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Generalized anxiety disorder (GAD) is a severe and prevalent disorder among older adults. Cognitive behaviour therapy (CBT) is recommended treatment for GAD, but older adults benefit less than younger peers. Physical exercise has been suggested to improve treatment efficacy. We aimed to determine the efficacy of augmenting CBT with physical exercise for older adults with GAD. This randomised contr
We describe the complete larval development of the pedunculated barnacle Capitulum mitella, using both light microscopy and scanning electron microscopy. This includes all six naupliar instars and the final cypris stage. Many previous accounts on the development of barnacle larvae suffer from a shortage in detail and habitually use terminologies that are either inconsistent or hard to compare with
To reduce bird collisions with wind turbines, automatic detection systems have been developed to slow the blades down when a bird is approaching. We experimentally tested whether blade rotational speed (i.e., number of rotations per min) and frequency (i.e., number of times a blade passes a point per min) affected the decision time (i.e., time to take-off), path choice (i.e., the position in the a
Objective: To evaluate the safety, adherence, and efficacy of self-administered balance and resistance exercise using the Borg scale in patients with chronic kidney disease, and to examine relationships between exercise intensity or duration and baseline measures, and relationships between change in physical performance and baseline measures, intensity, or duration. Design: Post-hoc analysis of a
What is the context?: Platelets contain three major types of granules (alpha granules, dense granules and lysosomal granules) that carry distinct cargo. Dense granules store small molecules such as calcium, serotonin and adenosine 5′-diphosphate (ADP) that are essential for platelet activation and aggregation. Impaired production or release of dense granules can affect blood clotting and cause inc
Characterizing the onset and progression of Alzheimer’s disease pathologies relative to one another is important for biological staging and clinical trial design. Recent advances in blood plasma assays of Alzheimer’s disease amyloid and tau pathology have enabled detection of Alzheimer’s disease pathophysiology during life, but it remains unclear when plasma biomarker abnormalities are detectable
This study investigates how rescue service response times and staffing solutions relate to both citizen satisfaction with rescue services and the adoption of individual fire safety measures in Sweden. Data were drawn from Statistics Sweden's satisfaction index, rescue service response times from KOLADA, and survey data from the Swedish Civil Contingencies Agency on ownership of functional smoke de
In many research fields of the social sciences, attempts have been and are being made to integrate Darwinian evolutionary theory into their own work. The motivation and benefits of integration can vary from field to field and range from considering biological foundations for social phenomena to the application of methods and study designs from outside the field. Furthermore, Darwinian evolutionary
Endoscopically, the villi of the small bowel in intestinal lymphangiectasia typically appear white and may be swollen. Less commonly, tiny white spots are visible in the mucosa. The whitish discoloration of the villi is caused by chylomicrons, which accumulate in and obstruct the dilated lymphatic capillaries. These changes can also be demonstrated histologically. Lymphangiectasia is characterized
Network analysis has been recently adopted by the field of psychology to explore networks of symptoms in psychopathology, and wider interactive networks of biological, behavioral, and psychological factors influencing mental health. The network theory of psychopathology conceptualizes symptoms of mental disorder as causally connected, rather than being caused by disease or an underlying latent var
Background:Serious illness conversations are an iterative, interprofessional, team-based process that includes recommendations about medical care. Yet, it is not clear how clinicians in different role groups work together in this process.Objectives:We sought to examine how interprofessional clinicians in the medical intensive care unit (MICU) who were trained in the serious illness care program (S
Editorial for the special issue of "Small Structures"
Disorder is an intrinsic feature of all solids, from crystals of atoms to superlattices of colloidal nanoparticles. Unlike atomic crystals, in nanocrystal superlattices, a single misplaced particle can affect the positions of neighbors over long distances, leading to cumulative disorder. This elusive form of collective particle displacement leaves clear signatures in diffraction, but little i
BACKGROUND: We hypothesized that the main barriers to integrating exercise in routine care of patients with chronic kidney disease (CKD) were structural within European healthcare systems rather than due to resistance among healthcare professionals or patients.MATERIALS AND METHODS: This descriptive cross-sectional study used anonymized questionnaires to investigate nurses' and physicians' attitud
This study investigated the retention of spatial knowledge in buildings following route-learning training in a virtual reality environment. A total of 121 participants were tested up to three months later on putting waypoints of the route in the correct order and recalling directions at waypoints. Memory accuracy declined over time, consistentwith classic memory theory. Route knowledge was retaine
Background/Aim: Circumferential resection margin (CRM) has been shown to be a strong predictor of risk of local recurrence (LR) and distant metastases (DM) in patients with rectal cancer treated with total mesorectal excision (TME). However, not all patients with a CRM of zero develop LR or DM. This study aimed to identify factors associated with disease-free survival (DFS) despite non-radical exc
Purpose: High-risk colon cancer may benefit from preoperative chemotherapy (preCHT), but evidence on its short-term safety and outcome is limited. Population-based evidence before its incorporation into national guidelines is lacking. Methods: Patients with final weighted stage II–III colon cancer undergoing elective resection between 2007 and 2017 were identified in the Swedish Colorectal Cancer
AIM: This retrospective observational cohort study aimed to investigate the prevalence of suspected lateral lymph node metastases (LLNM), as diagnosed by magnetic resonance imaging (MRI), and its impact on local recurrence (LR) and overall survival (OS). Patients who underwent dissection of suspected lymph nodes were evaluated in subgroup analysis.METHOD: Patients diagnosed with rectal cancer in S
Objective To characterize the redistribution patterns of zinc and calcium ions during human sperm capacitation and to investigate their roles in sperm maturation and fertilization. Design In vitro experimental study using synchrotron-based x-ray fluorescence microscopy and complementary immunohistochemistry to assess elemental changes during different capacitation stages at nanometric spatial reso
This is a paper about gymnastics and a primordial form of geological knowledge. It pursues an interpretation of gymnastics, broadly defined, as a philosophy that interrogates what the Earth is. The goal is to reconstruct the epistemic implications of gymnastic practice in order to understand the evolution of animal motility as a prototypical form of geological knowledge. Since gravity is a global
