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Background Chronic congestive heart failure is a complex condition that leads to dysfunction in the peripheral microcirculation. We have previously shown that vascular reactivity is reduced with increasing age. In this study, we examined a group of very old patients with severe chronic heart failure to test the hypothesis that vascular function is further compromised by a combination of heart fail
Popular Abstract in Swedish SVENSK SAMMANFATTNING (SUMMARY IN SWEDISH) Hematopoes och leukemi Hematopoes är benämningen på den process vari alla blodceller genom hela livet kontinuerligt utvecklas i benmärgen, samt vid bildandet av lymfocyter även i lymfkörtlarna. Varje dygn bildas det ca 1012 nya celler i benmärgen för att ersätta uttjänta blodceller som dör och bryts ned. Ett litet antal stamcelWilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. In adult tissues WT1 expression is restricted to few organs, but various forms of cancers express high WT1 levels, suggesting an oncogenic potential
Popular Abstract in Swedish Inledning I detta avhandlingsarbete studeras Mycoplasma pneumoniae (MP) och influensa virus ur olika perspektiv. Dessa två smittämnen orsakar båda årliga utbrott med luftvägsinfektioner som ibland blir omfattande epidemier. I båda fallen kan symptomen variera från lätta förkylningsbesvär till mycket svåra, ibland livshotande lunginflammationer. Infektion med MycoplasmaDiagnostic tests based on nucleic acid amplification have become available for Mycoplasma pneumoniae (MP) and influenza viruses. Here, an MP PCR test detected 100% of infections during the first three symptomatic weeks, whereas classical serology detected 21% week 1, 56% week 2, and 100% week 3. Positive PCR results were uncommon in healthy individuals. Levels of MP DNA were significantly higher i
Chronic breathlessness at rest or on minimal exertion despite optimal treatment of the underlying chronic cause(s) is termed chronic refractory breathlessness. This is prevalent across the community and is an independent indicator of poor prognosis. This narrative review focuses on the palliation of chronic refractory breathlessness in people predominantly with non-cancer diagnoses. Breathlessness
Studies on fetal lung/brain circulation by means of power Doppler technique have suggested a marked reduction in lung perfusion in high-risk pregnancies as a sign of circulation redistribution. The ratio between lung/brain perfusion might therefore give a new method to predict fetal circulation centralization. Objective: The aim of the present study was to obtain fetal lung and cerebral artery rat
Traditional gold mining, using metallic mercury (Hg-0) to form gold amalgam, followed by burning to remove the Hg-0, is widely used in South America, Africa and Asia. The gold is sold to merchants who burn it again to eliminate remaining Hg-0. In Ecuador, 200 gold miners, 37 gold merchants and 72 referents were studied. The median Hg concentrations in urine (U-Hg) were 3.3 (range 0.23-170), 37 (3.
Combining multiple III-V materials into axial nanowire heterostructures has enabled the fabrication of custom nanowire-based devices useful for a wide range of applications. However, our ability to form axial heterostructures between arbitrary combinations of III-V compounds is impeded by a lack of information on the dynamics of the heterojunction formation process, often resulting in suboptimal h
Background: Liver cirrhosis is characterized by a silent phase until decompensation, which is defined by ascites, bleeding from esophageal varices or hepatic encephalopathy. Aim: We compare the clinical course, patterns of survival and causes of death by etiology during long-term follow-up in a large population-based cohort of patients with incident cirrhosis. Material and methods: We used populat
The recent decades have been characterised by a trend where the public sector's been inspired by several methods and strategies from the private sector. The public library is in this case no exception. In this context there are different perspectives on whether or not this will lead to a dramatic change of the role and values of the traditional public library. The aim of this master's thes
Skådespelaryrket kräver mycket av en människa både intellektuellt, färdighetsmässigt och fysiskt. Det förväntas också ofta av en skådespelare att vara musikalisk. Musikalitet kan yttra sig på olika sätt. I skådespelarsammanhang vill jag påstå att musikalitet kan finnas i allt från texthantering till hur man rör sin kropp. Jag är rytmikpedagog, men har också arbetat som skådespelare. Syftet med det
OBJECTIVES: Increased vulnerability to stress has been suggested as a possible mechanism behind medically unexplained conditions such as sensitivity to electricity and common smells. This study examined whether subjective environmental annoyance among the general population is associated with increased physiological reactivity or subjective stress scores.METHODS: Four groups were studied (N=141):
Abstract: Bladder cancer is a heterogenous disease, ranging from minimally invasive, low-grade tumours with lowrecurrence rates and mortality on one end of the spectrum, and muscle invasive, high-grade disease prone torecurrence, progression and death at the other end.The aim of this thesis was to investigate the expression, clinicopathological correlates and prognostic significanceof the candidat
Background: The size of pancreatic ductal adenocarcinoma (PDAC) at diagnosis is an indicator of outcome. Previous studies have focused mostly on patients with resectable disease. The aim of this study was to investigate the relationship between tumour size and risk of metastasis and death in a large PDAC cohort, including all stages. Methods: Patients diagnosed with PDAC between 1988 and 2013 were
Art and Music Schools (kulturskolor) are present in about 97% of Sweden’s municipalities, reaching over 400.000 children and adolescents both in activities outside of and in collaboration with compulsory schools. A national policy has never been established for Art and Music Schools, possibly owing to the fact that they are not considered part of the Swedish education system, but instead stem from
OBJECTIVES: Poor self-rated health is an estimator of quality of life and a predictor of mortality seldom studied in immigrant populations. This work aimed to study self-rated health in relation to social capital, socioeconomic status, lifestyle and comorbidity in immigrants from Iraq - one of the largest non-European immigrant group in Sweden today - and to compare it with the self-rated health o
Introduction: The aim of this study was to evaluate the frequencies of nonsurgical retreatment, root-end surgery, extraction, and further restoration of root-filled teeth in Sweden in 2009 during a follow-up period of 5 years and to compare the outcomes in teeth restored with direct or indirect restorations. Methods: Data from the Swedish Social Insurance Agency were analyzed, and the frequencies
OBJECTIVE: To investigate the impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis by conducting a systematic review of randomized controlled trials (RCTs).METHODS: Literature search up to September 2017 in five major databases with no restriction on publication year or language. Data were extracted
More than 50 irregular satellites revolve around Jupiter and more than 30 around Saturn. There, at least three collisional families were identified. Among these, the Himalia family of prograde irregular moons at Jupiter is characterised by a velocity dispersion of several hundred m/s, inconsistent with a collisional origin (Nesvorný et al., 2003). Here we investigate whether the dispersion could s
The ability to recognize emotions undergoes major developmental changes from infancy to adolescence, peaking in early adulthood, and declining with aging. A life span approach to emotion recognition is lacking in the auditory domain, and it remains unclear how the speaker’s and listener’s ages interact in the context of decoding vocal emotions. Here, we examined age-related differences in vocal em
