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Longitudinal data are presented on a boy between the ages ofthree and eight. At age three he received a diagnosis oflanguage impairment and at age six a diagnosis of high-functioning autism. Results are presented from extensive assessments at four points in time, including interviews with his mother and teachers. The results indicate that the boy s core problem was poor language comprehension, esp
Multinuclear NMR has been used to investigate the structure and mobility of a series of polymer gel electrolytes. The co-polymers used as matrixes in the gels have acrylate backbones and side chains of ethylene oxide, where the length of the side chains has been varied, while the ratio of acrylate to ethylene oxide has been kept constant. The electrolyte is a mixture of lithium perchlorate and two
OBJECTIVE: To investigate gene expressions for neurohypophyseal and ovarian hormones as well as their receptors in the endometrium of women with primary dysmenorrhoea and healthy subjects at ovulation. STUDY DESIGN: A group of eight women with moderate to severe dysmenorrhoea and eight healthy subjects were compared in parallel between 18 and 35 years of age, regularly menstruating, non-overweight
High-resolution correlations, partly with a precision better than 10 ka, are achieved between late Ludfordian sequences on Gotland, Sweden (on Baltica), and a section (COG) through the Coral Gardens Formation along the Broken River, northeastern Australia (on Gondwana), despite these sections having been on different palaeocontinents facing different oceans. The interval is characterised by rapid,
Cellular metabolism of glucose is required for stimulation of insulin secretion from pancreatic beta cells, but the precise metabolic coupling factors involved in this process are not known. In an effort to better understand mechanisms of fuel-mediated insulin secretion, we have adapted 13C NMR and isotopomer methods to measure influx of metabolic fuels into the tricarboxylic acid (TCA) cycle in i
There are currently strong incentives for increased use of renewable fuels in the transport sector worldwide. However, some bioethanol and biodiesel production routes have limitations with regard to resource efficiency and reduction of greenhouse gases. More efficient biofuel systems are those based on lignocelluloses and novel conversion technologies. A complementary strategy to these is to incre
Recent work on the expression of retinal transcription factors and other molecular cues delivers interesting but partly contradictory information on the early phases of eye evolution.
We used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human alpha -synuclein in the substantia nigra of adult marmosets. The alpha -synuclein protein was expressed in 90-95% of all nigral dopamine neurons and distributed by anterograde transport throughout their axonal and dendritic projections. The transduced neurons developed severe neuronal pathology, inc
When the wavelength is much larger than the typical scale of the microstructure in a material, it is possible to define effective or homogenized material coefficients. The classical way of determination of the homogenized coefficients consists of solving an elliptic problem in a unit cell. This method and the Floquet-Bloch method, where an eigenvalue problem is solved, are numerically compared wit
This article describes and evaluates algorithms and their hardware architectures for binary morphological erosion and dilation. In particular, a fast stall-free low-complexity architecture is proposed that takes advantage of the morphological duality principle and structuring element (SE) decomposition. The design is intended to be used as a hardware accelerator in real-time embedded processing ap
A decreased fermentation rate due to inhibition is a significant problem for economic conversion of acid-pretreated lignocellulose hydrolysates to ethanol, since the inhibition gives rise to a requirement for separate detoxification steps. Together with acetic acid, the sugar degradation products furfural and 5-hydroxymethyl furfural are the inhibiting compounds found at the highest concentrations
Intake of fruits and vegetables is thought to protect against the development of lung cancer. However, some recent cohort and case-control studies have shown no protective effect. We have assessed the relation between fruit and vegetable intake and lung cancer incidence in the large prospective investigation on diet and cancer, the European Prospective Investigation Into Cancer and Nutrition (EPIC
A bacterial thermostable citrate synthase has been analyzed to investigate the structural basis of its thermostability, and to compare such features with those previously identified in archaeal citrate synthases. The gene encoding the citrate synthase from Thermus aquaticus was identified from a gene library by screening with a PCR fragment amplified from genomic DNA using a primer based on the de
In this paper, we introduce a first order accurate resonance model based on a second order Pade approximation of the reflection coefficient of a narrowband antenna. The resonance model is characterized by its Q factor, given by the frequency derivative of the reflection coefficient. The Bode-Fano matching theory is used to determine the bandwidth of the resonance model and it is shown that it also
Clinicians currently use simple cut-points, such as serum prostate-specific antigen (PSA) >= 4 ng/ml, to decide whether to recommend further work-up for prostate cancer (PCa). As an alternative strategy, we evaluated multivariable models giving probabilities of a PCa diagnosis based on PSA and several circulating novel biomarkers. We measured total PSA, free PSA (fPSA), fPSA subfractions (single-c
This paper presents a computer-based decision support system for automated interpretation of diagnostic heart images (called WeAidU), which is made available via the Internet. The system is based on image processing techniques, artificial neural networks (ANNs) and large well-validated medical databases. We present results using artificial neural networks, and compare with two other classification
AlSb-V-W-oxide catalysts were prepared and used for propane ammoxidation to give acrylonitrile. The preparations were characterized, both as freshly prepared and after use in propane ammoxidation, using XRD, XPS, Raman spectroscopy, and transmission electron microscopy together with electron diffraction and X-ray microanalysis. Activity tests of the freshly prepared samples reveal a remarkable act
