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A new approach to targeting cell adhesion in oncology was recently suggested by observations made in patients with bladder cancer. Intravesical alpha1-oleate treatment triggered rapid tumor cell detachment into the urine and a parallel reduction in tumor number and size. This study identified alpha1-oleate as a potent inhibitor of multiple cell adhesion families in shed cells and tumor biopsies fr
Syftet med denna studie är att analysera debatten om ”Drag Queen Story Hour” i Sverige och därmed förstå hur den så kallade anti-genusrörelsen tar sig uttryck i en svensk kontext. Studien använder en metod som kombinerar kritisk diskursanalys med tematisk analys av materialet. Genom dessa metoder är målet att undersöka såväl debattens retoriska aspekter som den rådande diskursen. För att besvara fThe purpose of this study is to analyze the debate about drag queens story hour in Sweden and thus to understand how the anti-gender movement is expressed in a Swedish context. The analysis method that I chose for the study is inspired by the critical discourse analysis as well as a thematic analysis of the material. Using these methods the aim of the study is to examine the rhetoric aspects of th
Heterogeneous explainable spatiotemporal graph neural networks for disease outbreak surveillance using individual and aggregated-level data Fine-scale forecasting of severe infectious-disease outcomes can support local public-health planning, but most spatiotemporal forecasting models represent geographic areas as homogeneous nodes and do not explicitly retain information from individuals and hous
This thesis examines whether Chile's governance of its two strategic minerals, copper and lithium, has moved its economy beyond the extractive model that has characterised Chilean development for over a century. Using price and production data for copper (from 1966 to 2024) and lithium (from 1985 to 2024), it shows that both commodities exhibited persistent supply inelasticity, leaving Chile&#
Spatial models, such as the Besag, York and Mollie (BYM)model, have long been used in epidemiology and disease mapping. A commonproblem in these subjects is the modelling of number of disease eventsper region; here the BYM models provides a holistic framework for bothcovariates and dependencies between regions.We use these tools to assess the relative insurance risk associated withthe policyholderSpatial models, such as the Besag, York and Mollie (BYM)model, have long been used in epidemiology and disease mapping. A commonproblem in these subjects is the modelling of number of disease eventsper region; here the BYM models provides a holistic framework for bothcovariates and dependencies between regions.We use these tools to assess the relative insurance risk associated withthe policyholder
It has been suggested that some experiences are transformative; they radically change a person, their understanding of and way of being in the world (cf. Paul 2014). What this means for people who face choices in which they know that they will go through a transformative experience is a complicated matter. How can choice options in such situations be compared and ranked? What could it be to act ra
In this concluding chapter, we focus on outlining the next frontier in research on rhythm cognition and rhythmic communication (RCC), synthesising conceptual, methodological, comparative, and applied directions, as they emerge from the contributions to the Nature Beats volume. While consensus has grown regarding the composite nature of rhythmic competence and the need for integrated quantitative a
Bird flight conversion efficiency (η) determines the amount of metabolic power (Pmet) transformed into mechanical power (Pmech) to remain aloft, and it is central to understanding animal flight energetics, yet it remains difficult to quantify. Using 13C-labelled sodium bicarbonate (NaBi) and particle image velocimetry (PIV), we measured Pmet and Pmech, respectively, in un-instrumented barn swallow
Photochemical regeneration of NADH is essential for bioinspired redox catalysis but remains limited by inefficient electron-proton coordination. We report a donor–acceptor conjugated polymer system with rhodium centers, where electron-donating substituents (–OH, –OMe, –Me) can modulate both photo-induced charge behavior and surface reaction properties. The optimal –OH subsitutents can, on one hand
In response to the limitations of traditional total antioxidant capacity (TAC) determination methods—namely limited sensitivity and weak anti-interference ability—as well as the reliance on toxic hydrogen peroxide in conventional nanozyme-based sensing systems, silver nanoparticles (HA-AgNPs) with enzyme-mimicking catalytic activity were synthesized using hydroxylamine hydrochloride as the reducin
Bacilladnaviridae is a family of viruses with single-stranded, circular DNA genomes that range from 3.4 to 6 kb and contain a short double-stranded region of 0.5–1 kb. The genome is replicated by the rolling-circle mechanism. Bacilladnavirids encode a jelly-roll capsid protein which forms non-enveloped icosahedral capsids with a T=3 symmetry. All cultured bacilladnavirids infect diatoms, a g
This study presents a generic method to selectively enhance radiative pathways over non-radiative states by leveraging vibrational coupling between the host lattice and mid-gap states of doped transition metal ions. While previously demonstrated with Mn, this work successfully incorporates Ni 2+ ions into CsPbCl 3 perovskite nanocrystals (NCs), showcasing the method's versatility and tunability
Doped perovskite lead halide nanocrystals (PHNCs) are promising materials for various optoelectronic applications, but the major challenge faced by the researchers is the inability to dope foreign elements into perovskite lattice because of the strong lead-halide bond energies. In this work, we have used Fe as a dopant in CsPbCl3 to explore different doping techniques based on the colloidal s
