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Although natural products are an important source of drugs and drug leads, identification and validation of their target proteins have proven difficult. Here, we report the development of a systematic strategy for target identification and validation employing drug affinity responsive target stability (DARTS) and mass spectrometry imaging (MSI) without modifying or labeling natural compounds. Thro

The excavation of a low-temperature kiln structure at an affluent Iron Age regional center, Uppåkra, located in southern Sweden, revealed from archeobotanical samples and its context evidence of malting in the process to make beer. Carbonized germinated hulled barley grain (Hordeum vulgare) was recovered from the kiln structure itself and from the surrounding occupationalsurface. Located somewhat The excavation of a low-temperature kiln structure at an affluent Iron Age regional center, Uppåkra, located in southern Sweden, revealed from archeobotanical samples and its context evidence of malting in the process to make beer. Carbonized germinated hulled barley grain (Hordeum vulgare) was recovered from the kiln structure itself and from the surrounding occupationalsurface. Located somewhat

The current use of a 30 million year dateline for accepting genera in the Parmeliaceae is evaluated. Its value is doubtful since evolution obviously went quicker in some lichen groups compared with others. Parallel evolution is also very common among lichens. Polyphyletic genera should always be split, while sister groups may remain split or be combined after considering non-molecular characters.

Introduction: Termination of resuscitation guidelines for out-of-hospital cardiac arrest can identify patients in whom continuing resuscitation has little chance of success. This study examined the outcomes of patients transferred to hospital with ongoing CPR. It assessed outcomes for those who would have met the universal prehospital termination of resuscitation criteria (no shocks administered,

The actor’s practice and bodily training during the twentieth century are specifically related not only to different bodily techniques, but also to language, modern society, and the concept of freedom. Nationalism, anti-intellectualism, bodily and vitalistic purism, and a sceptical distance from the modern project at the beginning of the twentieth century serve as a starting point for a discussion

Neurodegeneration and inflammation are fundamental aspects of many neurological diseases. A genome-wide scan of the response to ventral root avulsion (VRA) in a rat F2 cross discloses specific gene regions that regulate these processes. Two gene loci displayed linkage to neurodegeneration and T cell infiltration, respectively, and a single locus displayed extreme linkage to VRA-induced major histo

The bromide anation of tr-PtCl4BrH2O− has been studied at 25 °C and the chloride anations of tr-PtCl4BrH2O− and PtBr5H2O− at 50 °C. These reactions proceed via halide assisted mechanisms, compatible with the experimental rate laws determined. The bromide anation of tr-PtBr4CIH2O− studied at 50 °C gives PtBr5Cl2− via a bromide assisted path and PtBr62− via an REOA-path. The observed rate law is detThe bromide anation of tr-PtCl4BrH2O− has been studied at 25 °C and the chloride anations of tr-PtCl4BrH2O− and PtBr5H2O− at 50 °C. These reactions proceed via halide assisted mechanisms, compatible with the experimental rate laws determined. The bromide anation of tr-PtBr4CIH2O− studied at 50 °C gives PtBr5Cl2− via a bromide assisted path and PtBr62− via an REOA-path. The observed rate law is det

In the twelfth century the Norbertine order was introduced in parts of Scandinavia. One initiator in the north was Eskil, the powerful archbishop of Lund. However, in the beginning of the thirteenth century the mendicant orders were introduced by successors to the archbishopric. This led to a general decline of other orders. In spite of that the Norbertines managed to prosper in Bäckaskog, an abbeIn the twelfth century the Norbertine order was introduced in parts of Scandinavia. One initiator in the north was Eskil, the powerful archbishop of Lund. However, in the beginning of the thirteenth century the mendicant orders were introduced by successors to the archbishopric. This led to a general decline of other orders. In spite of that the Norbertines managed to prosper in Bäckaskog, an abbe

