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BACKGROUND: Angiotensin II (Ang II) has been implicated in the development of cardiac fibrosis. The aims of the present study were to examine expression and activity of ACE and of angiotensin receptors in human cardiac fibroblasts cultured from dilated cardiomyopathic and ischemic hearts. The effects of Ang II on fibroblasts were also investigated. METHODS AND RESULTS: Human cardiac fibroblasts we
Knowledge of how the content of low molecular weight carbohydrates (LMWC), including the raffinose family oligosaccharides (RFO; raffinose, stachyose and verbascose), changes in unripe peas (Pisum sativum) around harvest time, is today limited. An early and a late maturing cultivar of peas were harvested with 24 h of each other on seven different occasions, of which three were chosen for this stud
This thesis consists of five papers (Paper A-E) on statistical modeling of diffusion processes. Two papers (Paper A & D) consider Maximum Likelihood estimators for non-linear diffusion processes. An offline Maximum Likelihood estimator is derived in Paper A, and it is shown that this estimator is computationally more efficient than other Maximum Likelihood estimators. The offline algorithm is
The azimuthal distributions of photons and charged particles with respect to the event plane are investigated as a function of centrality in Pb-208 + Pb-208 collisions at 158 (.) A GeV/c in the WA98 experiment at the CERN SPS. The anisotropy of the azimuthal distributions is characterized using a Fourier analysis. For both the photon and charged particle distributions the first two Fourier coeffic
Recombinant cystatin C producing clones were isolated from a human placenta λgt11 cDNA library. The cDNA insert of one of the clones, containing 777 base pairs, encodes the complete mature cystatin C (120 amino acids) and a hydrophobic leader sequence of 26 amino acids, indicating an extracellular function of the inhibitor. The deduced protein sequence confirms the protein sequence of cystatin C i
Popular Abstract in Swedish Våra vita blodceller bildas i benmärgen och när de mognat färdigt hamnar de i blodcirkulationen. Det finns olika typer av vita blodceller och varje typ har sin egen funktion. En speciell typ av vit blodcell, nämligen den myeloida vita blodcellen (neutrofilen), spelar en mycket viktig roll i kroppens första försvar mot invaderande bakterier. När bakterier kommer in i kroIn myelopoiesis, neutrophils and monocytes/macrophages are formed from a common myeloid precursor cell in the bone marow. During maturation of neutrophils, cytoplasmic granules are formed in the cells and the content of these granules is critical for the function of neutrophils in the first line of defense against invading microorganisms. The Bactericidal/Permeability-Increasing protein (BPI) is s
Three-dimensional imaging of fuel tracer planar laser-induced fluorescence in a homogeneous charge compression ignition (HCCI) engine is presented. A high-speed multiple Nd:YAG laser and detection system, in combination, with a scanning mirror, are used to collect eight images, with an equidistant separation of 0.5 mm. Three-dimensional isoconcentration surfaces calculated from the data are visual
Clinical research, when children involved, may cause difficult ethical problems for both caregivers and parents. Informed consent has to be obtained from the parents and from the child depending on age and maturity. The concept of informed consent is complicated and depending on the ability of communication between the professionals and the parents. The aim of the study was to illuminate parents l
Innovations are necessary for growth and competitiveness, but few are taking place in the food industry. Clusters and networks in regions/countries are seen as one way of increasing the chances to compete, based on Porter's theories in 1990. Before that some articles existed about agglomeration, clustering of industries etc. but not many examples in the food industry seem to have been studied. Thi
A gene coding for the multi-copper phenol oxidase laccase has been isolated from the white-rot basidiomycete Trametes oersicolor. The gene, which is preceded by a TATA box and a pyrimidine-rich region, is predicted to contain ten introns. The mature translation product, preceded by a 22-residue signal peptide, should consist of 498 residues. Comparisons with Edman degradation data of peptides from
An introduction to and edition of a previously unpublished legend for the Canonization Day of the Swedish national saint, Birgitta Birgersdotter. The legend exists today in one single manuscript, Uppsala University Library, ms. C 24, written in the second half of the fifteenth century. The legend has three main parts: the first describes the holy life of St Birgitta in the form of two "sermons"; t
Cross-linked agarose particles (Sepharose CL-6B) and baker's yeast cells were found to adhere to siliceous supports end-grafted with boronate-containing copolymers (BCCs) of N,N-dimethylacrylamide at pH >= 7.5, due to boronate interactions with surface carbohydrates of the particles and the cells. These interactions were registered both on macroscopic and on molecular levels: the BCCs spontaneousl
Previous studies demonstrated that neuropeptides are transported with fast axonal transport. Considerable amounts (30-40%) of anterogradely transported peptides accumulated distal to a crush, apparently recycling to the cell bodies. In the present study, we used primary and compartmented cultures of sympathetic cervical ganglia (SCG) to address questions on the origin of the recycling peptides. In
Aims and objective. To evaluate patient- reported health outcomes of a multidisciplinary group educational programme for people with Parkinson's disease ( PD), delivered as part of routine clinical practice. Background. Studies suggest that educational programmes for people with PD have potential to improve patients' perceived health and well- being. However, controlled trials of multidisciplinary
The aim of the study was to evaluate, from a technical and economic standpoint, the enzymatic processes involved in the production of fuel ethanol from softwood. Two base case configurations, one based on simultaneous saccharification and fermentation (SSF) and one based on separate hydrolysis and fermentation (SHF), were evaluated and compared. The process conditions selected were based mainly on
