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Objective: The incidence of autoimmune diseases, especially inflammatory bowel disease (IBD), has increased substantially. Globally, there are vast differences varying from 0.2/105 in some Asian countries to over 80/105 in the Faroe Islands. Environmental factors have been suggested as triggers. The aim was to investigate the incidence and prevalence of IBD in the 33 municipalities in the county S
Purpose: The aim of this study was to examine if exposures to chemicals at the workplace were associated with an increased risk of postmenopausal breast cancer, using improved exposure estimates. Methods: The design is a case–control study, nested within a cohort of women from the Malmö Diet and Cancer Study. The study comprised 2400 women, 731 cases and 1669 matched controls, born 1923–1950 and l
Introduction: A laparotomy is commonly required to gain abdominal access. A safe standardized access and closure technique is warranted to minimize abdominal wall complications like wound infections, burst abdomen and incisional hernias. Stitches are recommended to be small and placed tightly, obtaining a suture length-to-incision length (SL/WL) ratio of ≥ 4:1. This can be time-consuming and diffi
Purpose: [18F]flortaucipir binds to paired helical filament tau and accurately identifies tau in Alzheimer’s disease (AD). However, “off-target” binding interferes with the quantification of [18F]flortaucipir in several brain regions. Recently, other tau PET tracers have been developed. Here, we compare [18F]flortaucipir with the novel tau tracer [18F]RO948 head-to-head in vivo. Methods: We includ
It is essential to gain knowledge about the causes and extent of migratory connectivity between stationary periods of migrants to further the understanding of processes affecting populations, and to allow efficient implementation of conservation efforts throughout the annual cycle. Avian migrants likely use optimal routes with respect to mode of locomotion, orientation and migration strategy, infl
Background: Cartilage oligomeric matrix protein (COMP) is a pentameric cartilage protein also expressed in breast cancer tumors. A high expression of COMP evaluated by immunohistochemical staining is as an independent prognostic marker associated with poor patients’ prognosis. Methods: Herein, levels of COMP were analyzed using an IVD approved ELISA in serum samples from 233 well-characterized bre
This document presents design considerations of a sample for accelerated thermal aging tests. The proposed specimen is a parallel wired solenoid that is evaluated by using an axi-symmetric 2D finite element (FE) model in Comsol multi-physics. The aim of the design model is visualizing an interior stress distribution of an idealized coil in order to interpret the physics-of-failure in a more comple
Surveying disease vectors is currently excessively laborious for continuous and widespread monitoring. Wing beat modulation spectroscopy gives opportunity for species and sex recognition in electronic traps or mosquito target classification in lidar. We used a polarimetric dual-wavelength-band laboratory system to record kHz modulated backscattered light from insects. The system operates in the ne
In the advanced stages, malignant melanoma (MM) has a very poor prognosis. Due to tremendous efforts in cancer research over the last 10 years, and the introduction of novel therapies such as targeted therapies and immunomodulators, the rather dark horizon of the median survival has dramatically changed from under 1 year to several years. With the advent of proteomics, deep-mining studies can reac
Climate changes induce warmer climate with stronger and more frequent extreme events. Due to the uncertain nature of climate, accurate simulation of future conditions is impossible and a major challenge is the selection of climate data in the impact assessment. This work compares application of three climate data sets in an energy simulation of the EPFL campus: i) Regional Climate Models (RCM data
Massively parallel DNA sequencing opens up opportunities for bridging multiple temporal and spatial dimensions in biodiversity research, thanks to its efficiency to recover millions of nucleotide polymorphisms. Here, we identify the current status, discuss the main challenges, and look into future perspectives on biodiversity genomics focusing on insects, which arguably constitute the most diverse
Atria are implemented in buildings to increase daylight, foster interaction and provide ventilation. However, their implementation can be complex if good daylight is to be achieved. This research proposed an investigation about the atrium parameters that affect daylight conditions in a case study. This evaluation concentrated in the atrium geometry and the wall reflectance values. Overall, the out
Focusing on subjective evaluations of daylight conditions, the present paper explores the relation between room geometric characteristics and perceived brightness and daylight distribution in residential spaces. The study was conducted in 35 apartments consisting of 105 different rooms in the city of Malmö, and selected with respect to typical Swedish architectural building typologies. Questionnai
Brachylaena discolor (Asteraceae) is a medicinal plant used in Mozambique to treat stomachache, tuberculosis, and diabetes. To discover new lead compounds with leishmanicidal activity, a methanolic extract of the leaves of this plant was investigated. Through fractionation, employing several chromatographic methods, two sesquiterpene lactones onopordopicrin (1) and its germacronolide epoxide deriv
Romulus Bucur is a renowned writer and literary critic. He is also faculty member at Transylvania University of Brasov, institution well-known for its courses of creative writing and translation studies. "Glosses" is a nimbly written theoretical book wherein many topics are analyzed. One of the most important is the work of Alexandru Musina, editor, writer, professor, and mentor of the Group of Br
BackgroundThe overall aim of this thesis was to improve the oncological treatment strategies in esophageal and gastric adenocarcinoma (EGAC). Podocalyxin-like protein 1 (PODXL) has been associated with poor prognosis in other cancers and we wanted to investigate its potential role as a prognostic and predictive biomarker in resectable EGAC. Another aim was to assess how dose reductions and treatme
