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Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia

Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion gene landscape in a consecutive series of 195 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP ALL). Using RNA sequencing, we find in-frame fusion genes in 127 (65%) cases, including 27 novel fusions. We describe a subtype characterized by recurrent IGH-DUX4 or ERG-DUX4 fusions, representing 4%

Solvent-Dependent Structural Dynamics in the Ultrafast Photodissociation Reaction of Triiodide Observed with Time-Resolved X-ray Solution Scattering

Resolving the structural dynamics of bond breaking, bond formation, and solvation is required for a deeper understanding of solution-phase chemical reactions. In this work, we investigate the photodissociation of triiodide in four solvents using femtosecond time-resolved X-ray solution scattering following 400 nm photoexcitation. Structural analysis of the scattering data resolves the solvent-depe

Gastroesophageal reflux disease - complications and prognostic aspects

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING Halsbränna och sura uppstötningar är vanliga åkommor i den svenska befolkningen där upp till 20 procent av de tillfrågade uppger sig ha besvär av dessa symtom varje vecka. Både halsbränna och sura uppstötningar anses vara symtom på att magsäcksinnehåll flödar tillbaka upp genom övre magmunnen till matstrupen sk gastroesofageal reflux.This thesis investigates several aspects on gastroesophageal reflux disease (GERD) and associated complications as Barrett’s esophagus and esophageal adenocarcinoma. I. To clarify the natural course of GERD, a pH-metry verified cohort was re-evaluated after 20 years. The course of GERD may well be progressive. A statement based on the evidence that reflux induced complications as esophagitis and

PHENIX central arm tracking detectors

The PHENIX tracking system consists of Drift Chambers (DC), Pad Chambers (PC) and the Time Expansion Chamber (TEC). PC1/DC and PC2/TEC/PC3 form the inner and outer tracking units, respectively. These units link the track segments that transverse the RICH and extend to the EMCal. The DC measures charged particle trajectories in the r-phi direction to determine P-T of the particles and the invariant

Review of particle physics

This biennial Review summarizes much of Particle Physics Using data from previous editions, plus 2205 new measurements from 667 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons We also summarize searches for hypothetical particles such as Higgs bosons, heavy neutrinos, and supersymmetric particles All the particle properties and searc

High levels of (un)switched memory B cells are associated with better outcome in patients with advanced atherosclerotic disease

Background--Atherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount of data from murine atherosclerosis models, evidence of B-cell involvement in human atherosclerotic disease is limited. We therefore investigated the association of circulating B-cell subtypes with the occurrence of secondary cardiovascular events in advan

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Ovaj članak prezentira teoretski i metodološki model za analizu prepričanih iskustava bivših logoraša koji su kao civili odvedeni u koncentracione logore početkom rata u Bosni i Hercegovini 1990-tih godina. Cilj je analizirati prepričane rituale ratnog nasilja u koncentracionim logorima kao i identifikovati kako se počinioci ratnog nasilja i žrtve simbolično definiraju u pričama. Priče o nasilju u

Protocol for outcome reporting and follow-up in the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2)

Aims: The TTM2-trial is a multi-centre randomised clinical trial where targeted temperature management (TTM) at 33 °C will be compared with normothermia and early treatment of fever (≥37.8 °C) after Out-of-Hospital Cardiac Arrest (OHCA). This paper presents the design and rationale of the TTM2-trial follow-up, where information on secondary and exploratory outcomes will be collected. We also prese

GISCOME – Genetics of Ischaemic Stroke Functional Outcome network : A protocol for an international multicentre genetic association study

Introduction: Genome-wide association studies have identified several novel genetic loci associated with stroke risk, but how genetic factors influence stroke outcome is less studied. The Genetics of Ischaemic Stroke Functional outcome network aims at performing genetic studies of stroke outcome. We here describe the study protocol and methods basis of Genetics of Ischaemic Stroke Functional outco

The GALAH survey : A catalogue of carbon-enhanced stars and CEMP candidates

Swan bands-characteristic molecular absorption features of the C2 molecule-are a spectroscopic signature of carbon-enhanced stars. They can also be used to identify carbonenhanced metal-poor (CEMP) stars. The GALAH (GALactic Archaeology with Hermes) is a magnitude-limited survey of stars producing high-resolution, high-signal-to-noise spectra. We used 627 708 GALAH spectra to search for carbon-enh

The centrality of doubting and checking in the network structure of obsessive-compulsive symptom dimensions in youth

Objective. Obsessive-compulsive disorder (OCD) is a heterogeneous condition with well-established symptom dimensions across the lifespan. The objective of the present study was to use network analysis to investigate the internal structure and central features of these dimensions in unselected schoolchildren and in youth with OCD.Method. We estimated the network structure of OCD symptom dimensions

