Search results

Background: Inducible nitric oxide synthase (iNOS) is a key driver of aberrant angiogenesis in inflammatory conditions and cancer, making it an attractive therapeutic target. Nevertheless, its function can be affected by the complex immune responses and tumor microenvironment (TME). Hence, combinatorial treatment approaches that simultaneously target iNOS and immune-modulatory signaling are strong

Sedan RUT-avdraget infördes 2007 har sektorn för hushållsnära tjänster expanderat, och personer över 65 år utgör idag en av de största användargrupperna (Riksrevisionen 2020:34). Ett växande antal företag erbjuder tjänster som riktar sig till äldre och deras anhöriga. Utifrån intervjuer med RUT-företag, arbetsgivarorganisationer och fackförbund är syftet med artikeln att analysera omsorgstjänstern

"If on a winter’s night an architect" was developed and presented within the Milano International Design Studio (MInDS) at Politecnico di Milano as an intensive workshop focused on model production.The work was produced exclusively through physical models, understood not as representations of predefined designs but as tools for thinking. Through iterative processes of making, testing, and reconfig

Antibiotic resistance poses a global threat. Antibiotics are administered to 80-90% of terminally ill patients but evidence of their effectiveness in improving survival or symptom relief at the end of life (EOL) is scarce. To determine the proportion of deceased patients that continue antibiotic treatment after documented EOL discussion and the decision to prioritise symptom relief over active tre

The diagnostic accuracy of AIDOC-VO, the first commercial artificial intelligence tool for intracranial large-and medium-vessel occlusion (LVO/MeVO) detection on head-and-neck CT angiography (CTA), was evaluated in a multicenter emergency setting. A prospective diagnostic-accuracy study of 3,031 adult CT angiograms (mean age, 67.3 years ± 16.4 [SD]; 1,549 females) acquired March-July 2024 across a

BACKGROUND AND AIMS: Guideline-directed medical therapy (GDMT) for heart failure (HF) is underutilized in primary care, particularly among older adults with chronic stable HF. This prospective quality improvement study, Heart Failure in Southern Sweden (HISS), evaluated the impact of a cross-disciplinary implementation project combining cardiology and primary care expertise to enhance GDMT adheren

Cohesionless loose granular material (CLGM), defined by the absence of interparticle cohesion and a fragile packing structure, are highly sensitive to mechanical disturbances and exhibit fluid-like dynamics under shear. This study investigates the nonlinear behavior arising from the interaction between an auger drill and CLGM through a combination of laboratory experiments and discrete element met

The hypothalamus and sex hormones are closely linked to primary headache disorders. Migraine is the most prevalent disabling neurological disorder, affecting up to 15% of the global population, with enormous socioeconomic and personal impacts. It ranks second among years lived with disability (YLD), with women being the most affected, experiencing a threefold higher prevalence than men. Women repo

This study explores causes for uncertainty that social workers experience when making assessments ofout of home placements in foster or institutional care. Uncertainty is often considered to be an integralpart of professional decision making, and the reason why professions are needed at all. Most researchhas concentrated on investigating how uncertainty is approached in education, professions, and

We present an extension of the SPL-BEV (Soccer Player Localization for Bird’s-Eye-View) method, introducing Decomposable Tiled SPL-BEV (DTSPL-BEV), a variant designed to enable efficient inference on embedded devices. We show specialized tiling algorithms that enable inference on a given devices with some known memory limitations, while also ensuring the same detection results as running inference

This article examines the emerging migration corridor between Uzbekistan and Sweden based on interviews, focus groups, and data from a survey conducted in both countries in 2024. Although small in scale, this corridor is analytically significant for understanding the diversification of Uzbek migration beyond Russia and Turkey. Findings show that demographic pressures, limited employment, and envir

Thermal performance curves (TPCs) capture how population growth depends on temperature. When temperatures increase, such as during global change, TPCs may evolve to match new environmental temperatures. While previous studies mostly focus on population growth rate TPCs, evolution can also be strongly trait-dependent and require a multi-trait analysis. Here, we empirically tested how TPCs and multi

En växande grupp barn och unga i Sverige uppvisar skolvägran och ökande psykisk ohälsa, ofta i kombination med höga krav, otillräckligt stöd och svårigheter att hantera skolvardagen. Skolsköterskan har en central roll i tidig upptäckt och stöd, men saknar i dag gemensamma arbetssätt och språk för att aktivt bidra till elevernas återgång till skolan. Därför söker vi skolsköterskor med minst två års

Mannosyl β-C-1 amidotriazoles have previously been reported to have higher selectivity for galectin-9N (N-terminal domain) than the corresponding galactoside C3 amidotriazoles have, which were more selective for galectin-3. This study further investigated this by synthesis of mono- and bis-aryltriazolyl mannoside analogues to known high-affinity galectin-3 galactosyl-derived inhibitors. Following

Target cell entry of HIV-1 is dependent on the binding of gp120, the outer component of the viral envelope glycoprotein complex (Env), to CD4 and a coreceptor, preferentially CCR5 or CXCR4. Still, other interactions may also contribute to the infectivity of the virus. One such interaction is between the highly glycosylated gp120 and carbohydrate-binding proteins, such as galectins. Here, we studie

The pressure to design, develop and implement systems that exploit the potential of technological innovation in effective and efficient ways that contribute to the organisational goals never ceases. Post 1945 industrialisation evolved from mechanisation of industrial processes through to computerisation to the age of digitalisation and beyond. From the study of mechanisation of work in coal mining

This chapter discusses trade-offs that need to be struck while developing Unmanned Aircraft Systems (UAS) operations. Ten trade-offs are outlined, pertaining to technical systems, to human operators, and to the combined sociotechnical system in its operational and organizational environment, which have implications for Human-Systems Integration (HSI) in multiple phases of the systems engineering l

BACKGROUND: The incidence of postoperative pulmonary complications (PPCs3) following abdominal surgery varies across surgical specialties. It remains unclear to what extent the incidence of PPCs is attributable to known patient-related factors and anaesthesia duration, rather than to differences inherent to the surgical specialty itself.METHODS: Post-hoc analysis of an observational study describi

IntroductionForensic assessments of whether an injury would have been life-threatening often rely on empirical knowledge rather than evidence-based criteria. To address this gap, we applied the validated trauma scoring system New Injury Severity Score (NISS) to estimate mortality risk along the natural course of single stab injuries to the trunk.Methods and materialsWe included 408 survivors and 1