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Optical spectroscopy has been used as a supplement to conventional techniques for analyzing and diagnosing cancer in many human organs. Because ocular tumors may be characterized by their different melanin content, we investigated the feasibility of using transscleral visible/near-infrared spectroscopy (Vis/NIRS) to estimate the quantity of melanin in a novel uveal melanoma phantom of ex vivo porc

Context Inpatients with nonvalvular atrial fibrillation, warfarin prevents ischemic stroke, but dose adjustment, coagulation monitoring, and bleeding limit its use. Objective To compare the efficacy of the oral direct thrombin inhibitor ximelagatran with warfarin for prevention of stroke and systemic embolism. Design, Setting, and Participants Double-blind, randomized, multicenter trial (20002001)

PURPOSE: We measured serum levels of human glandular kallikrein 2 (hK2) in patients with prostate cancer treated with radical retropubic prostatectomy for clinically localized prostate cancer to determine whether preoperative hK2 levels discriminate stage pT2a/b from pathological stage T3a or greater cancer. This finding would help to predict preoperatively the organ confined versus non-organ conf

Popular Abstract in Swedish Mellan 0.3 och 2.1 % av alla barn föds med portvins fläckar (PWS). Till skillnad mot vissa andra kärlmissbildningar försvinner inte PWS utan tvärtom blir många mer blåröda och tjockare med åren. Majoriteten av patienterna upplever sig vara negativt psykosocialt påverkade av sitt PWS i jämförelse med jämnåriga. Dessa negativa upplevelser minskar efter behandlingarna.(Se This thesis covers 12 years of experience in treating patients with congenital capillary malformations, so called port wine stains (PWS). The wide variation in treatment response to laser therapy has developed a profound need for the development of objective devises to measure treatment outcome, so that the maximum effectiveness of therapy can be achieved without unnecessary treatments. The purpos

Med en växande kunskap om hur klimatet påverkas av byggbranschen för både företag och konsument växer också kraven på klimatkompensation och förbättrade åtgärder kring klimatavtrycken som görs. Företag utmanas mer av intressenter i samhället i sitt miljö- och klimatarbete vilket ställer högre krav på alla aktörer inom byggsektorn. Sveriges mål att senast 2045 inte bidra till några nettoutsläpp av With a growing knowledge of how the environment is affected by the construction industry for both companies and consumers, the demands for climate compensation and improved measures regarding the climate footprint that is made are also growing. Companies are more challenged in their environmental and climate work, which places higher demands on all actors in the building sector. Sweden's goal

Popular science summary Are drugs only drugs for human being? An experiment to see if some of the anthropogenic pharmaceuticals are toxic contaminants for the aquatic environment. All kinds of pharmaceuticals have been using widely and the amount has been increased significantly during the last few decades. Concerns about the occurrence of pharmaceuticals releasing into different matrixes of th

Sammanfattning Instansordningsprincipen är en förvaltningsrättslig princip som huvudsakligen medför att parterna i ett förvaltningsmål är förhindrade att tillföra nytt processmaterial i högre instanser. Principen är, emellertid, inte uttryckligen lagstadgad i Förvaltningsprocesslagen (1971:291), FPL. Istället är det upp till förvaltningsdomstolarna att tolka de uttalande som finns i förarbetena tiSummary The principle of the court hierachy is a principle within administrative law whose intention is to prevent the parties to add new case material in the higher instances. The principle, however, is not explicitly stated in the Administrative Court Procedure Act (1971: 291), FPL. Instead, the administrative courts are given the task to interpret various statements contained in the legislative

Den 1 januari 2006 infördes nya 3:12-regler. Dessa regler avgör hur mycket en delägare i ett fåmansföretag kan ta ut som kapitalbeskattad utdelning och hur stor tjänstebeskattad lön han är tvungen att ta ut. Eftersom skatten är lägre på kapitalbeskattad inkomst än på tjänstebeskattad lön behövs regler som förhindrar fåmansföretagsägare att ta ut all sin inkomst som kapitalbeskattad utdelning. Risk

Eeg-Olofsson K, Cederholm J, Nilsson PM, Zethelius B, Svensson A-M, Gudbjornsdottir S, Eliasson B (Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg; Department of Public Health and Caring Sciences/Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala; Department of Clinical Sciences, Lund University, University Hospital, Malmo; Departmen

