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This paper presents class-D CMOS oscillators capable of an excellent phase noise performance from a very low power supply voltage. Starting from the recognition of the time-variant nature of the class-D LC tank, accurate expressions of the oscillation frequency, oscillation amplitude, current consumption, phase noise, and figure-of-merit (FoM) have been derived. Compared with the commonly used cla
Frequent loss of heterozygosity in head and neck squamous cell carcinoma (HNSCC) has been found in several chromosomal regions such as 3p, 9p, 11q, 13q and 17p. Fragile histidine triad (FHIT) gene is located at 3p14.2 encompassing a common fragile site, and is identified as a tumor suppressor gene. We examined 57 patients with HNSCC using immunohistochemistry, western blot, and reverse transcripta
Haemophilia is a recessively inherited coagulation disorder, in which an X-chromosome mutation causes a deficiency of either coagulation factor VIII (FVIII) in haemophilia A, or factor IX (FIX) in haemophilia B. Intravenous administration of FVIII or FIX can be used to control a bleeding episode, to provide haemostasis during surgery or for long term prophylaxis of bleeding. In special cases, acti
Ultraweak light emission (UWLE) was measured from leaves of various chillingsensitive (Lycopersicon esculentum, Cucumis sativus and Phaseolus vulgaris) and tolerant (Pisum sativum and Vicia faba) plants after exposure to low (47C) temperature in the light. UWLE increased upon chilling treatment combined with illumination with 200 mol m2 s1 PAR in all plants, by about 30 in tolerant and by more tha
Disturbances in glucose metabolism are of importance for violent behaviour in men, but studies in women are lacking. We used the 5h-oral glucose tolerance test (OGTT) in this study of 17 female psychiatric patients, selected for violent behaviour directed against themselves (deliberate self-harm) and 17 healthy controls matched for age and BMI. Following OGTT, patients had higher glucose levels at
L-DOPA remains the gold-standard treatment for Parkinson's disease but causes motor fluctuations and dyskinesia. Metabotropic glutamate receptor type 5 (mGluR5) has been proposed as a target for antidyskinetic therapies. Here, we evaluate the effects of fenobam, a noncompetitive mGluR5 antagonist already tested in humans, using rodent and nonhuman primate models of L-DOPA-induced dyskinesia. In bo
Popular Abstract in Swedish I avhandlingen Det förbjudna mödraskapet argumenterar jag för att surrogatmödraskap bör tillåtas också i Sverige. Idag är metoden förbjuden. Ett av de bärande argumenten är att en legalisering skulle kunna bidra till att bryta ner flera konservativa föreställningar som idag finns kring kvinnors roll i reproduktonen.Surrogate motherhood, or surrogacy, means that a woman carries a child with the explicit intention not to keep the child after the birth. This reproductive method is illegal according to Swedish legislation. The question at heart of the dissertation is the following: Can a legal prohibition of surrogacy be morally justified? My answer is simple no. Consequently, I work with the thesis that there a
Dynamic mode I fracture initiation in impact loaded single edge bend specimens with a quarter notch is investigated by numerical modelling and the results are compared with sets of experimental data from two different steel qualities. The finite element analysis include 2D (two-dimensional) plane strain, 2D plane stress and 3D models. No crack growth is included in the calculations. The impact vel
Two reactors, initially operated at 14 and 23 +/- 1 degrees C (RA and RB, respectively), were inoculated with a bacterial consortium enriched and acclimatized to the respective temperatures over 4 months. The biofilms, formed in the reactors, were studied using scanning electron microscopy, cultivation of the biofilm microflora, and physiological analysis of the isolates. Two bacteria able to mine
Objective-Recent studies failed to show long-term benefit with low-molecular weight heparins (LMWH) in unstable coronary heart disease. A previous study of vascular effects of the cytostatic agent 5-fluorouracil (5-FU) showed that dalteparin prevented thrombosis induced by 5-FU but endothelial damage was not ameliorated and was present also in animals treated with dalteparin only. This study inves
Combined U-Pb, O and Lu-Hf isotope analyses of detrital zircon grains from five major rivers in Ghana are used to investigate the growth and evolution of the Birimian terrane of the West African Craton. The majority of the analysed zircon yields supra-chondritic εHf values, suggesting derivation from primarily juvenile host magmas. Zircon grains from the Birim River in southwestern Ghana deviate f
We report on a theoretical study of the electronic structures of InSb and GaSb nanowires oriented along the [001] and [111] crystallographic directions. The nanowires are described by atomistic, tight-binding models, including spin-orbit interaction. The band structures and the wave functions of the nanowires are calculated by means of a Lanczos iteration algorithm. For the [001]-oriented InSb and
Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age with a peak incidence in adolescents and young adults. The treatment of ES relies on a multidisciplinary approach, coupling risk-adapted intensive neoadjuvant and adjuvant chemotherapies with surgery and/or radiotherapy for control of the primary site and possible metastatic disease. The optimization of ES mul
Objective: The aim of this study was to assess the mortality in hip fracture patients with regard to use of fall-risk-increasing drugs (FRIDs), by comparing survival in exposed and nonexposed individuals. Design: This was a general population-based cohort study. Settings: Data on hip fracture patients were retrieved from three national databases. Participants: All hip fracture patients aged 60 yea
We used the in vitro regenerating frog sciatic nerve to look for effects of insulin and insulin-like growth factors I and II (IGF-I, IGF-II) on regeneration of sensory axons and on injury induced support cell proliferation in the outgrowth region. In nerves cultured for 11 days, a physiological dose (10 ng/ml, ≈ nM) of insulin or IGF-II increased ganglionic protein synthesis (by 20% and 50%, respe
Dolphin sonar has been extensively studied over several decades, and much of its basic characteristics are well known (Au 1993). However, most of these studies have been based on an experimental setup where the dolphin has been trained to be voluntarily fixed, so its directional sonar beam could be recorded with fixed hydrophones. Although this allows for very exact measurements, it most likely ha
In 2009-2014, dose surveys aimed to collect adult patient data and parameters of most common radiographic examinations were performed in six Russian regions. Typical patient doses were estimated for the selected examinations both in entrance surface dose and in effective dose. 75%-percentiles of typical patient effective dose distributions were proposed as preliminary regional diagnostic reference
The localization of glucokinase in pancreatic beta-cell nuclei is a controversial issue. Although previous reports suggest such a localization, the mechanism for its import has so far not been identified. Using immunofluorescence, subcellular fractionation and mass spectrometry, we present evidence in support of glucokinase localization in beta-cell nuclei of human and mouse pancreatic sections, a
