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Liraglutide, a once-daily human GLP-1 analogue, in type 2 diabetes provides similar glycaemic control with reduced body weight compared with glimepiride when added to metformin
Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization.
Effects of atmospheric dispersion on the PSF background level
Atmospheric dispersion represents a relatively overlooked problem in connection with the ultimate quality of ELT images corrected by adaptive optics (AO). The aim of this paper is to evaluate the contribution from atmospheric dispersion to the background level of the point-spread function (PSF). Since proper suppression of this level is important for the prospects for direct exo-planet observation
Amine oxidase amperometric biosensor coupled to liquid chromatography for biogenic amines determination
A selective and sensitive method is presented for biogenic amines (BA) determination. The novelty consists in coupling a highly selective electrochemical biosensor to a weak acid cation-exchange column for online detection of amines. A bienzyme design, based on a recently isolated amine oxidase from grass pea and commercial horseradish peroxidase, was used for the biosensor construction. The enzym
Smoking and Coronary Atherosclerosis : Disproportionate Impact on the Right Coronary Artery
Background: We aimed to study the long-term effect of smoking on coronary atherosclerosis progression at the segmental level. Methods: Angiographic data (1989-2017) on current, former, and nonsmokers were collected from the Swedish Coronary Angiography and Angioplasty Registry. The Western Denmark Heart Registry was used to validate the results. Patients with clinically indicated angiography with
Comparison of predictive tools for management of paediatric mild TBI : a prospective cohort study
Background: Multiple clinical practice guidelines and head computed tomography decision rules exist for emergency department (ED) triage of children with traumatic brain injury (TBI). These vary in structure, aim, target cohort, and outcomes, yet are used clinically in similar populations. We compared important clinical and practical characteristics of all major guidelines in a large, real-world p
Socio-geographical disparities in cardiometabolic multimorbidity in Sweden : an Intersectional Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (I-MAIHDA)
Background: Mapping social and geographical disparities in health outcomes helps to identify vulnerable groups that should be targeted for intervention. This study aims to assess the disparities in cardiometabolic multimorbidity, the presence of at least two cardiometabolic diseases (CMD), including type 2 diabetes, heart disease, and stroke, among middle-aged adults across socio-geographical inte
The Utility of Maternal Blood S100B in Women with Suspected or Established Preeclampsia—A Systematic Review
Purpose: Preeclampsia is a serious pregnancy complication without curative treatment. The central nervous system (CNS) is affected in severe cases of preeclampsia. Until now, no biomarker or other predictive method has been established for predicting severe CNS injury, including the development of eclampsia and/or long-term complications. In this systematic review, we aimed to investigate the asso
Time series of Sentinel-1 and Sentinel-2 imagery for parcel-based crop-type classification using Random Forest algorithm and Google Earth Engine
Precise statistics about crop types and productions can support establishing more efficient decisions in the food security framework. The applicability of remote sensing imagery has been confirmed worldwide in crop-related studies. In this chapter, time series Sentinel-1 and Sentinel-2 images were integrated, along with crop inventory, to generate crop-type maps in Imperial County, CA, USA, within
Response to Habibi et al. on ‘Long-term blood pressure dysregulation after preeclampsia’ : toward integrated vascular profiling
Skin rash and contact allergy in continuous glucose monitor and insulin pump users
Mitigation of groundwater salinity vulnerability through land cultivation scenarios
Groundwater in most parts of the world is an important source of agricultural water supply for food production. Soil salinization, however, threatens groundwater quality and may cause irreparable damage to agricultural land. A key to tackling this threat is to analyze the link between agricultural crop water requirements and groundwater quality. This study aimed to investigate salinity effects on
Evaluating Soil Erosion in Dehradun Using the RUSLE Model : Challenges, Impacts, and Policy Strategies for Effective Soil Conservation
Soil erosion poses a significant environmental challenge in Dehradun due to its complex, steep terrain, heavy rainfall, and rapid urbanization. This study employed a Google Earth Engine-based approach to assess the average soil loss annually using the Revised Universal Soil Loss Equation (RUSLE). The analysis used various factors, including rainfall-runoff erosivity (R), soil erodibility (K), slop
Positive correlation between plasma and cerebrospinal fluid galectin-3 in suicide attempters
Objectives: Both depression and suicidal behaviour have been associated with neuroinflammation. Galectin-3 (Gal-3), a protein involved in microglial activation, has been linked to pro-inflammatory cytokines and the severity of depressive symptoms. The extent to which peripheral levels of Gal-3 reflect neuroinflammation is unknown, as is the relationship between Gal-3 and suicidality. Methods: Bloo
CoxSE : Exploring the potential of self-explaining neural networks with Cox proportional hazards model for survival analysis
The Cox Proportional Hazards (CPH) model has long been the preferred survival model for its explainability. However, to increase its predictive power beyond its linear log-risk, it was extended to utilize deep neural networks, sacrificing its explainability. In this work, we explore the potential of self-explaining neural networks (SENN) for survival analysis. We propose a new locally explainable
Aetiology and impact of bacterial bloodstream infections in mechanically ventilated COVID-19 patients : A prospective Swedish multicenter cohort study
Objectives Critically ill COVID-19 patients admitted to the intensive care unit (ICU) are at an increased risk of acquiring bacterial bloodstream infections (BSI). We aimed to describe patient characteristics, risk factors, and the microbiological spectrum in blood cultures and evaluate the impact of ICU-acquired BSI on outcomes in a Nordic setting. Methods A prospective multicenter cohort study w
Familjebehandlares syn på kvalitet - Kunskap och erfarenhet som skapar kvalitet för klienten
This study aims to explore how family therapists in social services perceive and describe quality in their work with family support, and how their experience and knowledge contribute to the quality of their practical work. The study was conducted through qualitative, semi-structured interviews with family therapists working within social services. The results reveal that professionals define quali
Heterogeneous Fenton reactions : oxidation of adsorbing and non-adsorbing probe molecules via H2O2-promoted reduction of iron oxides
Hydroxyl radicals (HO•), produced through reactions between H2O2 and iron oxides, drive biogeochemical transformations, mediate organism toxicity, and facilitate advanced oxidation processes. The effectiveness of these processes depends on the spatial proximity between HO• generation and target substrates. Consequently, the oxidation mechanisms should be governed by interfacial interactions among
Enhanced remote sensing of water surface elevation through fusion of Sentinel-3 altimeter data and climate variables using machine learning
Accurate and continuous monitoring of inland surface water dynamics is vital for sustainable water resource management, climate impact assessment, and ecological planning. This study introduces a machine learning-based remote sensing-based data-fusion framework that improves Sentinel-3 radar altimeter (SRAL) estimations of water surface elevation (WSE) by integrating ERA5 reanalysis climate varia
