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Trends in type 1 diabetes incidence between 2007 and 2023 and their association with SARS-CoV-2 infection in a population-based matched cohort study among individuals under 30 years old in Sweden

AIMS/HYPOTHESIS: The incidence of type 1 diabetes increased during the pandemic in various countries. SARS-CoV-2 infections may trigger the development of type 1 diabetes, but the evidence is inconclusive. This study aimed to assess trends in type 1 diabetes incidence between 2007 and 2023, and to quantify the association between SARS-CoV-2 infections and the risk for developing type 1 diabetes.ME

Investigating the effect of adding comparisons with prior mammograms to standalone digital breast tomosynthesis screening

Purpose: The purpose is to retrospectively investigate how the addition of prior and concurrent mammograms affects wide-angle digital breast tomosynthesis (DBT) screening false-positive recall rates, malignancy scoring, and recall agreement. Approach: A total of 200 cases were selected from the Malmö Breast Tomosynthesis Screening Trial. They consist of 150 recalled cases [30 true positives (TPs),

Physical child abuse and self-reported health concerns : A case-control study including police-reported cases and unreported controls

BACKGROUND: Child abuse continues to pose a significant threat to children's health. The repercussions of abuse are profound, impacting the child's physical, social, and emotional well-being, with potential long-term effects that may extend into adulthood. To assist in identifying health concerns in children associated with exposure to physical abuse, a health questionnaire was developed to be use

Adjuvant Hyperthermic Intraperitoneal Chemotherapy in Patients With Locally Advanced Colon Cancer (COLOPEC) : 5-Year Results of a Randomized Multicenter Trial

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has

Challenges in population monitoring : Bar-tailed Godwits (Limosa lapponica) on the East Atlantic Flyway defy assumed population structure

Estimating and monitoring migratory bird populations involves significant challenges, even in the most well-studied and easily-counted species, and can be further complicated by long-held but unverified assumptions and by shifting distributions in changing flyway conditions. We illustrate these challenges using Bar-tailed Godwits Limosa lapponica on the East Atlantic Flyway. The subspecies L. l. l

Dynamic multi-layer Aerial system for latent diffusion-based Generative AI Inference at the Edge

In this paper, we investigate a Multi-layer Aerial system for GenAI inference at the Edge (MAGE). Therein, ground user equipments (UEs) request image synthesis services from a remote base station (BS) that leverages the Latent Diffusion Model (LDM) for image generation. Multiple Unmanned Aerial Vehicles (UAVs) are deployed to serve the UEs for relaying their images and prompts to the BS. To reduce

Participation in a digital self-management intervention for osteoarthritis and socioeconomic inequalities in patient-related outcomes

OBJECTIVE: To investigate changes in socioeconomic inequalities in patient-related outcomes and pain medication use, following participation in a digital self-management intervention for osteoarthritis (OA) in Sweden.METHOD: Participants with hip/knee OA enrolled in the digital intervention were included. Self-reported outcomes collected were the numerical rating scale (NRS) pain, activity impairm

Lifestyle and cardiovascular risk factors in a Swedish primary care population with self-reported psychiatric symptoms

Objective: Individuals with psychiatric illness suffer from poorer physical health compared with the general population and have a higher risk of developing cardiovascular and metabolic diseases. This cross-sectional study aims to describe the prevalence of lifestyle and cardiovascular risk factors and the association with self-reported psychiatric symptoms in a population of 40-year-old individua

Ceramides : a potential cardiovascular biomarker in young adult childhood cancer survivors?

Aims The aim of this study was to investigate circulating ceramides involved in cardiovascular disease (CVD) in young adult childhood cancer survivors (CCS) and their correlations to previously reported adverse cardiovascular changes in this cohort. Methods Fifty-seven CCS and 53 healthy controls (age 20-30 years) were studied. Plasma long-chain ceramides, known to be cardi- and results otoxic (C1

Dust source susceptibility in the lower Mesopotamian floodplain of Iraq

The identification of susceptible dust sources (SDSs) based on the analysis of effective factors (i.e. dust drivers) is considered to be one of the primary and cost-effective solutions to deal with this phenomenon. Accordingly, this study aimed to identify SDSs and delineate their drivers using remote sensing data and machine learning (ML) algorithms in a hotspot area in the Lower Mesopotamian flo

Functional properties of starch cultivars of two Andean grains grown in Bolivia: Amaranth (Amaranthus caudatus) and canihua (Chenopodium pallidicaule)