There is currently interest in low strain HPHT diamond due to its expected application as various types of X-ray optical elements at Synchrotrons, where the X-ray intensity is becoming progressively too severe for the existing materials. The diamond crystals need to be synthesised with unprecedented lattice quality. In recent measurements at the ID19 beamline of European Synchrotron Radiation Faci

Syftet med föreliggande rapport var att beskriva arbetsterapeuts och fysioterapeuts arbete påakutmottagningen, att undersöka hur det nya arbetssättet upplevdes av läkare och sjuksköterskor,samt av tjänstgörande arbetsterapeut och fysioterapeut.Metod: Den på akutmottagningen tjänstgörande arbetsterapeuten och fysioterapeuten antecknadepatienternas ålder, kön och inkomstorsak, samt utförda åtgärder

One of the main issues in context of the severe economical changes on the local media market and the measures the media companies are forced to take is how to maintain high quality of news journalism in the local press. There are concerns that the quality of news will decline and content will be commercialized as McManus (1994) describes it as a market-driven journalism when profit becomes the leaThe local media organisations in Sweden have the last years been involved in initiating new model of business (Melesko 2013). They have mainly been based on economical actions, as cut-downs of editorial staff, integration of different pressrooms and expanded co-operation between papers within same media organisations (Nygren 2013). For instance, editorials and cover of culture news has on several

När de kritiska mönsterdimensionerna för högteknologiska enheter fortsätter krympa och mönstertätheten fortsätter öka, behöver även litografin att gå i samma riktning. En lovande teknologi är sampolymerlitografi, som har en upplösning under 10 nm, en mönsterperiodicitet omkring 7-200 nm, och lätt kan skalas upp till större ytor till en låg kostnad. Användandet av sampolymerer där de ingående blockAs high technology device patterns are continuing to move towards decreasing critical dimensions and increasing pattern density, there is a need for lithography to move in the same direction. Block copolymer (BCP) lithography is a promising technique, which has single digit nanometer resolution, has a pattern periodicity of about 7-200 nm, and easily scales up to large area at a low cost. The use

Objectives: Dysglycemia and glycemic variability are associated with poor outcomes in critically ill patients. Targeted temperature management alters blood glucose homeostasis. We investigated the association between blood glucose concentrations and glycemic variability and the neurologic outcomes of patients randomized to targeted temperature management at 33°C or 36°C after cardiac arrest. Desig

Enligt Arbetsmiljöverkets rapport ”Arbetsmiljön 2013” har 40 procent av alla hotell- och kontorsstädare ont i nacke, rygg, axlar eller armar varje vecka. 60 procent av dem känner sig uttröttade i kroppen. Arbets- och miljömedicin (AMM) Syd har tagit fram åtgärdsnivåer för ett antal belastningsmått, ”AMM Syds åtgärdsnivåer för ergonomisk belastning”, och om man överstiger dessa, anser vi att risken

This paper investigates the usability of a cost model to assess sustainable production. The aim is to develop an established cost model to also take sustainability into consideration and hence evaluate sustainable production on the shop floor. To facilitate the analyse literature have been studied to find indicators for sustainable production. The indicators have then been mappedtogether with para

The clichéd conceptualization of cancer illness as a battle, which the patient can either win or lose, can be problematic. For patients referred to palliative care, it can cause feelings of guilt and failure. This framing of cancer, here referred to as ‘the battle script’, has been questioned in previous research, and there seems to be awareness among health practitioners that battle metaphors sho

In particle accelerator facilities, single-phase niobium is used in superconducting accelerator components. Machining induced surface quality of such components is strongly connected to the functionality of accelerators. In this study, tool wear development and its influence on the surface quality of Nb workpiece have been investigated in longitudinal turning. Uncoated cemented carbide cutting tooIn particle accelerator facilities, single-phase niobium is used in superconducting accelerator components. Machining induced surface quality of such components is strongly connected to the functionality of accelerators. In this study, tool wear development and its influence on the surface quality of Nb workpiece have been investigated in longitudinal turning. Uncoated cemented carbide cutting too