Popular Abstract in Swedish I Sverige betonas idag alltmer det hälsofrämjande arbetet riktat mot barn, ungdomar och deras föräldrar. Olika föräldrastödsaktiviteter erbjuds. Det behövs ökad kunskap om varför vissa aktiviteter fungerar bättre än andra. Det är även viktigt att känna till föräldrarnas motiv för att deltaga och upplevelser av stödaktiviteten. Syftet med denna avhandling var att belysa In today's Swedish society there is increasing emphasis on health-promotive work among children, adolescents, and their parents. Knowledge is needed about why certain activities work better than others. It is important to study the parents' motives and experiences of participating in parental supporting programmes. In child health care, mostly among the nurses, there is a contrast between what th

Climate changes have had marked impacts on the natural systems. However its impact will be significant with the hydrological cycle. It is agreed that climate change have adverse impacts on socio-economic development of all nations. But, it is expected that its impact will hit developing countries the worst. The objective of this thesis is to assess the impact of climate change on Gilgel Abay River

The global methane (CH4) budget is becoming an increasingly important component for managing realistic pathways to mitigate climate change. This relevance, due to a shorter atmospheric lifetime and a stronger warming potential than carbon dioxide, is challenged by the still unexplained changes of atmospheric CH4 over the past decade. Emissions and concentrations of CH4 are continuing to increase,

Background: Dietary risks today constitute the largest proportion of disability-adjusted life years (DALYs) globally and in Sweden. An increasing number of people today consume highly processed foods high in saturated fat, refined sugar and salt and low in dietary fiber, vitamins and minerals. It is important that dietary trends over time are monitored to predict changes in disease risk. Methods:

Background: Out of Hospital Cardiac arrest (OHCA) survivors with ST elevation (STE) with or without shockable rhythms often benefit from coronary angiography (CAG) and, if indicated, percutaneous coronary intervention (PCI). However, the benefits of CAG and PCI in OHCA survivors with nonshockable rhythms (PEA/asystole) and no STE are debated. Methods: Using the International Cardiac Arrest Registr

BACKGROUND: The risk of spinal haematoma in patients receiving epidural catheters is estimated using routine coagulation tests, but guidelines are inconsistent in their recommendations on what to do when results indicate slight hypocoagulation. Postoperative patients are prone to thrombosis, and thromboelastometry has previously shown hypercoagulation in this setting. We aimed to better understand

BACKGROUND: Niemann-Pick disease type C (NP-C) is a rare neurovisceral disease characterised by progressive neurological degeneration, where the rate of neurological disease progression varies depending on age at neurological onset. We report longitudinal data on functional disease progression and safety observations in patients in the international NPC Registry who received continuous treatment w

Background: There are no evidence-based recommendations on the optimal time point to initiate non-vitamin K antagonist oral anticoagulants (NOACs) after acute ischemic stroke in patients with atrial fibrillation. We aimed to investigate the efficacy and safety of early versus delayed initiation of NOAC in these patients. Methods: TIMING (Timing of Oral Anticoagulant Therapy in Acute Ischemic Strok

Popular Abstract in Swedish Tänk dig ett system som kan bestämma hur olika typer av luftpartiklar skadar oss när dom hamnar i våra lungor. Ett system som dessutom kan skapa luftpartiklar för dessa studier vid behov och med väl uppmätta egenskaper. Denna avhandling handlar om just ett sådant system och experiment som är viktiga för att förstå om och hur det fungerar. Systemet kallas i denna avhandlExposure to nano-sized and nanostructured aerosol particles with tailored properties are likely to increase in society. Occupational exposure to various kinds of nanostructured aerosol particles such as soot and metal aggregates already exists. To understand the adverse human health effects of these particles, there is a need for systems that can Generate a stable output of aerosol particles, Char

Previous studies on lymphocytes have suggested that patients with head and neck squamous cell carcinoma (HNSCC) have an increased susceptibility for chromosomal damage induced by bleomycin, a known radiomimetic mutagen. However, it has so far not been possible to study whether this genetic instability is present also in the epithelial component of the upper aerodigestive tract mucosa, the tissue f

Background: Ice hockey players often undergo arthroscopic treatment for femoroacetabular impingement syndrome (FAIS); however, only a few studies have reported postoperative patient-reported outcomes. It has been debated whether player position is related to FAIS. Purpose: To evaluate the change in patient-reported outcome measures (PROMs) in high-level ice hockey players from presurgery to 2 year