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Background Prothrombin is a vitamin K-dependent glycoprotein synthesized in the liver and circulating in blood as an inactive zymogen. The corresponding activated thrombin enzyme is a central player in hemostasis and thrombosis. Still, little is known about the individual variation over time of the prothrombin concentration in plasma in the general population. Objectives This study aimed to establ
Objective: Investigate the role of metabolic syndrome and obesity in incident osteoarthritis (OA). Methods: Prospective cohort study with up to 11 years follow-up. From a general population cohort of 28,786 individuals from Sweden aged 45 to 75, we selected individuals without OA diagnosis and without joint pain during the year prior to the baseline. Metabolic syndrome was defined at baseline by t
The use of remote sensing and reanalysis weather data has not been adequately acknowledged for large-scale built environment applications, primarily regarding engineering analyses that traditionally rely on computationally expensive numerical models. This study employs a parsimonious data-driven approach concerning service life assessment of rain-exposed wooden components, enabling mapping and ass
Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic stroma, which plays a crucial role in tumor biology and treatment resistance. While the stromal compartment is a defining histopathological feature of PDAC, its prognostic significance remains incompletely understood. This study aimed to quantify the stromal content in PDAC using digital pathology and
The bladder trigone is a distinct anatomical and functional subregion of the urinary bladder, defined by its triangular configuration between the ureteral orifices and the internal urethral orifice. Although traditionally less studied compared to the bladder dome and detrusor body, recent morphological, molecular, and transcriptomic analyses reveal that the trigone is highly specialized. Understan
Understanding greenhouse gas fluxes in semi-arid ecosystems is critical for improving our understanding of biogeochemical cycles, particularly in underrepresented regions like the African Sahel. In these landscapes, greenhouse gas exchange arises from ground, trees, and water ponds, and is further shaped by environmental conditions and grazing. The carbon dioxide, methane, and nitrous oxide fluxes
Leigh syndrome is a fatal pediatric neurodegenerative disease caused by mitochondrial dysfunction, which can be modeled in the Ndufs4 KO mouse with mitochondrial respiratory chain complex I (CI) deficiency. This study explores NV354, a prodrug of succinate with enhanced oral bioavailability and brain uptake, as a potential therapy to counteract this devastating condition. NV354 modulated whole-bod
In recent years, international non-governmental organisations (INGOs) in India have operated under intensifying regulatory constraints that have profoundly reshaped the civic terrain. Legal instruments such as the Foreign Contribution Regulation Act (FCRA) do not simply restrict INGOs’ activities; they recalibrate the conditions under which civil society can exist, act, and speak. This article
Imagination shapes politics. It determines not only the futures we envision but the very forms of collective life we deem possible. Yet under neoliberal governance, imagination itself is under erasure; not merely the imagining of radical futures, but the conceptual boundaries of what can be imagined. Civil society, long imagined as a space of participation and solidarity beyond state and market, i
This study presents a comprehensive investigation of the structural, microstructural, electrical, magnetic, and magnetoelectric properties of low-level substitution of Co3 + for Fe3+ ions in the perovskite B-site of BiFeO3 (BiFe1−xCoxO3, x = 0.01, 0.015 and 0.02). X-ray diffraction combined with Rietveld refinement confirms the retention of the rhombohedral R3c structure across all compositions, w
Intracellular deposits of neurofibrillary tau tangles and extracellular Aβ plaques are closely associated with Alzheimer’s disease. The mapping of thermodynamic parameters, including solubility limits, indicates when a protein forms amyloid fibrils or remains in solution. This reveals the direction of change of the system and may help in understanding drift and steady states in living systems. Her
This study provides an in-depth analysis of the impact of a multimodal journey-planning app on users of informal public transport systems in Cochabamba, Bolivia. We analyze survey data (N=648) collected through the Trufi Association NGO's digital travel app on changes in mobility behavior, satisfaction, and everyday life improvements. Participants report more frequent use of informal transport (49
Black carbon (BC) is an air pollutant of emerging concern, and further evidence is needed to understand its health effects. This study investigates the association between gestational BC exposure and birth outcomes, and whether these effects are independent of particulate matter with an aerodynamic diameter of ≤ 2.5 μm (PM2.5) exposure. We used data from the population-based birth cohort, Maternal
Groundwater-dependent vegetation (GDV) plays a vital role in maintaining biodiversity and ecosystem services in the Mediterranean biome but is increasingly threatened by climate and land use change. Large-scale GDV mapping in arid regions is critical for effective conservation and water resource management but remains challenging due to limited ground-truth data and the lack of high-resolution rem
Background: Prenatal exposure to ambient air pollution has been linked to autism spectrum disorder (ASD), but evidence from low-exposure settings such as Denmark remains limited.Objective: We aimed to examine the association between prenatal exposure to particulate matter with a diameter of ≤2.5 µm (PM2.5), black carbon (BC), and nitrogen dioxide (NO2) and ASD in children, and to identify the most
This study examines the sensitivity of mean, high and low streamflows (i.e., Q elasticity) to changes in precipitation (P) and potential evapotranspiration (PET) across South America. The response to P was further assessed by intensifying its seasonal and daily distribution, specifically by increasing (decreasing) P during wet (dry) periods and high (low) events, while maintaining the annual P vol
The European eel (Anguilla anguilla) faces significant challenges during its migratory lifecycle due to anthropogenic habitat fragmentation. Fish passage solutions, such as eel ramps, aim to mitigate such barriers, but their effectiveness varies and may impose selective pressures on eel phenotypes. This study evaluates the impact of ramp design and water flow on the climbing success of juvenile ee
Litter decomposition is a source of gaseous products, including volatile organic compounds (VOCs) to the atmosphere. The quantity and the chemical composition of the VOC blends released from litter vary between plant species and depend on environmental factors and litter microbial communities. Here, we assessed VOC release from decomposing litter in a 3-year incubation conducted in a climate manip
