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Judah Knows: An Assumption of Theatre

This thesis is a theatrical analysis of Gen 42—44, employing delimitation criticism, poetical analysis and dramaturgical analysis to explore its research questions. The first of these questions is what perspectives on the text come to the fore when it is studied under an assumption of theatre—as if it always was theatre. The second question is whether such a study provides any tenable arguments th

The Resonance of Past-themed Consumption and Marketing

In this thesis, I explore and conceptualise how resonance can be market-mediated. To do this, I unravel the theoretical context of past-themed consumption and marketing. My exploration is based on five standalone papers that all investigate past-themed consumption and marketing. Two of these papers are empirical and employ the context of the Danish vintage cycling community. Three papers are conce

The Impact of Child Disability on Parental Outcomes : Evidence From Sweden

Parents of children with disabilities may face higher labor-market penalties given the extra care and support required. Using Swedish administrative data, we focus on first-born children with Cerebral Palsy (CP) to estimate impacts on parental labor-market outcomes. We apply an event study approach to identify effects up to 10 years after the birth of the child. Our results show that employment an

Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers : a longitudinal cohort study

BACKGROUND: Plasma biomarkers associated with Alzheimer's disease could improve prognostic assessment for people with Down syndrome in both clinical practice and research settings. We aimed to identify the plasma biomarkers that most accurately predict longitudinal changes in Alzheimer's disease-related pathology and cognitive functioning in individuals with Down syndrome.METHODS: This longitudina

Mitochondrial proteome landscape unveils key insights into melanoma severity and treatment strategies

BACKGROUND: Melanoma, the deadliest form of skin cancer, exhibits resistance to conventional therapies, particularly in advanced and metastatic stages. Mitochondrial pathways, including oxidative phosphorylation and mitochondrial translation, have emerged as critical drivers of melanoma progression and therapy resistance. This study investigates the mitochondrial proteome in melanoma to uncover no

Adolescent Mental Health : Impact of Introducing Earlier Compulsory School Grades

We examine how the earlier introduction of compulsory school grades affects the likelihood of receiving a mental disorder diagnosis among Swedish adolescents. We exploit a school reform that shifted the introduction of grades from grade 8 to grade 6, resulting in first exposure to grading at different ages between cohorts. Our results show that girls exposed to earlier grading are more likely to b

Apathy and affective symptoms associated with elevated plasma neurofilament light but not p-tau181 in Alzheimer's disease

INTRODUCTION: Apathy and affective neuropsychiatric symptoms (NPS) are prevalent in Alzheimer's disease (AD), yet their neurobiological cause is still unclear. We examined associations between plasma neurofilament light chain (NfL) and tau pathology (p-tau181) with apathy and affective symptoms in mild cognitive impairment (MCI) and AD dementia. METHODS: This longitudinal study analyzed data from

Using Compression Stockings to Prevent Recurrence of Vasovagal Syncope : A Randomized Sham-Controlled Trial

Background: Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear. Objectives: This study sought to compare the effectiveness of lower extremity compression with thigh-high ECS vs sham stockings for the prevention of VVS recurr

The heterogeneity of type 1 diabetes : implications for pathogenesis, prevention, and treatment - 2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum

This article summarises the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organised by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors contributing to the development and progression of type 1 diabetes and outlined specific, high-priority research questions. Knowledge gaps were identified and, nota