rich fenThis protocol includes two modifications to tackle clogged filters. Samples were centrifuged for 45 seconds instead of 30 seconds in first pass through filters as 100 ul to 200 ul sample remained trapped above
Modified ZYMO DNA/RNA miniprep extraction protocol written in a user friendly way to reduce in-process-decisions and process time. Sample type is organic soil, peat, from a degraded rich fenThis protocol includes modifications to tackle clogged filters. Samples were centrifuged for 45 seconds instead of 30 seconds in first pass through filters as 100 ul to 200 ul sample remained trapped above filt
Aberrant protein aggregation into amyloid fibrils is often catalyzed by interfaces. Therefore, it is important to characterize the surface activity of chaperone proteins having the ability to suppress amyloid formation. The air–water interface is of large practical significance in experimental setups used to study aggregation kinetics in vitro, but in addition, the binding of chaperones to hydroph
Breakthroughs in battery research are imperative to provide society with batteries that are safe and sustainable, have a high energy density, and have a long cycle life at low cost. Recent advances in research methodologies, the emergence of new market opportunities, and strategic funding schemes have allowed not only large, but also small companies, universities, and public research organizations
Precisely determining the oxidation states of metal cations within variable-valence transition metal oxides remains a significant challenge, yet it is crucial for understanding and predicting the properties of these technologically important materials. Iron oxides, in particular, exhibit a remarkable diversity of electronic structures due to the variable valence states of iron (Fe 2+ and Fe 3+). A
UNLABELLED: The primary objective of this study was to investigate whether ligand-receptor interactions (LRIs) between IGHG and FCGR gene products are associated with progression to type 1 diabetes (T1D). Using two completed clinical trials (DPT-1 and TN07), we applied next-generation targeted sequencing to genotype IGHG and FCGR genes in a cohort of 1,214 individuals and assessed LRI associations
Detta arbete undersöker tillväxteffekten av andelen förnybar elproduktion av den totala nationella elmixen med paneldata från 49 afrikanska länder 1996-2020, i Fixed Effects-regressioner. Förnybar energi framhålls ofta som en nyckelfaktor för hållbar utveckling, samtidigt som sambandet mellan förnybar energi och ekonomisk tillväxt är omdiskuterat i tidigare forskning. Resultaten i denna undersökni
This study investigates the effects of climate policy uncertainty (CPU) shocks on metal spot prices from 1990 to 2025 using impulse response analysis within a Vector Auto-Regressive (VAR) framework. The results indicate that price responses are time-varying and heterogeneous across metals. Overall, CPU shocks are found to have contemporaneous negative effects with short-term persistence. Although
