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Metachromatic leukodystrophy (MLD) is a rare autosomal recessive lysosomal storage disorder caused by disease-causing variants in the gene coding for arylsulfatase A, leading to deficient enzyme activity and subsequent accumulation of sulfatides. MLD is characterized by demyelination and neurodegeneration of the central and peripheral nervous system, manifesting as progressive motor and cognitive
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Uncertainty in the mechanical properties and modal characteristics of Cross-Laminated Timber (CLT) significantly impacts its predictive design and analysis. While previous studies have focused on identifying sensitive mechanical properties of CLT using model updating, the uncertainty quantification of these properties and their influence on natural frequencies and modes remain underexplored. This
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Uveal melanoma (UM) is a rare but frequently metastasizing cancer. Genome-wide association studies have identified three common genome-wide significant germline risk loci. Here, we perform a genome-wide association study on 401 new cases and conduct a meta-analysis with three independent previously published cohorts for a total sample size of 2,426 cases. We confirm the three previously identified
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Accurately mapping crop types in smallholder farming regions is crucial for monitoring crop dynamics and estimating production but remains challenging, especially over large extents. Remote sensing based crop mapping studies in smallholder farming regions often focus on major crops and the challenge of mapping small fields. However, minor but possibly emerging crops are often overlooked, nor is th
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It is by now a common trope that youth climate activism has become a ‘global phenomenon’. Yet, it also has significant regional variations. This literature review analyses eighteen academic articles on the topic of youth climate activism in Asia. We found that the literature from Asia overall had ambitions to contextualise and nuance international scholarship on youth climate activism. This was ac