Objectives. SLE is a systemic autoimmune disease with an annual incidence of 3.8 per 100 000. Several pathogenic mechanisms are believed to be operating in SLE, including an impaired clearance of apoptotic cells, activation of the type I IFN pathway and generation of autoimmune leucocytes. Growth arrest-specific protein 6 (Gas6) and its receptor Axl are known to regulate inflammation and may be im

We describe realizations of the color analogue of the Heisenberg Lie algebra by power series in non-commuting indeterminates satisfying Heisenberg's canonical commutation relations of quantum mechanics. The obtained formulas are used to construct new operator representations of the color analogue of the Heisenberg Lie algebra. These representations are shown to be closely connected with some combi

Popular Abstract in Swedish Denna avhandling diskuterar hur en föreställning om enhet har präglat västerländskt politiskt tänkande om politisk gemenskap. Den visar att ett antagande om likhet, återspeglad i tid, rum, språk och rationalitet, har setts som en förutsättning för politisk gemenskap. Antagandet om likhet innebär att varje försök att utvidga gemenskapen ger upphov till nya exkluderingar This thesis argues that the Western thinking of political community has assumed the community to require a unity or unifying principle that serves as delineation. It suggests that sameness, reflected in history, space, language, or reason, has been assumed as the condition of possibility of the political community. Consequently, a particular identity is made a prerequisite for membership and vouch

Context: Dipeptidyl peptidase-4 (DPP-4) inhibitors act by increasing plasma levels of glucagon-like peptide-1 (GLP-1) and suppressing excessive glucagon secretion in patients with type 2 diabetes (T2DM). However, their effects on the glucagon response to hypoglycemia are not established. Objective: Assess effects of the DPP-4 inhibitor vildagliptin on alpha-cell response to hyper- and hypoglycemia

Functioning of the immune system requires the coordinated expression and action of many genes and proteins. With the emergence of high-throughput technologies, a great amount of molecular data is available for the genes and proteins of the immune system. However, these data are scattered into several databases and literature and therefore integration is needed.

Training studies in children have suggested that endurance training can give enlargement of cardiac dimensions. This relationship has not been studied on a population-based level in young children with objective methods. A cross-sectional study was made of 248 children (140 boys and 108 girls), aged 8-11 years, from a population-based cohort. Left ventricular end-diastolic diameter (LVDD) and left

Dopamine replacement for Parkinson's disease (PD) have seen three major iterations of improvements since the introduction of l-3,4-dihydroxyphenylalanine (l-DOPA) pharmacotherapy: dopamine receptor agonists, ex vivo gene transfer for cell transplantation and most recently in vivo gene therapy. In this chapter, we describe the principles behind viral vector-mediated enzyme replacement in PD. We foc

Background Family history is a strong risk factor for prostate cancer. The aim of this study was to investigate whether increased diagnostic activity is related to the incidence of prostate cancer among brothers of men with prostate cancer. Methods Data were from the nationwide population-based Prostate Cancer Database Sweden (PCBaSe Sweden), which includes data from the National Prostate Cancer R

Interstitial laser thermotherapy was used to treat rat liver tumours. The aim was to investigate the influence of temperature and temporary hepatic inflow occlusion on tumour growth and blood perfusion.

Life-space mobility refers to the spatial area in which a person moves in daily life, taking into account distance, frequency and assistance needed. The aim was to examine how changes in life-space mobility are associated with changes in quality of life (QOL) over a 2-year period.

Om hotet om kärnvapenkrig under kalla kriget i amerikanska spelfilmer.