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AIMS: Diagnosing heart failure with preserved ejection fraction (HFpEF) remains challenging, particularly in older individuals. We hypothesized that machine learning (ML) approaches could improve diagnostic accuracy compared with HFpEF scores.METHODS: We evaluated the diagnostic performance of four supervised ML algorithms (random forest [RF], extreme gradient boosting [XGBoost], support vector ma

The evacuation dynamics of children have been attracting growing research interest. Compared to adult populations, the evacuation behaviours and self-rescue abilities of children can be limited due to their developmental changes. However, considering developmental differences among children of various ages is crucial to avoid oversimplifications. This chapter focuses on evacuation of children in t

What are the main challenges for fossil-free agriculture and food systems, according to Swedish farmers? And what do farmers think fossil-free farms should look like, and how should they function? What actions are needed from different actors to achieve these visions by 2050? These questions were discussed during a lunch-to-lunch workshop in Eskilstuna, 13-14 November 2025. The purpose of the work

Genetically determined color morphs are found in many animals. Polymorphism can be maintained by social selection if competitive interactions allow each morph to increase in frequency when rare. This reliance on negative frequency-dependent selection should make color polymorphism vulnerable to the appearance of novel phenotypes that disrupt competitive interactions among morphs. We show that the

Alzheimer’s disease (AD) is the most common form of dementia, and with an aging population, its burden will continue to rise, affecting families and straining societal resources. Biological changes in AD begin decades before symptoms appear, offering a crucial window for therapeutic intervention. Understanding the underlying mechanisms is essential for preventing or delaying disease onset. APOE4 i

Objective: In primary health care in southern Sweden, interprofessional medication reviews are conducted, to a limited extent, for patients living independently, with the purpose of optimising their pharmacological treatment. These medication reviews have identified and addressed many important issues regarding the patients’ medication. However, there is limited knowledge regarding the participati

Abstract – Background: Neutrophils, previously viewed as short-lived microbial killers, are now recognized as highly adaptable regulators of innate immunity. Advances in transcriptomic, metabolic, and epigenetic profiling reveal their remarkable heterogeneity and ability to adopt microenvironment-specific phenotypes. In the lung, this plasticity gives neutrophils a double role: they fight infectio

The magnesium, calcium, strontium and barium ions bind six, eight, eight and nine water molecules in the first hydration shell, and ca. 12, 16, 16 and 18 water molecules in the second one, in dilute aqueous solution, respectively. With increasing concentration of alkaline earth metal halides, water molecules in the second hydration shell are exchanged for hydrated chloride and bromide ions forming

In parallel with the exponential increase in extractivism around the world, comes social movements resisting such processes and advocating for alternative forms of development. Extractivism - a mode of accumulation associated with capitalism - is problematic due to the socio-ecological destruction that is embedded in its logics. Opposition to extractivism has intensified and in many instances, wom

Introduction: Stress urinary incontinence is the most prevalent type of incontinence among women, with mid-urethral sling (MUS) surgery considered the gold standard surgical treatment. Despite its widespread use, the role of mesh in this procedure has sparked controversy over the past decade. The primary objective of this study was to compare pelvic pain in women who have undergone MUS surgery wit

Radio frequency (RF) signal-based localization using modern cellular networks has emerged as a promising solution to accurately locate objects in challenging environments. One of the most promising solutions for situations involving obstructed-line-of-sight (OLoS) and multipath propagation is multipathbased simultaneous localization and mapping (MP-SLAM) that employs map features (MFs), such as vi

Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disease driven by pathological depositions of proteins that accumulate over decades. Compelling genetic and neurobiological evidence suggests that amyloid accumulation in the brain initiates and drives early-stage AD. Measurement of fibrillar amyloid has been pivotal to the development and approval of disease-slowing treatments. Various

Alzheimer’s disease is a complex and multifactorial disease characterized by two key pathological hallmarks: amyloid-beta plaques and tau neurofibrillary tangles. Recent progress has led to the development and approval of disease-targeted therapies for Alzheimer’s disease in the form of anti-amyloid-beta monoclonal antibodies. However, findings suggest that amelioration of multiple pathological dr

Although much progress has been made over the last decades, there is still a significant clinical need for novel therapies to manage cancer. Typical problems are that solid tumors are frequently inaccessible, aggressive, and metastatic. To contribute to solving some of these issues, we have developed a novel radioisotope-labeled 27 nm nanoparticle, 177Lu-SN201, to selectively target solid tumors v

Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and are among the foremost causes of disability globally. CVD burden has continued to increase in most countries since 1990, with trends driven by changing exposures to harmful risk factors, population growth, and population aging. Objectives: We report estimates of global, national, and subnational CVD burden, including

Volume 3 of the FCC Feasibility Report presents studies related to civil engineering, the development of a project implementation scenario, and environmental and sustainability aspects. The report details the iterative improvements made to the civil engineering concepts since 2018, taking into account subsurface conditions, accelerator and experiment requirements, and territorial considerations. I

Volume 1 of the FCC Feasibility Report presents an overview of the physics case, experimental programme, and detector concepts for the Future Circular Collider (FCC). This volume outlines how FCC would address some of the most profound open questions in particle physics, from precision studies of the Higgs and EW bosons and of the top quark, to the exploration of physics beyond the Standard Model.