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Osteoclast activity and the fine balance between bone formation and resorption is affected by inflammatory factors such as cytokines and T lymphocyte activity, mediated by major histocompatibility complex (MHC) molecules, in turn regulated by the MHC class II transactivator (MHC2TA). We investigated the effect of functional polymorphisms in the MHC2TA gene (CIITA), and two additional genes; C-type
The relation between delta O-18 of precipitation and temperature has been used in numerous studies to reconstruct past temperatures at ice core sites in Greenland and Antarctica. During the past two decades, it has become clear that the slope between delta O-18 and temperature varies in both space and time. Here, we use a general circulation model driven by changes in orbital parameters to investi
The mass of the top quark is measured in a data set corresponding to 4.6 [Formula: see text] of proton-proton collisions with centre-of-mass energy [Formula: see text] TeV collected by the ATLAS detector at the LHC. Events consistent with hadronic decays of top-antitop quark pairs with at least six jets in the final state are selected. The substantial background from multijet production is modelle
Single-molecule fluorescence spectroscopy and imaging probe many characteristics of the fluorescence from individual molecules like relative intensity, polarization, lifetime and spectrum. However, such an important and fundamental parameter as absolute fluorescence intensity (or in other words fluorescence brightness), which is proportional to the absorption cross section and fluorescence quantum
Objective: Advanced glycation end products (AGE) have been implicated in diabetic vascular complications through activation of pro-inflammatory genes. AGE-modified proteins are also targeted by the immune system resulting in the generation of AGE-specific autoantibodies, but the association of these immune responses with diabetic vasculopathy remains to be fully elucidated. The aim of this study w
The overall aim of this research was to investigate the safety of oral care in terms of intracranial dynamics and changes in oral health during intubation and 48 hours after extubation among neuroscience intensive care unit (NICU) patients. Additional aims included comparison of a comprehensive oral care protocol (i.e., tongue scraping, electric toothbrush, non-foaming toothpaste, and application
The widespread use of Au as a seed particle in the fabrication of semiconductor nanowires presents a fundamental limitation to the potential incorporation of such nanostructures into electronic devices. Although several other growth techniques have been demonstrated, the use of alternative seed particle metals remains an underexplored but potentially very promising way to influence the properties
Because of the emergence of strains of Mycobacterium tuberculosis resistant to first-line antituberculosis agents, one of the second-line drugs, p-aminosalicylate (PAS), has regained importance in the treatment of tuberculosis. The mode of action of PAS, however, remains controversial as to whether it inhibits mycobactin or folate biosynthesis. To unravel this, we have studied the effect of PAS on
A »manly» Queen with »feminine» charm. Gender perspectives. Existential biography does not so much search for a logical development in a person’s life as for the opportunities to shape and choose between different paths. Instead of using identities, which are often ambiguous in the extreme, I follow the Swedish historian Henrik Rosengren in his use of different cultural identifications that toget
Background: In evaluating complex interventions, it is a challenge for researchers to provide transparent reporting of the intervention content with sufficient detail and clarity such that effects can be compared across studies or countries. Objective: To describe and compare the content of current rehabilitation for patients with inflammatory arthritis across 4 northern European countries. Patien
BACKGROUND AND PURPOSE: Distal radius fractures are most often treated nonoperatively, but sometimes they are treated surgically when deemed unstable. Based on the literature, a consensus protocol for treatment has been developed in southern Sweden to aid clinicians in their decision making. We evaluated the results of this protocol prospectively using a validated outcome instrument (DASH) in a la
Various neuropsychiatric disorders are a common feature of today. Not least the adhd diagnosis. The aim of the article is to provide an alternative model for understanding adhd which differ from the otherwise dominant neurobiological perspective. The method used was to let a person – Anders who is almost 30 years – tell about his life and his adhd diagnosis. Through the told story it becomes clear
Detailed stratigraphic analyses of sediments deposited in Lake Botjarnen, a small boreal forest lake in the shield terrain of central Sweden, clearly reflect progressively increasing human impact on terrestrial and aquatic ecosystems following settlement and establishment of an iron industry in the 17th century. Rising frequencies of pollen and spores from light-demanding plants provide evidence o
Two types of main-chain type polybenzoxazines with amide and benzoxazine groups as repeating units in the main chain, termed as poly(amide-benzoxazine), have been synthesized. They have been prepared by polycondensation reaction of primary amine-bifunctional benzoxazine with adipoyl and isophthaloyl dichloride using dimethylacetamide as solvent. Additionally, a model reaction is designed from the
Gas turbine blade tips encounter large heat load as they are exposed to the high temperature gas. A common way to cool the blade and its tip is to design a serpentine passage with 180-deg turns under the blade tip-cap inside the turbine blade. Improved internal convective cooling is therefore required to increase the blade tip lifetime. In this paper, turbulent fluid flow and heat transfer through
This thesis has contributed to the methodological development in the field of assistive technology and has generated new knowledge about the effectiveness and the service delivery process when powered mobility devices are provided to adult first time users in a Nordic context. Some of the results have been used to investigate the relationship between the three key elements of Donabedian’s conceptu
