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Cerebrospinal fluid (CSF) α-synuclein (α-syn) seed amplification assays (SAAs) can detect Lewy body pathology (LBP) with high accuracy but are invasive and costly. To address these challenges, this study evaluated a two-step workflow combining prescreening via smell-function testing with confirmatory CSF α-syn SAA testing only in individuals with reduced smell, for predicting postmortem LBP status
From June to November 1945, over 70 shipments of flat-packed architectural elements arrived at the harbours of Nexø and Rønne on the Danish island Bornholm. The shipments consisted of prefabricated interior fixtures and ready-to-be mounted walls. The Danish municipality prepared infrastructure, named new roads, and within a year, 300 wooden houses were assembled on site. The buildings, SvenskehuseFrom June to November 1945, over 70 shipments of flat-packed architectural elements arrived at the harbours of Nexø and Rønne on the Danish island Bornholm. The shipments consisted of prefabricated interior fixtures and ready-to-be mounted walls. The Danish municipality prepared infrastructure, named new roads, and within a year, 300 wooden houses were assembled on site. The buildings, Svenskehuse
A substantial external force transmitted to the brain may cause a severe traumatic brain injury (sTBI) , resulting in structural brain damage and/or functional impairment. Despite progress in management, traumatic brain injury remains a major cause of severe disability and death. This thesis evaluates treatment strategies and novel interventions in children and adults with sTBI and comprises the f
We report an unusual case of a patient presenting with Cushing’s syndrome caused by a phaeochromocytoma secreting adrenocorticotropic hormone (ACTH). The patient had a history of treatment-resistant hypertension, secondary amenorrhoea and tendency towards hypokalaemia. She had multiple signs of Cushing’s syndrome, such as swelling, bruising, abdominal striae and proximal myopathy. Hypokalaemia is
Transferring patients from the ward of their specialty or consultant is described as boarding. 1 Boarding patients is becoming increasingly prevalent due to greater pressure on hospital capacity. This practice compromises patient safety through delayed investigations, prolonged hospital stays, and increased risk of hospital-acquired infections. 1 2 We evaluated how regularly boarded patients were
Against the backdrop of the ecological crisis, food production systems will need to transform to ensure future food security. There are contrasting visions of what this transformation should look like. This paper scrutinizes these competing imaginaries of future agriculture and associated styles of anticipation in Tanzania. We find that both government visions and global crop models anticipate fut
Carbon farming is increasingly promoted as a strategy to achieve net-zero climate targets. This paper examines voluntary carbon market programmes through a global inventory and discourse analysis to identify key actors and how they frame and implement carbon farming. Findings show that agri-chemical firms, agri-tech companies, and new carbon farming startups mainly target large-scale farmers in th
This study protocol outlines the test evaluation of the design of a comprehensive Nordic hospital at home (HaH) digital education program entitled “the Nordic Digital Health and Education” program (NorDigHE). The NorDigHE program aims to prepare healthcare professionals for healthcare provision in a HaH context. The program, developed by a Nordic consortium, spans five modules over 3.5 weeks of fu
ObjectiveAs part of our research on Swedish school principals, we examined the occurrence and co-occurrence of conflicts and five negative acts (i.e. harassment, sexual harassment, threats of violence or physical harm, physical violence, bullying), their attributed sources, and their associations with self-rated health, workability, and general life satisfaction among 2670 principals.ResultsDuring
Purpose: Children with delayed reconstruction of esophageal atresia (DREA) have a high risk of morbidity. The aim of this study was to determine the prevalence of feeding difficulties in children with DREA, differences to children with primary anastomosis (PA) and identify risk factors for feeding difficulties in children with DREA. Methods: Parents of 30 children with DREA, born 2001–2018, were r
Variation enables short-term evolution (microevolution), but its role in long-term evolution (macroevolution) is debated. Here, we analyzed a dataset of Drosophila wing variation across six levels of biological organization to demonstrate that microevolutionary variation and macroevolutionary divergence are positively correlated at all levels from variation within an individual to macroevolution o
Recognizing individual variability is essential for developing targeted, personalized medical interventions. Vocal fatigue is a prevalent symptom and complaint among occupational voice users, but its identification has yielded mixed results. Vocal fatigue is a complex issue with heterogeneous biophysiological responses to vocal demands among individuals. This research aims to classify individuals
The peptide Ac-KGSFSIQYTYHVD-CONH₂ (KD), derived from residues 37–49 of human semenogelin I, forms a pH-responsive hydrogel in an aqueous environment with tunable mechanical properties that evolve over time. We hypothesize that KD self-assembles into a hydrogel through a pH-dependent mechanism involving predominantly a change in histidine protonation state, leading to structural transformations th
This thematic issue explores the complex and often controversial intersection of foster care and financial compensation. While foster care is often seen as a more inclusive and family‐oriented alternative to institutional care, the role of money in caregiving remains morally and socially sensitive. Drawing on sociological theories, particularly Viviana Zelizer’s concept of “hostile worlds,” the ar
The building sector accounts for a significant portion of global final energy use and greenhouse gas emissions, demonstrating the need to find low-carbon alternatives to new construction. Adaptive reuse offers a sustainable alternative to new construction, yet early-stage assessments of reuse potential often rely on surface-level metrics, failing to consider a building's internal spatial logic. Th
