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The high prevalence (>5%) of autoimmune hypothyroidism (AIHT) provides a unique opportunity to dissect genetic contributions to systemic and organ-specific autoimmunity. Here we performed a genome-wide association meta-analysis of 81,718 AIHT cases in FinnGen and the UK Biobank, identifying 418 independent signals (P < 5 × 10−8). At 48 of these loci, a protein-coding variant is, or is highly corre
Urban meteorology, the study of atmospheric phenomena in urban areas, is vital for understanding the dynamic interactions between rapid urbanization and environmental changes. Over the past two decades (2004–2024), urban heat islands (UHIs), extreme rainfall, pollution, and temperature anomalies have intensified, adversely affecting human health, infrastructure, and ecosystems worldwide. The prese
BackgroundImmune-related hepatitis (ir-hepatitis) ranks among the most frequent adverse events of immune checkpoint inhibitors (ICIs). Limited knowledge exists regarding the incidence, characteristics, and treatment of patients having an inadequate response to initial therapy with steroids. Characterizing ir-hepatitis phenotypes and treatment responses can provide valuable insights for guiding tre
Methacrylated Pluronic triblock copolymers are widely used as photo-cross-linkable hydrogels, yet the effect of terminal methacrylation on self-assembly and thermoreversible gelation prior to cross-linking remains poorly understood. Here, we systematically investigate how the degree of methacrylation influences micellization, micelle packing, and gelation in Pluronic F127 using differential scanni
Technological advances in computed tomography (CT) have highlighted limitations of traditional dose descriptors such as computed tomography dose indexvol and dose-length product, particularly for wide-beam and modulated acquisitions. This study investigates a CT-specific, operational air kerma–area product derived from time-resolved measurements using small solid-state dosemeters mounted at the ga
Min avhandling är en undersökning av civilsamhälleliga aktörers vardagliga erfarenheter av hur väpnad konflikt, utvinningsindustri och motstånd har format det colombianska Andinoamazonia under landets pågående fredsbyggande process. Trots ett tjugotal fredsavtal och undertecknandet av ett övergripande avtal 2016 har Colombias långvariga väpnade konflikt inte upphört. Det colombianska AndinoamazoniMy thesis is an inquiry into the daily experiences of civil society actors in relation to how armed conflict, extractivism, and resistance shaped the Colombian Andinoamazonia during the country’s current peacebuilding cycle. Despite two dozen peace agreements, and the signing of a comprehensive agreement in 2016, Colombia’s protracted armed conflict did not end. The Colombian Andinoamazonia, a bio
Several scholarly works have identified the weakness of mainstream social science and the humanities to theorize racism. The sociology of absence grasps the systematic exclusion of specific experiences and specific voices within social theory. We are inspired by these contributions in our exploration of the role and the location of the category of residents racialized as not belonging to the Swedi
The fall of 2022, with the election success of a coalition of right wing and ethnoracist parties, marks the transition from a racialized to a racist state in Sweden. We analyse the discourses of three welfare projects in Swedish racial capitalism - Keynesian, Neoliberal, and ethnoracist - in relation to safety/security.Methodologically, we use CDA analysing elite institutional texts (party documen
Chemical communication is the oldest and most widespread form of signalling among and within organisms. Among the many compounds involved in such communication, pyrazines – nitrogen-containing heterocyclic molecules – are especially intriguing due to their widespread occurrence across the tree of life, from bacteria and fungi to insects and mammals. In this review, we focus on the role of pyrazine
BACKGROUND: Familial aggregation of stroke is well-documented, yet few studies have examined associations between stroke subtypes-particularly early-onset cryptogenic ischaemic stroke (eCIS)-and broader family history (FH) of cardiovascular disease. Such associations may provide insights into underlying etiologic mechanisms. METHODS: In this multicentre case-control study, we included eCIS patient
We address discrete-time consensus on the Euclidean unit sphere. For this purpose we consider a distributed algorithm comprising the iterative projection of a conical combination of neighboring states. Neighborhoods are represented by a strongly connected directed graph, and the conical combinations are represented by a (non-negative) weight matrix with a zero structure corresponding to the graph.
Denna avhandling undersöker hur aktörer i Stilla havet producerade och spred oppositionell kunskap om kärnvapentester från 1950-talet till början av 2000-talet, med Franska Polynesien i fokus. För att analysera detta lanseras begreppet vittnesaktivism som övergripande står för organiserade praktiker av vittnesmål, dokumentinsamling, arkivering och transnationell spridning, genom vilka aktörer utmaThis dissertation examines how actors in the Pacific produced, mobilized, and circulated oppositional knowledge about nuclear weapons testing from the 1950s to the early 2000s, with French Polynesia as its primary focus. At its core is witness activism: coordinated practices of testimony, document retrieval and annotation, archiving, publication, and transnational circulation through which activis
INTRODUCTION: People with longstanding hip and groin pain (LHGP) are often referred to orthopaedic care. Physical therapist-led interventions are recommended in consensus statements as the first line of treatment, but it is unknown if structured interventions are more effective than usual care. The aim of this trial is to evaluate the effectiveness of a structured physical therapist-led treatment
Relaxed eddy accumulation (REA) measurements for 14CO2 enable the estimation of fossil fuel (ff) CO2 fluxes in urban areas. This work is based on 252 REA ffCO2 flux measurements conducted on tall towers in the cities of Zurich, Paris, and Munich. The ffCO2 fluxes were compared to net eddy covariance CO2 fluxes to quantify the role of non-fossil (nf) CO2 fluxes. While the measurements in Zurich and
This thesis consists of three essays in dynamic panel data econometrics. It studies the estimation of persistent dynamic relationships in panel models with unobserved heterogeneity and predetermined regressors, combining methodological contributions with an application in growth empirics.The first paper analyzes structural breaks in persistence in a dynamic panel first-order autoregressive model w
This instruction is for the bioFDM printing process developed at bioDigital matter lab. It was developed for the production of Protomycokion, a 2 m tall experimental column. The recipe uses a wood-decomposing brown-rot fungus, Gloeophyllum, and results in lightweight objects with a hard, brownish and variable surface. The resulting surface is hydrophobic yet allows water vapor permeability.
