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Background: Despite considerable interest in the consequences of benzodiazepine and benzodiazepine-related Z-drug (BZDR) use, little is known about whether and how initiation of BZDR treatment relates to the development of alcohol- and drug-related problems. Aims: This study aimed to examine the association of incident BZDR dispensing with subsequent alcohol- and drug-related problems. Methods: Th

Streaming applications are often described using dataflow actor models with a fixed network structure, allowing for static analysis and efficient hardware implementation. However, this fixed structure hinders scalability and design space exploration. This article investigates a representative dataflow toolchain, the StreamBlock compiler for the CAL actor language, along with its Actor Machine (AM)

Prostate cancer is a highly heterogeneous disease, understanding the crosstalk between complex genomic and epigenomic alterations will aid in developing targeted therapeutics. We demonstrate that, even though snail family transcriptional repressor 2 (SNAI2) is frequently amplified in prostate cancer, it is epigenetically silenced in this disease, with dynamic changes in SNAI2 levels showing distin

In Sweden, one of SÄPO’s tasks is counterespionage. Once a suspect has been arrested for a crime in chapter 19 of the Criminal Code, crimes against Sweden security, they are the ones conducting the interrogations. These interrogations may be the difference between a guilty spy walking free or not. It’s also a situation where information of the extent of damages to national security as well as clue

Purpose: To describe a novel technique for optimal orientation and accurate deployment of aortic endografts during complex endovascular aortic repair (cEVAR). Technique: After establishing the femoral access in the standard fashion, a long large-bore dilator is inserted before the cEVAR delivery system. The dilator is advanced beyond the renovisceral segment noticing the degree of axial rotation.

This work reports on a method for uncertainty estimation in simulated collider-event predictions. The method is based on a Monte Carlo-veto algorithm, and extends previous work on uncertainty estimates in parton showers by including uncertainty estimates for the Lund string-fragmentation model. This method is advantageous from the perspective of simulation costs: a single ensemble of generated eve

Introduction: People living with acromegaly and neuroendocrine tumours (NETs) may be treated with injectable somatostatin receptor ligands (SRLs), administered by either a caregiver or as self-injection via a proprietary or generic device. Injection device attributes that contribute to ease of use and storage, minimise preparation requirements, and reduce injection pain are associated with improve

Wideband code division multiple access (WCDMA) systems are interference-limited. When a WCDMA system operates at nearly full capacity, admitting a new user may affect its stability. Therefore, proper call admission control (CAC) is crucial and should balance between quality of service (QoS) requirements for the new user as well as for the existing users and the required high capacity. In this pape

Collective effects in MAX IV 3 GeV storage ring are strongly enhanced by the combination of low emittance, high current and small effective aperture. Three passive harmonic cavities (HC) are introduced to lengthen the bunches, by which beam stabilization is anticipated via decoupling to high frequency wakes, along with Landau damping. The role of the transverse impedance budget of the MAX IV 3 GeV

We consider the problem of stitching image sequences with cameras undergoing pure rotational motion. We leverage the assumption of a locally constant rotation axis, i.e., neighboring frames have a shared but unknown rotation axis. This assumption holds in many common image capturing scenarios, e.g., panoramic sweeping motions. Using this additional constraint, we develop techniques for three-view

BACKGROUND: National European cancer survival rates vary widely. Prolonged diagnostic intervals are thought to be a key factor in explaining these variations. Primary care practitioners (PCPs) frequently play a crucial role during initial cancer diagnosis; their knowledge could be used to improve the planning of more effective approaches to earlier cancer diagnosis. OBJECTIVES: This study sought t

MicroRNAs are short non-coding RNAs with important functions in the regulation of gene expression in healthy and diseased tissues. To optimally utilize the biological and clinical information that is contained in microRNA expression levels, tools for their accurate and cost-effective quantification are needed. While the standard method, qPCR, allows for quick and cheap microRNA quantification, spe

BACKGROUND: X-ray micro-tomography (μCT) is a powerful non-destructive 3D imaging method applied in many scientific fields. In combination with propagation-based phase-contrast, the method is suitable for samples with low absorption contrast. Phase contrast tomography has become available in the lab with the ongoing development of micro-focused tube sources, but it requires sensitive and high-reso

This paper presents an efficient programmable engine that supports diverse interpolation algorithm in different video coding standards, such as H.264/AVC, and the Chinese national standard, AVS. It is a VLIW(very long instruction word) and SIMD(single instruction multiple data) hybrid architecture which could issue four ALU operations and one memory reference or a branch operation in every clock c