How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? A Study of Paired Core-Needle Biopsies and Surgical Specimens in Early Breast Cancer

In early breast cancer, a preoperative core-needle biopsy (CNB) is vital to confirm the malignancy of suspected lesions and for assessing the expression of treatment predictive and prognostic biomarkers in the tumor to choose the optimal treatments, emphasizing the importance of obtaining reliable results when biomarker status is assessed on a CNB specimen. This study aims to determine the concord

arkstudier – Sida 5 – STUDIEVÄGLEDARBLOGGEN

arkstudier – Sida 5 – STUDIEVÄGLEDARBLOGGEN Hoppa till huvudinnehåll Hem Studievägledaren vid Institutionen för arkeologi och antikens historia i Lund Lära sig vara student Sök Sök Stäng Meny Meny STUDIEVÄGLEDARBLOGGEN Blandad information för studenter på Institutionen för arkeologi och antikens historia vid Lunds universitet arkstudier Sida 5 / 34 16 september, 2024 | arkstudier Are you our futur

https://arkstudier.blogg.lu.se/author/arkstudier/page/5/ - 2026-05-24

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Dreams & Discoveries LTH / FACULTY OF ENGINEERING / LUND UNIVERSITY Content: A place for dreams and disco veries .............. 3 To benefit the climate .................................... 8 To benefit digitalization .............................. 12 To benefit Industry ....................................... 16 To benefit the built environment ............... 20 To benefit life .................

https://www.lth.se/fileadmin/lth/english/Dreams_discoveries.pdf - 2026-05-23

wpss84

wpss84 WORKING PAPERS IN SCANDINAVIAN SYNTAX 84 Maia Andreasson Pronominal object shift – not just a matter of shifting or not 1–20 Gunnar Hrafn Hrafnbjargarsson & Anna-Lena Wiklund General embedded V2: Icelandic A, B, C, etc. 21–52 Gunlög Josefsson “Disagreeing” pronominal reference and gender in Swedish 53–100 David Petersson Embedded V2 does not exist in Swedish 101–149 Henrik Rosenkvist Refere

https://projekt.ht.lu.se/fileadmin/_migrated/content_uploads/WPSS_05.pdf - 2026-05-23

La rhétoriqueTx1011

La rhétoriqueTx1011 La rhétorique des transformations homogènes – ou l’argumentation fondée sur la structure de la réalité Göran Sonesson, Université de Lund Dans la sémiotique visuelle, le renouveau de la rhétorique, initié par le Groupe µ (1992), sans compter quelques initiatives timides et confuses dues a Barthes (1964), Durand, Cohen et d’autres (Bremond 1970), passe par ce que les anciens app

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_ccs/La_rhetoriqueTx.pdf - 2026-05-23

Consumption of vegetables and fruits and risk of breast cancer

Context The intake of vegetables and fruits has been thought to protect against breast cancer. Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption. Objective To examine the relation between total and specific vegetable

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Arbetsgivaralliansen Branschkommitté Utbildning och Folkbildning Lärarförbundet och Lärarnas Riksförbunds Samverkansråd Akademikerförbunden/SULF Fackförbundet ST/Visions Samverkansråd Högskola Bransch- och löneavtal 2019-2022 1 Innehåll Författningar och förkortningar 2 § 1 Avtalets omfattning 3 § 2 Allmänna åligganden 4 § 3 Behörighet och bedömningsgrunder vid anställning 5 § 4 Anställning 7 § 5

https://www.saco.se/globalassets/lokala-akademikerforeningar/privat/akademikerforbunden-aht/dokument/kollektivavtal/arbetsgivaralliansen_hogskola_branschavtal_2019-2022.pdf - 2026-05-24

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Professorsinstallation LUNDS UNIVERSITET | UNIVERSITETSAULAN | 15 OKTOBER 2021 KL 16.00 Denna broschyr kan beställas från sektionen Kommunikation, tel 046-222 70 10, e-post info@kommunikation.lu.se. Broschyren finns även på www.lu.se/om-universitetet/akademiska-hogtider/professorsinstallationer Produktion Sektionen Kommunikation och Media-Tryck, Lunds universitet Foto Kennet Ruona ISBN 978-91-8039

https://www.vetenskaphalsa.se/wp-content/uploads/2021/12/Prof_inst_skrift_15okt_2021.pdf - 2026-05-24

Discovery and engineering of the antibody response to a prominent skin commensal

The ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8+ T cell response pre-emptively, in the absence of an infection1. However, the scope and purpose of this anticommensal immune programme are not well defined, limiting our ability to harness it therapeutically. Here, we show that this colonist also induces a potent, durable and specific antibody response that is conserved in human