Background. The question is debated on whether maternal hypothyroidism or use of thyroxin in early pregnancy affects the risk for infant congenital malformations. Objectives. To expand the previously published study on maternal thyroxin use in early pregnancy and the risk for congenital malformations. Methods. Data from the Swedish Medical Birth Register were used for the years 1996-2011 and infan

We investigate, through osmotic pressure measurements, the validity of the single-parameter equation of state (EOS) for solutions of polyethylene glycols in water, by Cohen et al.(1,2) We show that it is physically meaningful and that a reasonable good correspondence between the osmotic pressures for PEG35 in large range of concentrations is obtained. We also take the chain length dependence into

Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The most widespread underlying genetic deficiency is a heterozygous deficiency of the serine protease inhibitor Cl esterase inhibitor (C1-Inh). In addition to low C4 levels, the most important laboratory parameter for correct diagnosis of HAE or angioedema du

In this paper, we propose a practical and efficient method for finding the globally optimal solution to the problem of determining the pose of an object. We present a framework that allows us to use point-to-point, point-to-line, and point-to-plane correspondences for solving various types of pose and registration problems involving euclidean (or similarity) transformations. Traditional methods su

We use a strong two-colour laser field composed of the fundamental (800 nm) and the second harmonic (400 nm) of an infrared (IR) laser field to generate attosecond pulses with controlled spectral and temporal properties. With a second-harmonic intensity equal to 15% of the IR intensity the second-harmonic field is strong enough to significantly alter and control the electron trajectories in the ge

Negative pressure wound therapy in cardiac surgery Rainer Petzina, M.D. Clinical Sciences, Lund, Lund University Poststernotomy mediastinitis is a devastating complication for patients undergoing cardiac surgery. Conventional treatment includes surgical revision, continuous irrigation with drainage and wound closure with the use of the greater omentum and muscle flaps. Widespread adoption of ne

Fundamental features of the arc stability in a dc arc furnace of 720 V/100 kA/72 MW have been investigated. The Cassie-Mayr arc model has been employed and applied for the target dc arc furnace. In order to characterize the parameters of the Cassie-Mayr arc model and the behavior of unstable arc dynamics, the advanced arc simulations of magneto-hydrodynamics (MHD) have been performed. From the res

Objective To investigate the effect of high dose vitamin A supplementation given with BCG vaccine at birth in an African setting with high infant mortality. Design Randomised placebo controlled trial. Setting Bandim Health Project's demographic surveillance system in Guinea-Bissau, covering approximately 90 000 inhabitants. Participants 4345 infants due to receive BCG. Intervention Infants were ra

This study quantitatively diagnose the linkage between Total Solar Irradiance (TSI) and Earth's near-surface air temperature (TAS) of past 1000-year as simulated by Paleoclimate Modeling Intercomparison Project 3 (PMIP3) models. The results demonstrate that there is causal feedback of TAS from TSI variations, especially in the tropical and subtropical regions. The consistency between models in sim

Background: Leptin resistance is considered a primary risk factor for obesity. It has been hypothesized that dietary cereal grain protein could cause leptin resistance by preventing leptin from binding to its receptor. Non-degraded dietary wheat protein has been found in human serum at a mean level of 41 ng/mL. Here, we report our findings from testing whether enzymatically digested gluten from wh

Background: Acetaminophen, the major active metabolite of acetanilide in man, has become one of the most popular overthe- counter analgesic and antipyretic agents, consumed by millions of people daily. However, its mechanism of action is still a matter of debate. We have previously shown that acetaminophen is further metabolized to N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide (AM404) by fa

The relativistic projectile fragmentation of a 750 MeV per nucleon beam of Ag-107 was used to populate isomeric states in neutron-deficient nuclei around A=80-90. Reaction products were separated and unambiguously identified using the GSI FRagment Separator (FRS) and its ancillary detectors. At the final focal plane, the fragments were slowed from relativistic energies by means of an aluminium deg

The relevance of the intrinsic subtypes for clinical management of metastatic breast cancer is not comprehensively established. We aimed to evaluate the prevalence and prognostic significance of drifts in tumor molecular subtypes during breast cancer progression. A well-annotated cohort of 304 women with advanced breast cancer was studied. Tissue microarrays of primary tumors and synchronous lymph

Popular Abstract in English The purpose of this dissertation is to produce a cohesive study on how income is related to different events that constitute fertility, such as entry into parenthood, continued childbearing, and the risk of remaining childless. Relying on register-based longitudinal data on men and women living in Sweden between 1968 and 2009, this study aims to contribute to the literaThe purpose of this dissertation is to produce a cohesive study on how income is related to different events that constitute fertility, such as entry into parenthood, continued childbearing, and the risk of remaining childless. Relying on register-based longitudinal data on men and women living in Sweden between 1968 and 2009, this study aims to contribute to the literature by providing insight in

Popular Abstract in Swedish Varje år insjuknar mer än 8000 kvinnor i Sverige i bröstcancer, och 5 år efter diagnos är nära 90% fortfarande i livet. Trots att prognosen för majoriteten av patienterna är god, dör 1400 kvinnor årligen av bröstcancer. Till följd av detta pågår mycket forskningsarbete för att finna faktorer som bättre kan förutsäga prognos, prognostiska studier, men även för att finna Breast cancer is the most common tumour form and the second leading cause of death in solid tumours in women in the Western world. Despite improvements in the treatment, a considerable number of patients will relapse and die from their breast cancer. At the same time, a substantial number of patients will be over-treated, as they would have been cured by surgery and radiotherapy alone. In the meta