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The ever-evolving understanding of the neuronal systems involved in Parkinson's disease together with the recent advances in recombinant viral vector technology has led to the development of several gene therapy applications that are now entering into clinical testing phase. To date, four fundamentally different approaches have been pursued utilizing recombinant adeno-associated virus and lentivir
In this paper we investigate a generalization of Gallager's (1963) low-density (LD) parity-check codes, where as component codes single error correcting Hamming codes are used instead of single error detecting parity-check codes. It is proved that there exist such generalized low-density (GLD) codes for which the minimum distance is growing linearly with the block length, and a lower bound of the
EWSR1 is involved in chimeric proteins which play crucial roles in the development of a variety of bone and soft tissue tumors. Many of the chimeric genes involving EWSR1 have been extensively studied, whereas less is known about the wild-type (wt) gene and its regulation. As the expression of the chimeric gene is driven by the EWSR1 promoter, it is of importance to study the mechanisms regulating
Peak matched multiple windows (PM MW) were used to estimate the spectrogram of the electroencephalogram (EEG). The authors focussed on the ability to estimate frequency changes, and especially resolving close peaks. A peak of known frequency was evoked in the EEG in a predetermined time interval. The PM MW spectrogram was compared to the commonly used single Hanning window and to weighted overlapp
Students working in groups is a commonly used method of instruction in higher education, popularized by the introduction of problem based learning. As a result, management of small groups of people has become an important skill for teachers. The objective of our study is to investigate why conflicts arise in student groups at the Faculty of Engineering at Lund University and how teachers manage th
We use the frequency doubled light from an optically trapped lithium niobate particle for non-intrusive scanning near-field optical microscopy. The detected power from this 50-100 nm diameter probe is currently tens of pW and is expected to approach nW with an improved detection system. The current experimental resolution is approximately 0.5 [mu]m, while the ultimate theoretical resolution is 70-
Background: Clinical studies have evaluated a correlation between preoperative walking capacity or function and outcome after hip and knee joint replacement surgery with contradictory results. Our aim was to investigate the effect of preoperative metabolic and/or aerobic exercise on surgical outcome, as well as to evaluate the effect of cumulated exercise by using a cutoff value at 3.5 hours throu
This study provides empirical evidence for long memory in the volatility process of VIX futures returns and investigates the practical importance of modelling it when calculating Value-at-Risk (VaR) for VIX futures and pricing VIX options. The analysis is performed using the GARCH, APARCH, FIGARCH and FIAPARCH models with the normal and skewed Student-t distributions. The VaR analysis shows that t
Abstract in FrenchDecay-prediction models can be used to predict the service life of wooden components. However, knowledge of how the material climate, i.e. moisture content and material temperature, varies with time is required. A reliable material climate prediction model is therefore crucial in situations when measurements are not viable. The aim of this paper is to develop and assess the perfo
