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The many faces of diabetes: a disease with increasing heterogeneity

Diabetes is a much more heterogeneous disease than the present subdivision into types 1 and 2 assumes; type 1 and type 2 diabetes probably represent extremes on a range of diabetic disorders. Both type 1 and type 2 diabetes seem to result from a collision between genes and environment. Although genetic predisposition establishes susceptibility, rapid changes in the environment (ie, lifestyle facto

Skin sensitizers differentially regulate signaling pathways in MUTZ-3 cells in relation to their individual potency.

Due to the recent European legislations posing a ban of animal tests for safety assessment within the cosmetic industry, development of in vitro alternatives for assessment of skin sensitization is highly prioritized. To date, proposed in vitro assays are mainly based on single biomarkers, which so far have not been able to classify and stratify chemicals into subgroups, related to risk or potency

The virtue of extraction and decolonial recollection in Gállok, Sápmi

Swedish mining is often envisioned as virtuous, as coinciding harmoniously with quests for sustainability and the cultural survival of indigenous Sami peoples. This chapter posits that Sweden’s sense of exceptionalism in mining is embedded in a colonial/extractive system of knowledge that fails to mention non-capitalist, anticolonial relationalities to nature and ways of life. The normalised statu

On the initial binary population for star cluster simulations

Colour–magnitude diagrams (CMDs) are powerful tools that might be used to infer stellar properties in globular clusters (GCs), for example, the binary fraction and their mass ratio (q) distribution. In the past few years, observations have revealed that q distributions of GC main-sequence binaries are generally flat, and a distribution characterized by a strong increase towards q ≈ 1 is not typica

Bröstsmärta vid covid-19 var troligen virusorsakad myokardit

Vi redogör för ett patientfall med covid-19-associerad myokardit.Patienten hade förhöjda hjärtskademarkörer, men inte avsevärt stegrade inflammationsmarkörer såsom D-dimer och interleukin-6. Tidigare fallrapporter indikerar att en myokarditbild kan uppträda vid covid-19, både genom förekomst av sars-cov-2 i myokardiet och immunologisk aktivering. I detta fall var orsaken sannolikt infektion i myok

Adrenalectomy for incidental and symptomatic phaeochromocytoma : retrospective multicentre study based on the Eurocrine® database

BACKGROUND: Phaeochromocytoma is sometimes not diagnosed before surgery and may present as an adrenal incidentaloma. The aim of this study was to investigate differences in clinical presentation and perioperative outcome in patients with subclinical and symptomatic phaeochromocytoma, and in patients operated with and without preoperative α-blockade. METHODS: This was a retrospective observational

Micronutrient intake and biochemistry in adolescents adherent or nonadherent to supplements 5 years after Roux-en-Y gastric bypass surgery

Background: Roux-en-Y gastric bypass (RYGB) is an effective obesity treatment in adults and has become established in adolescents. Lower adherence to supplementation in adolescents confers a risk for long-term nutritional deficiencies. Objectives: To assess adherence to supplementation, micronutrient intake, and biochemistry in adolescents through 5 years after RYGB. Setting: University hospitals,

Developing chlorine-based antiseptic by electrolysis

The use of Alcohol-based antiseptics is efficient and approved, however it has some limitations. This paper examined the possibility of using hypochlorite water as a chlorine-based antiseptic for handwashing in public buildings and healthcare facilities. The electrolysis method was used, which produces Hypochlorous acid (HOCl) from mixing drinking water with small amounts of sodium hydroxide. Hypo

Pregnancy outcome in women with gestational diabetes – A longitudinal study of changes in demography and treatment modalities

Introduction: Gestational diabetes is on the rise and demographics are changing in many countries due to increased migration. Simultaneously, the treatment of gestational diabetes in our clinic has shifted towards metformin with substantially less insulin treatment. The aim was to study the impact of these changes on metabolic control and pregnancy outcome by comparing women diagnosed with gestati