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Periodontitis is a complex chronic inflammatory noncommunicable disease, initiated by the development of a dysbiotic microbial plaque biofilm below the gingival margin. Whilst the pathogenic biofilm is a “necessary cause” of periodontitis, it is insufficient on its own to cause the disease, and a destructive immune-inflammatory response is a key to the translation of risk to destructive events. Ot
Solar photovoltaics (PV) has experienced tremendous market growth and has large potential in the urgently needed transition towards a low-carbon energy system. The continued growth of the sector will, however, evoke new sustainability challenges with regard to efficient material use as well as end-of life management of PV products. The aim of this paper is to provide an overview of potential Circu
The aim of the present paper is to investigate the level of airborne wear particles released during the dyno-bench tests with the brake pads consisting of alkali-activated slag as an abrasive. Airborne wear particles are generated with a full-scale dyno-bench adapted for airborne wear particles emission studies. The tested disc brake is equipped with two semi-metallic brake pads and a grey cast ir
The ability of citizens to establish the credibility of information and information sources through critical assessment is often emphasized as essential for the upholding of a democratic society and for people’s health and safety. Drawing on material-discursive conceptualizations, the article asks, how does critical assessment of information and information sources play out as it is folded into a The ability of citizens to establish the credibility of information andinformation sources through critical assessment is oftenemphasized as essential for the upholding of a democraticsociety and for people’s health and safety. Drawing on material-discursive conceptualizations, the article asks, how does criticalassessment of information and information sources play out as itis folded into a netwo
The issuing of Opinion 2/13 on the European Union’s (EU’s) accession to the European Convention on Human Rights by the Court of Justice of the EU (CJEU), followed by Case C- 284/16 Achmea and Opinion 1/17 on the compatibility with EU law of the Comprehensive Economic and Trade Agreement between Canada and the European Union (CETA), brought the concept of the autonomy of the EU legal order to the p
How can anthropologists negotiate access in high-profile, bureaucratic apparatuses, such as a UN human rights monitoring mechanism – and what can a detailed account of these negotiations tell us of such apparatuses, their operational dynamics and the processes through which they exert an impact, broadly construed? This article addresses these questions through the notion of tactical subjectivity b
The transformation of chronic lymphocytic leukemia (CLL) to high-grade B-cell lymphoma is known as Richter's Syndrome (RS) and it is a rare event with dismal prognosis. In this study, we conducted whole genome sequencing (WGS) of paired circulating CLL (PB-CLL) and RS biopsies (tissue-RS) from 17 clinical trial (CHOP-O) patients. We found that tissue-RS was enriched for mutations in poor-risk CLL
Rationale: Hypercapnia develops in one third of patients with advanced chronic obstructive pulmonary disease (COPD) and is associated with increased morbidity and mortality. Multiple factors in COPD are thought to contribute to the development of hypercapnia including increased carbon dioxide (CO2) production, increased dead space ventilation, and the complex interactions of deranged respiratory s
In this study, static coefficients of friction for laminated veneer lumber on steel surfaces were determined experimentally. The focus was on the frictional behaviors at different pressure levels, which were studied in combination with other influencing parameters: fiber orientation, moisture content, and surface roughness. Coefficients of friction were obtained as 0.10–0.30 for a smooth steel sur
The forthcoming Laser Interferometer Space Antenna (LISA) will probe the population of coalescing massive black hole (MBH) binaries up to the onset of structure formation. Here, we simulate the galactic-scale pairing of ∼106 M☉ MBHs in a typical, non-clumpy main-sequence galaxy embedded in a cosmological environment at z = 7-6. In order to increase our statistical sample, we adopt a strategy that
Aim: To explore reach and experiences of participants during implementation of health-promoting meetings of seniors in a Swedish municipality context. Subjects and methods: A mixed-methods approach was used, including older people who were recruited consecutively and invited to participate as they applied for health care and/or home help services in the municipality. Inclusion criterion was alloca
Introduction: The aim of this study was to evaluate three occupational therapy interventions, focused on supporting continued engagement in occupation among older people, to determine which intervention was most cost effective, evaluated as the incremental cost/quality adjusted life year gained. Method: The study was based on an exploratory randomized controlled trial. Participants were 77-82 year
Preventing factor VIII (FVIII) inhibitors following replacement therapies with FVIII products in patients with hemophilia A remains an unmet medical need. Better understanding of the early events of evolving FVIII inhibitors is essential for risk identification and the design of novel strategies to prevent inhibitor development. The Hemophilia Inhibitor Previously Untreated Patients (PUPs) Study (
This chapter offers a comprehensive summary of applications of advanced diffusion encoding methods in MRI within a narrowly defined area of in vivo human measurements with imaging read-out and voxel-by-voxel data analysis. The list of methods comprises tensor-valued encoding to investigate cell densities, shapes, and orientations in heterogeneous tissues, time/frequency-dependent encoding for esti
This study investigates the sex steroid hormone profile in younger men with distal radius fracture (DRF) to elucidate if this could explain the low bone density and osteoporosis previously observed. In a case–control study, 73 men with DRF (mean age 38 ± 9 years; range, 20–51) was compared with 194 age-matched, population controls. Performed assays: total testosterone (TT), calculated free testost
The persistent, difficult-to-treat, allergic contact dermatitis from hexavalent chromium in European construction workers has diminished significantly since the legislative measurements that came into force in January 2005. However, sensitization to hexavalent chromium continues to be a problem. Barrier creams have been tried for various allergens with divergent results. Objective The aim of the s
This paper is intended to discuss the optimization of camshaft efficiency; using the rolling bearing instead of the sliding bearing within the internal combustion engines. The advantages and disadvantages of employing this new method will be accordingly identified and determined in-order to open new windows to the vehicle manufacturing industry. Following the mentioned goal; a camshaft is designed
