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The aim of this thesis was to provide part of the data required in updating/developing computer simulation models (CSMs) for type 2 diabetes mellitus (T2DM) using data obtained from routine clinical practice in Sweden. In paper I, evolution of five biomarkers (i.e., HbA1c, systolic blood pressure, BMI, LDL and total to HDL cholesterol ratio) over time was estimated using data on 5,043 newly diagn
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by tremor, muscle rigidity and bradykinesia, which is primarily due to the degeneration of nigrostriatal dopaminergic neurons. Currently, patients are primarily treated with L-dopa and other drugs that enhance dopaminergic function. Those are effective during the first years, but eventually the majority of patients
This dissertation has three cornerstones: * Haptics * Human-Computer Interaction (HCI) * Blind Users Haptics deals with controlling human movements and getting feedback through the sense of touch. A haptic interface transmits forces to a person’s hand or fingers in a way that mimics the sensation of touching real objects. Virtual haptic touch can be particularly useful for people with visual i
interactIVe introduces safety systems that autonomously brake and steer. The driver is continuously supported by interactIVe assistance systems. They warn the driver in potentially dangerous situations. The systems do not only react to driving situations, but are also able to actively intervene in order to protect occupants and vulnerable road users. The objective of interactIVe is to develop new
SUMMARY Torsten Weimarck: ACADEMY AND ANATOMY. On the History of the Human Body in Art Instruction and Studio Practice from ca. 1600 up to ca. 1810, with Particular Emphasis on the Instruction of Anatomy at the Academies of Art in Stockholm and Copenhagen The aim of the present study is to contribute to the documentation and interpretation of the image and experience of the body by means of two
Popular Abstract in Swedish Denna avhandling gäller glibenklamid som är vårt vanligaste läkemedel för oralt bruk i behandlingen av diabetes mellitus, typ 2 (åldersdiabetes). Glibenklamids upptag, fördelning, omsättning och utsöndring har studerats i detalj hos friska människor samt hos patienter med diabetes. Därtill har läkemedlets och dess metaboliters kinetik relaterats till farmako-dynamiska eGlibenclamide (Gb) is the most commonly employed sulphonylurea worldwide for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). There has been uncertainty concerning its pharmacokinetics (PK) and pharmacodynamics (PD). Numerous long-lasting hypoglycemic reactions, which have sometimes been fatal, have been reported and have been difficult to reconsile with an allegedly short elimina
Architects design work sometimes originates from a simplified view of human demands and needs, which may result in environments that do not fulfill the users requirements. This thesis refers to five different case studies where the affected users were involved in the creation of their dwellings or working environment. The issue of the thesis is that participatory design creates environments which
Selective catalytic reduction of NOx (SCR) has been recognised as an effective post-combustion method for reducing nitrogen oxides from stationary sources. The cost of replacing the catalyst is a major part of the maintenance of the SCR system, hence it is desirable to advance methods to prolong the catalyst life. The objectives of this thesis were to investigate the extent and the mechanism of de
Purpose: The purpose of this study is to develop a model for business process improvement that integrates national culture aspects to achieve sustainable performance improvement. Research questions: * How can national culture aspects be combined into a business process management model? * What is the difference between mapping methods? * How do they relate to each other and their intended scope?