The functional properties of Andean grain starches of two species, amaranth (Amaranthus caudatus) and canihua (Chenopodium pallidicaule), three cultivars each, were studied. The study focused on chemical composition, pasting properties, thermal properties, water solubility index (WSI), swelling power (SP), and granule morphology. All amaranth starches were waxy starches, with amylose content le

The frequency of atrial fibrillatory waves is modulated by the spatiotemporal pattern of acetylcholine release : a 3D computational study

In atrial fibrillation (AF), the ECG P-wave, which represents atrial depolarization, is replaced with chaotic and irregular fibrillation waves (f waves). The f-wave frequency, F f, shows significant variations over time. Cardiorespiratory interactions regulated by the autonomic nervous system have been suggested to play a role in such variations. We conducted a simulation study to test whether t

Hypertension in Pregnancy Among Immigrant and Swedish Women : A Cohort Study of All Pregnant Women in Sweden

BACKGROUND: Little is known about risks of hypertensive disorders of pregnancy in both first-and second-generation immigrant women in Europe and other Western countries; such knowledge may help elucidate the influence of genetic versus social factors on such risks. We aimed to study both first-and second-generation immigrant women for the presence of all types of hypertension (preexisting hyperten

CVOT Summit Report 2023 : new cardiovascular, kidney, and metabolic outcomes

The 9th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November 30-December 1, 2023. This reference congress served as a platform for in-depth discussions and exchange on recently completed outcomes trials including dapagliflozin (DAPA-MI), semaglutide (SELECT and STEP-HFpEF) and bempedoic acid (CLEAR Outcomes), and the

A Population-Based Study on the Incidence, Risk Factors, and Outcome of Salmonella Bloodstream Infections in South Sweden 2012–2022

IntroductionInvasive infections caused by Salmonella are a significant global health concern. This population-based study aimed to comprehensively analyze invasive Salmonella infections in South Sweden, focusing on incidence, clinical presentation, risk factors, and outcomes.MethodsThis population-based observational cohort study, conducted from 2012 to 2022, included all patients with Salmonella

Myocardial infarction in second-generation immigrants compared to native-born Swedes in the total population of Sweden

Background and aims: Environmental and genetic factors predispose to cardiovascular disease. Some first-generation immigrants have a higher cardiovascular risk in Sweden, while less is known about second-generation immigrants. We aimed to analyze the risk of acute myocardial infarction (AMI) among second-generation immigrants in Sweden. Methods: We included all individuals 18 years of age and olde

Feasibility of an evidence-based educational intervention in screening immigrant mothers for postpartum depression : A pretest-posttest experimental design

BACKGROUND: Screening immigrant mothers for postpartum depression has been shown to be challenging for health care professionals in handling cultural implications of postpartum depression, communicating through interpreter and applying translated versions of the screening scale.AIM: The aim of the study was to test the feasibility of an evidence-based educational intervention for Child Health Serv

Levodopa–entacapone–carbidopa intestinal gel : Data from the Swedish national registry for Parkinson's disease

Background: Levodopa–entacapone–carbidopa intestinal gel (LECIG) was introduced on the Swedish market in 2019. The therapy is aimed at patients with Parkinson's disease (PD) with fluctuations and dyskinesias. Long-term efficacy and safety data are lacking. Objective: To investigate the efficacy, tolerability, and safety of LECIG in regular clinical practice for Parkinson's disease in Sweden. Metho

Association Between Physiological Significance and Vulnerable Plaque Characteristics in Patients With Myocardial Infarction : A Prospect II Substudy

Background: Hemodynamically obstructive coronary plaques may contain more vulnerable plaque characteristics than nonobstructive lesions. Objectives: The authors aimed to assess whether pressure-wire–based physiologic indices in nonculprit lesions are associated with vulnerable plaque characteristics. Methods: In the PROSPECT II study, patients with recent myocardial infarction underwent coronary a

Partly decoupled tree-ring width and leaf phenology response to 20th century temperature change in Sweden

The recent warming trend, and associated shifts in growing season length, challenge the principle of uniformitarianism, i.e., that current relations are persistent over time, and complicates the uncritical inferences of past climate from tree-ring data. Here we conduct a comparison between tree-ring width chronologies of Pinus sylvestris L. (Scots pine), Picea abies (L.) Karst. (Norway spruce) and