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The normal distribution of von Willebrand factor (VWF) levels is wide. Low levels are associated with bleeding symptoms and von Willebrand disease (VWD). We have recently described a high prevalence of bleeding symptoms in a whole age group of young females (n = 1,019) from Malmo, Sweden. It was the objective of the present study to evaluate the distribution of VWF levels in young females with or
Popular Abstract in Swedish På lång sikt drivs ekonomisk tillväxt av teknisk utveckling. Det är genom att kunna producera mer och bättre produkter givet samma insatsfaktorer som bruttonationalprodukten (BNP) växer i det långa loppet. Men vad är det då som genererar teknisk utveckling? Jo, satsningar på forskning och utveckling (FoU). Dock är det så att resultaten från FoU – ny kunskap och ny tekniThis thesis deals with the organization of R&D from a micro perspective in order to get a better idea of how to generate economic growth in the long run. What kind of R&D policies should be promoted? This thesis contributes to the existing literature by investigating other data sets than before, by using more modern econometric techniques and by extending the investigated variables. Chapt
Background: Despite a strong social gradient in the prevalence of obesity, there is little scientific understanding of obesity in people settled in deprived neighbourhoods. Few studies are actually based on objectively measured data using random sampling of residents in deprived neighbourhoods. In addition, most studies use a crude measure, the body mass index, to estimate obesity. This is of conc
A xylosylated carborane was synthesized by standard carbohydrate methodology and tested on normal HFL-1 cells as well as transformed T24 cells. The xylosylated carborane initiated glycosaminoglycan (GAG) synthesis in both cell lines and treatment with the carborane gave a pronounced translocation of proteoglycans to the nuclei of T24 cells. However, most of the boron-containing compounds were secr
An idea is presented where multitapers are extracted from a known cross-spectrum and applied for estimation of the co- herence function. An important property of the extracted win- dows are the time-delay between left and right tapers. There- fore, time-delayed Thomson multitapers are also proposed as an approximation. Simulations are performed using differ- ent linear filters as well as disturbin
Popular Abstract in Swedish Fysikalisk modellering och reglering av motorer En stor del av dagens forskning inom förbränningsmotorer är inriktad på att minska bränsleförbrukning och emissioner, utsläpp. De traditionella bensinmotorerna har förhållandevis låga emissionsnivåer medan dieselmotorerna har en lägre bränsleförbrukning. De förbränningskoncept som studeras i avhandlingen Physical ModelingThe topic of this thesis is model-based control of two combustion engine concepts, Homogeneous Charge Compression Ignition (HCCI) and Partially Premixed Combustion (PPC), using physics-based models. The studied combustion concepts hold promise of reducing the emission levels and fuel consumption of internal combustion engines. A cycle-to-cycle model of HCCI, including heat losses to the cylinder
Fracture Liaison Services are the best model to prevent secondary fractures. The International Osteoporosis Foundation developed a Best Practice Framework to provide a quality benchmark. After a year of implementation, we confirmed that a single framework with set criteria is able to benchmark services across healthcare systems worldwide. Introduction Despite evidence for the clinical effectivenes
The production of muons from heavy flavour decays is measured at forward rapidity in proton-proton collisions at root s = 7 TeV collected with the ALICE experiment at the LHC. The analysis is carried out on a data sample corresponding to an integrated luminosity L-int = 16.5 nb(-1). The transverse momentum and rapidity differential production cross sections of muons from heavy flavour decays are m
Background: Peripheral blood eosinophilia and lung mucosal eosinophil infiltration are hallmarks of bronchial asthma. IL-5 is a critical cytokine for eosinophil maturation, survival, and mobilization. Attempts to target eosinophils for the treatment of asthma by means of IL-5 neutralization have only resulted in partial removal of airway eosinophils, and this warrants the development of more effec
Many patients with asthma or chronic obstructive pulmonary disease (COPD) routinely receive a combination of an inhaled bronchodilator and anti-inflammatory glucocorticosteroid, but those with severe disease often respond poorly to these classes of drug. We assessed the efficacy and safety of a novel inhaled dual phosphodiesterase 3 (PDE3) and PDE4 inhibitor, RPL554 for its ability to act as a bro
In recent years the development and use of crash prediction models for roadway safety analyses have received substantial attention. These models, also known as safety performance functions (SPFs), relate the expected crash frequency of roadway elements (intersections, road segments, on-ramps) to traffic volumes and other geometric and operational characteristics. A commonly practiced approach for
This article takes the work of David Harvey as an example of the valuable research being done in the space between geography and history. Harvey's influence is described as being significant in the canonical debates within geography that have had a far-reaching impact outside that particular field. His production is summarized from three different perspectives. First, his contribution to the theor
Genetic predisposition for cardiovascular disease (CVD) is likely to be modified by environmental exposures. We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors.
Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression. Expression of TPD52, GATA3 and KRT18 was increased in KRT19 expressing patients.
Predictions of high-energy hadron activation of liquid argon in the calorimeter of A Thoroidal LHC ApparatuS (ATLAS) were carried out by folding particle flux spectra with the radionuclide production cross sections. Calculations were performed with a wide array of input data. Six sets of cross sections were folded with two sets of particle flux spectra, and the results were compared. The particle
This dissertation aims to contribute to the study of the relationship between religion and politics and especially research about Islam and Muslims in Sweden. The thesis analyzes how Islam and Muslims are depicted in Swedish public policy debates between 1975–2010. The research questions are: How are Islam and Muslims described in Swedish public policy? Which questions and in what circumstances ar
