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The aim of this study was to evaluate the performance of an artificial intelligence (AI)-based method for automated segmentation of total metabolic tumor volume (TMTV) in 18F-FDG PET/CT scans of patients with lymphoma, using an independent, publicly available benchmark dataset curated and segmented by expert readers in a previously published study. Methods: The AI model, based on a 3-dimensional U
Pain is often the presenting symptom of acute pancreatitis (AP) and has a prognostic significance, with poorly treated pain affecting patient outcomes. Despite this, there are currently no international recommendations for pain management in patients admitted with AP. This current guideline was developed following the United European Gastroenterology framework for the development of high-quality c
The volume and complexity of scientific literature are expanding rapidly, making it increasingly difficult to extract and synthesize information across studies. This challenge is particularly acute in the biological sciences, where evidence spans multiple levels of organization and heterogeneous experimental designs. Large Language Model (LLM) pipelines offer a scalable route to evidence synthesis
Introduction – On-site sanitation systems (OSS) are the primary sanitation technology used to manage household fecal sludge in the Global South, including Kigali City. Poor quality OSS can lead to the spread of fecal-oral diseases and water resource pollution. Previous studies have demonstrated that OSS in Kigali are ineffective. In 2018, the Rwanda Standards Board adopted ISO 24521 to guide the d
We present a model dielectric function composed of critical point functions in order to parameterize the temperature and wavelength dependencies of the dielectric function of InAs. This model is based on Adachi’s critical point model, with simple wavelength-dependent analytical functions whose parameters change linearly with temperature. The calculated dielectric function at room temperature is in
Purpose: Meniscal calcifications are associated with meniscal degeneration and osteoarthritis (OA). However, differentiating calcification types, such as basic calcium phosphate (BCP) and calcium pyrophosphate (CPP), remains challenging in vivo. Therefore, assessing new imaging possibilities is crucial in understanding calcification pathologies and their relationship with OA. This study investigat
How does Security Force Assistance (SFA) impact Niger's security sector and beyond? I draw on extensive fieldwork in Niger and identify and analyse two developments taking place in Niger's security sector: the development of an expanded Special Forces Command and the elaboration of multiple mobile hybrid units. I build upon, and contribute to, existing studies related to the politicization and sec
We aimed to investigate socioeconomic differences between sexes and the influence on outcome following surgery for carpal tunnel syndrome (CTS) or ulnar nerve entrapment (UNE) at the elbow. Patients with CTS (n = 9000) or UNE (n = 1266) registered in the Swedish National Register for Hand Surgery (HAKIR) 2010–2016 were included and evaluated using QuickDASH 12 months postoperatively. Statistics Sw
Objective: To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA) and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serologic markers. Methods: We analyzed serum and plasma from three cohorts: presymptomatic individuals who later developed RA (n = 518), a subset of these at RA diagnosis
Bullous pemphigoid (BP) is the most common autoimmune blistering disease and has been linked to increased mortality, although previous studies have generally relied on small populations and no data have been available specifically for the Swedish population. This study aimed to evaluate the 1-and 10-year mortality rates and all-cause mortality in Swedish patients with BP compared with the ge
With the development of additive manufacturing, the freedom in developing complex cooling structures has been enlarged greatly. Topology optimization is one of the methods that can give out cooling structures beyond the limits of geometric parameters. In this research, an algorithm of topology optimization with heat transfer is derived. The detailed optimization procedure is presented in this work
Marine microorganisms have the potential to disperse widely with few obvious barriers to gene flow. However, among microalgae, several studies have demonstrated that species can be highly genetically structured with limited gene flow among populations, despite hydrographic connectivity. Ecological differentiation and local adaptation have been suggested as drivers of such population structure. Her
Northwest China's arid climate and fragile ecosystems are becoming wetter and greener. However, the rapid expansion of photovoltaic (PV) infrastructure in this region alters land-atmosphere interactions, with potential consequences for local climate and water resources. Here, we use a combined climate and dynamic vegetation modeling approach to assess the effects of hypothetical PV deployment acro
Contrasting the antigen-presenting dendritic cells (DCs) in the conducting airways, the alveolar DC populations in human lungs have remained poorly investigated. Consequently, little is known about how alveolar DCs are altered in diseases such as chronic obstructive pulmonary disease (COPD). This study maps multiple tissue DC categories in the distal lung across COPD severities. Specifically, sing
Background: Perinatal arterial ischemic stroke (PAIS) is a neurologic disorder leading to long-term complications. Mesenchymal stem cells (MSCs) have emerged as a novel therapeutic agent. This systematic review aims to determine the effects of stem cell-based interventions for the treatment of PAIS in preclinical studies. Methods: We included all controlled studies on MSCs in neonatal animals with
Purpose: This study aims to computational numerical simulations to clarify and explore the influences of periodic cellular lattice (PCL) morphological parameters – such as lattice structure topology (simple cubic, body-centered cubic, z-reinforced body-centered cubic [BCCZ], face-centered cubic and z-reinforced face-centered cubic [FCCZ] lattice structures) and porosity value ( ) – on the thermal-
Rectal cancer is a common cancer, with presently a 5-year survival of 67 %. Treatment is based on tumor stage, but current staging methods, such as magnetic resonance imaging (MRI) or ultrasound, are limited in the ability to correctly stage the disease. Magnetomotive ultrasound is a developing modality that has a potential to improve rectal cancer staging. Magnetic nanoparticles are set in motion
Most retrograde signalling research in plants was performed using Arabidopsis, so an evolutionary perspective on mitochondrial retrograde regulation (MRR) is largely missing. Here, we used phylogenetics to track the evolutionary origins of factors involved in plant MRR. In all cases, the gene families can be traced to ancestral green algae or earlier. However, the specific subfamilies containing f
The outer parts of the Milky Way's disc are significantly out of equilibrium. Using only distances and proper motions of stars from Gaia's Early Data Release 3, in the range |b| < 10°, 130° < < 230°, we show that for stars in the disc between around 10 and $14\, \mathrm{kpc}$ from the Galactic centre, vertical velocity is strongly dependent on the angular momentum, azimuth, and position above or b
The expansion of the European Union's (EU) regulatory sphere creates conflicts of sovereignty between the EU and its member states, and third countries that lack a possibility to participate in the making of those laws and policies. The conflict is epitomised in the concept of the Union's decision-making autonomy. Albeit stringently applied, the concept is ambiguous and undefined. This article end
