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IntroductionThere is a gap in knowledge regarding development of endometriosis and adenomyosis lesions visible at transvaginal ultrasound. The objectives were to evaluate if women with symptoms suggestive of endometriosis or adenomyosis but normal ultrasound examination develop endometriosis or adenomyosis lesions visible at ultrasound over time and if alterations of symptoms over time are associa

Both plasma tau phosphorylated at threonine-181 (pTau181) and tau PET show potential for detecting Alzheimer’s disease (AD) pathology and predicting clinical progression. In this study, we performed a head-to-head comparison between plasma pTau181 and tau PET along the AD continuum. Methods: We included participants from the Amsterdam Dementia Cohort who underwent 18F-flortaucipir (tau) PET and ha

Background: Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements. Purpose: To clarify factors associated with variations in sex hormone concentrations. Data Sources: Systematic literature searches (to July 2019). Study Selection: Prospective cohort studies of community-dwelling men with total testosterone measured using mass spectrometry.

Background: Hypertension is the leading risk factor for cerebral small vessel disease. We aimed to determine whether antihypertensive drug classes differentially affect microvascular function in people with small vessel disease. Methods: We did a multicentre, open-label, randomised crossover trial with blinded endpoint assessment at five specialist centres in Europe. We included participants aged

The aim of this thesis is to contribute to the understanding of everyday leisure travel for social and recreational trip purposes by describing and problematising car use for such trips. Leisure trips are a significant contributor to greenhouse gas emissions and reductions are needed to mitigate climate change. Technical solutions, such as electric vehicles, contribute but research has demonstrate

There is once again an increased demand for interventions supporting small and medium sized enterprises (SMEs) because of the widely held believe that they provide most of the jobs. In order to answer the question whether pro SME policies are justified on factual grounds the International Labour Organization (ILO) and the German Agency for International Cooperation (GIZ) came out with a new study

This paper explores design students’ proposals for a redesign of the interior of a room of silence at the SUS hospital in Malmö. Reflection and existential meaning-making are discussed in relation to the material culture of design, and more specifically in relation to four different themes found among the students’ proposals: nature as common symbolic framework and salutary force; lighting creatin

Poly(ethylene terephthalate) (PET) is the most common polyester plastic in the packaging industry and a major source of environmental pollution due to its single use. Several enzymes, termed PET hydrolases, have been found to hydrolyze this polymer at different temperatures, with the enzyme from Ideonella sakaiensis (IsPETase) having optimal catalytic activity at 30-35 °C. Crystal structures of Is

Background: A decline in episodic memory is one of the earliest cognitive characteristics of Alzheimer disease and memory tests are heavily featured in cognitive composite endpoints that are used to demonstrate treatment efficacy. Assessments of episodic memory can take many forms including free recall, associate learning, and paragraph or story recall. Plasma biomarkers of Alzheimer disease are n

Both in the social and natural sciences, methodologies have been developed to deal with relatively stable conditions, where findings can be validated based on past experiences. At a time when both social and natural phenomena are rapidly changing, new approaches are urgently needed to produce knowledge for systemic change, inform high-stakes decisions, and enable sustainability transitions in the

EU countries have committed to taking national measures to reduce the average energy use of residential buildings by 16% by 2030 and 20–22% by 2035. Each country has decided how to achieve this and which buildings to focus on. However, certain categories of residential buildings, including historical buildings but also second homes, may be exempt from these obligations. In Sweden, second homes con

Context. The Gaia-Sausage-Enceladus merger was a major event in the history of the Milky Way. Debris from this merger has been extensively studied with full kinematic data from the Gaia mission. Understanding the star formation history of the progenitor galaxy aids in our understanding of the evolution of the Milky Way and galaxy formation in general. Aims. We aimed to constrain the star formation

Deep electrification powered by renewable sources has emerged as a pivotal strategy for achieving ambitious CO2 emission reduction targets. However, the true impact of electrification on decarbonization remains inadequately measured because the whole energy chain has not yet been fully considered. This study combines Societal Exergy Accounting and Logarithmic Mean Divisia decomposition analysis to

BACKGROUND: The widespread use of intramedullary nails (IMNs) compared with sliding hip screws (SHSs) in extracapsular hip fractures (AO/OTA 31-A1, 31-A2, 31-A3) has been questioned because of a higher complication rate, although the outcome might have improved through more recent implant designs and the learning curve. This study aimed to investigate if there is a difference with regard to the cu

Aim: To examine adherence, performance, and safety of self-administered aerobic endurance exercise when exercise intensity was prescribed and self-monitored with the Borg RPE scale in patients with chronic kidney disease (CKD), and the relationship between performed exercise and change in walking distance. Materials and Methods: 97 men and 50 women (age 66 ± 14 years, measured GFR 22 ± 8 mL/min/1.

This article presents the results of survey-based research which explores if licensed aircraft maintenance engineers working in Norway, Sweden, and Portugal experience regulated “just culture” as procedural justice-infused processes when occurrence reporting in European Union (EU) civil aviation. Drawing on Tylerian procedural justice theory, the study finds that, perceived procedural justice is m

This paper focuses on the computation of the joint spectral radius (JSR), when the involved matrices are sparse. We provide a sparse variant of the procedure proposed by Parrilo and Jadbabaie to compute upper bounds of the JSR by means of sum-of-squares (SOS) programming. Our resulting iterative algorithm, called SparseJSR, is based on the term sparsity SOS (TSSOS) framework developed by Wang, Mag

Specific causes of death, survival, and recurrence rates were assessed in a cohort of 60 patients who had undergone surgery for craniopharyngioma between 1951 and 1988. Compared to the general population, the standardized mortality ratio (SMR) was increased [5.55; 95% confidence interval (CI), 3.68-8.22], and it was higher among females (SMR, 11.4) than males (SMR, 4.79). The risk of cardio- and c

Background: Little is known about the relative impact of the preoperative symptoms rest pain and tissue loss, and of the arterial segment revascularized, on amputation rate and mortality in patients with chronic limb-threatening ischemia (CLTI). We wanted to investigate this topic further. Method: This population-based observational cohort study involved 10 419 patients revascularized for CLTI in