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The amyloid cascade hypothesis has strongly impacted the Alzheimer's disease research agenda and clinical trial designs over the past decades, but precisely how amyloid-β pathology initiates the aggregation of neocortical tau remains unclear. We cannot exclude the possibility of a shared upstream process driving both amyloid-β and tau in an independent manner instead of there being a causal relati
Air concentrations of polycyclic aromatic compounds (PACs) were measured in a Norway spruce (Picea abies) stand at four different distances from a major traffic route near Gothenburg, Sweden, during summer and winter 2019, using passive samplers. In total, the concentrations of 32 polycyclic aromatic hydrocarbons (PAHs) and six dibenzothiophenes (DBTs) and NO2 were analysed. PAC air concentrations
Climate change and eutrophication are two environmental threats that can alter the structure of freshwater ecosystems and their service functions, but we know little about how ecosystem structure and function will evolve in future scenarios of climate warming. Therefore, we created different experimental climate scenarios, including present-day conditions, a 3.0 °C increase in mean temperature, an
Stock and bond are the two most crucial assets for portfolio allocation and risk management. This study proposes generalized autoregressive score mixed frequency data sampling (GAS MIDAS) copula models to analyze the dynamic dependence between stock returns and bond returns. A GAS MIDAS copula decomposes their relationship into a short-term dependence and a long-term dependence. While the long-ter
The tropical Pacific Ocean plays a significant role in climate change, and the El Niño-Southern Oscillation (ENSO) is considered to be closely related to extreme climate phenomenon worldwide. However, the evolution of the ENSO-like patterns in the tropical Pacific during the Pleistocene glacial cycles remains controversial. In this study, we present geochemical indices and a transient model simula
Background: The identification of biomarkers that reflect worse progression of nonmotor symptoms (NMS) in Parkinson's disease (PD) is currently an unmet need. The main aim of this study was to investigate whether cerebrospinal fluid (CSF) and serum neurofilament light (NfL), measured at baseline or longitudinally, can be used to predict the progression of NMS in patients with PD. Methods: Baseline
Objective: To investigate how a behavioral health, artificial intelligence (AI)-powered, digital self-management tool affects the daily functions in adults with chronic back and neck pain. Design: Eligible subjects were enrolled in a 12-week prospective, multicenter, single-arm, open-label study and instructed to use the digital coach daily. Primary outcome was a change in Patient-Reported Outcome
New Zealand's largest city, Auckland, is situated within the basaltic Auckland Volcanic Field (AVF). Therefore, understanding the eruption history of the local volcanoes in the field is of great importance in order to assess future hazards that they may pose. Rangitoto is the youngest and largest volcano in the AVF, although the timing of the first eruption and the duration of the volcanic activit
Deep decarbonisation of extractive and foundational industries will involve widespread social and economic change. Research on previous industrial restructuring has demonstrated that resultant changes will be geographically uneven, especially without countervailing state intervention. Such change has been shown to matter for both the nature and location of work in those industries as well as for t
The positive effects of nature on people's mental health are not only relevant for boosting their lifestyles, but could also play a role in the treatment of mental illness. To this end, the following systematic review investigates whether ecotherapy can achieve similar success as conventional cognitive-behavioral psychotherapy with regard to the treatment of depression and anxiety disorders, and w
About the book:Theatre Institutions in Crisis examines how theatre in Europe is beset by a crisis on an institutional level and the pressing need for robust research into the complex configuration of factors at work that are leading to significant shifts in the way theatre is understood, organised, delivered, and received.Balme and Fisher bring together scholars from different disciplines and coun
About the book:"The Routledge Companion to Theatre and Politics is a volume of critical essays, provocations, and interventions on the most important questions faced by today's writers, critics, audiences, theatre and performance makers. Featuring texts written by scholars and artists who are diversely situated (geographically, culturally, politically, and institutionally), its multiple perspectiv
The Publication “Modeling Public Space(s) in Culture” is a continuation to the Conference Modelling Public Space(s) in Culture organised in Skopje in October 2017. The Conference aimed to offer a diverse thematic overview on “public space” as a physical location creating social ties and “public sphere” that contributes to the formation of public discourse. The publication explores the ideas brough
Invisible Committee, ‘the name given to a collective voice bent on denouncing contemporary cynicism and reality’ (described by one of the members of the anonymous group), published a text in 2007 that hypothesised the ‘imminent collapse of capitalist culture’ that would arise from new waves of social contestation. Under the title The Coming Insurrection the text (denounced as a manual for terroris
About the book:Fourteen scholars who work on campus or in the theater address this issue of what it means to play offstage. With their individual definition of what “offstage” could mean, the results were, predictably, varied. They employed a variety of critical approaches to the question of what happens when the play moves into the audience or beyond the physical playhouse itself? What are the so
Published within the Paletten project: Editorial meeting – A Gathering Towards a Critique of the Contemporary.https://paletten.net/projekt/test-projekt