The motivation behind the project was to examine if and how the product attachment value could be prolonged through the form and features of the product. Existing research and literature was used to form an understanding on how we value our belongings, from this four general determinants where clear: pleasure, self-expression, group affiliation and memory. They, together with the study of ordinar
Climate change and anthropogenic influences are significantly altering marine ecosystems in the Baltic Sea, posing substantial challenges for fisheries. The Bornholm Basin, located in the central Baltic Sea, is a crucial fishing area for the region and has been experiencing shifts in fish distribution and abundance due to changing oceanographic conditions. These changes affect not only fish migrat
I pendeltågstrafiken körs ibland tåg med färre vagnar än normalt (så kallade korta tåg). Detta kan påverka hur passagerarna sprider ut sig på plattformen och hur snabbt påstigningen går. Syftet med detta examensarbete är att undersöka effekten av reseinformation om korta tågsammansättningar (tåg med 4 dörrar) på passagerares beteende på plattformen och påstigningstider, med fokus på Lunds centralsIn commuter train traffic, trains sometimes run with fewer carriages than normal (short trains). This can affect how passengers spread out on the platform and how quickly they can board. The purpose of this thesis is to investigate how travel information about short train formations (trains with 4 doors) affects passenger behavior on the platform and boarding times. The study focuses on Lund Centr
Att världen idag kan te sig ganska liten är inget att ta miste på. Det är betydligt lättare och kostar mindre att resa i förhållande till förr, vilket har bidragit till att många av oss i mycket större omfattning reser på semester eller i arbetet, och då stöter på - för oss - främmande och ibland komplicerade problem. Huvudregeln enligt svensk rätt är att bevis skall upptas vid förhandling, enli
Likalöneprincipen innebär rätten till lika lön för kvinnor och män för lika eller likvärdigt arbete. Likalöneprincipen återfinns bl.a. i FNs förklaring om de mänskliga rättigheterna från 1948 och principen har varit en viktig del av EU-rätten sedan Romfördraget. I uppsatsen redogör jag för hur likalöneprincipen har utvecklats inom unionsrätten och i svensk rätt. Fokus ligger på det s.k. marknadsarThe equal pay principle can be found in several international conventions, such as in the United Nations Universal Declaration of Human Rights as well as in The Treaty on the Functioning of the European Union. The main focus of this essay is to look in to the equal pay principle and how it has developed within the European Union as well as in Sweden. The main focus is on the market factor as it is
Extreme events are believed to become frequent, intense and long lasting with climate change. An example of such extreme event is the record breaking summer 2003 heat wave. The 2003 heat wave, accompanied by drought conditions, had severe impacts on the European terrestrial ecosystems. In this study we have used an ecosystem model LPJ-GUESS to investigate how the carbon balance of Europe was affec
Dialectical Behavior Therapy (DBT) has been developed in the USA by Marsha M Linehan, during the last two decades. Linehan elaborated this method for self-destructive women and in continuous cooperation with those women in treatment throughout her research. Randomised controlled studies have showed good results for self-destructive women with a borderline personality disorder. This group of patien
Det här examensarbetet behandlar Suzukipedagogiken och barns upplevelser av föräldrars aktiva stöd och engagemang när deras barn lär sig spela ett musikinstrument. Undervisningsmetoden bygger på interaktionen mellan elev, förälder och lärare, vilket utgör Suzukipedagogikens hörnstenar. För examensarbetets utförande valde jag ut fyra informanter, utifrån kriteriet att de skulle ha haft minst en för
The aim of this Master's thesis is to discuss and analyse co-operation between public and academic libraries. The political changes that were initiated during 2004 have come to alter the conditions for Swedish libraries. The Swedish library law was changed at the 1st of January 2005 and co-operation between libraries is now statuary even if there is no description of how the new mission is to
Tillämpningen av Genèvekonventionen i flyktingmottagande länder har kritiserats av internationell doktrin inom mänskliga rättigheter för att utgå från en manlig norm och ignorera de kränkningar som kvinnor utsätts för då de utspelar sig i den privata sfären. Kvinnors förföljelse har inte samma orsaker och tar inte alltid samma form som mäns, varför de kan ha svårare att få gehör för sina skyddsbehThe determination of refugee status within the scope of the 1951 Geneva Convention on Refugee Status is traditionally carried out within a framework of male experiences. The claims of female asylum-seekers are often based on gender-related persecution and thus will not fit the profile of a convention refugee. As the gendered bias of the historical interpretation of the Geneva Convention is increas
